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Database: UniProt
Entry: A0A249KSM9_9ACTN
LinkDB: A0A249KSM9_9ACTN
Original site: A0A249KSM9_9ACTN 
ID   A0A249KSM9_9ACTN        Unreviewed;       775 AA.
AC   A0A249KSM9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family {ECO:0000313|EMBL:ASY19781.1};
GN   ORFNames=A7sIIA15_02605 {ECO:0000313|EMBL:ASY19781.1};
OS   Candidatus Planktophila vernalis.
OC   Bacteria; Actinomycetota; Actinomycetes; Candidatus Nanopelagicales;
OC   Candidatus Nanopelagicaceae; Candidatus Planktophila.
OX   NCBI_TaxID=1884907 {ECO:0000313|EMBL:ASY19781.1, ECO:0000313|Proteomes:UP000217186};
RN   [1] {ECO:0000313|EMBL:ASY19781.1, ECO:0000313|Proteomes:UP000217186}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MMS-IIA-15 {ECO:0000313|EMBL:ASY19781.1};
RA   Neuenschwander S.M., Salcher M., Ghai R., Pernthaler J.;
RT   "High microdiversification within the ubiquitous acI lineage of
RT   Actinobacteria.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential cell division protein that coordinates cell
CC       division and chromosome segregation. The N-terminus is involved in
CC       assembly of the cell-division machinery. The C-terminus functions as a
CC       DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC       recombination site, which is located within the replication terminus
CC       region. Required for activation of the Xer recombinase, allowing
CC       activation of chromosome unlinking by recombination.
CC       {ECO:0000256|ARBA:ARBA00024986}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC       {ECO:0000256|ARBA:ARBA00006474}.
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DR   EMBL; CP016776; ASY19781.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A249KSM9; -.
DR   KEGG; pvn:A7sIIA15_02605; -.
DR   Proteomes; UP000217186; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR   Gene3D; 3.30.980.40; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR025199; FtsK_4TM.
DR   InterPro; IPR041027; FtsK_alpha.
DR   InterPro; IPR002543; FtsK_dom.
DR   InterPro; IPR018541; Ftsk_gamma.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR   PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR   Pfam; PF13491; FtsK_4TM; 1.
DR   Pfam; PF17854; FtsK_alpha; 1.
DR   Pfam; PF09397; FtsK_gamma; 1.
DR   Pfam; PF01580; FtsK_SpoIIIE; 1.
DR   SMART; SM00843; Ftsk_gamma; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50901; FTSK; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00289}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000217186};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        57..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        87..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        121..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        176..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          425..625
FT                   /note="FtsK"
FT                   /evidence="ECO:0000259|PROSITE:PS50901"
FT   BINDING         442..449
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ   SEQUENCE   775 AA;  83868 MW;  C2BA78E5E229BF4C CRC64;
     MRSVAKKKSK SKSGAVGGAL GRGLTAIWRF IAKILGNSVR FIARGARDLD PAHQRDGIAF
     LILILALVAT AGTWFHADNI VGRAVYAFVY GGFGRIGFIT PLVLIYFAFK LFRTPEDKAA
     IGRVVVGTLT LLLSSTGISH LLNGSTGTGA TAMREGGGWI GYAVTTPLVS LMTSVLTYPV
     LIIVFIFGLL VVTATPVSQV LDRFTSSASW LWAKRPERPI KVEDFEITDT PPFESPIVAA
     WNEPVEEDEE ELDEESFDEE FTVPIPISPV ITPETVTKRP EQLLLTPDST YELPPADLLR
     TGPAAKAKSK VNDLVVAALT EVFAQFEIDA QVTGFMRGPT VTRYEVELGN AVKVERITAL
     AKNISYAVAS SDVRILSPIP GKSAVGIEIP NTDREIVALG DVLRSSVAGQ DHHPMLVALG
     KDVEGNFVCA NLAKMPHLLV AGATGAGKSS MINAMITSIL VRATPDEVRL VLIDPKRVEL
     TAYEGIPHLI TPIITNPKKA SDALTWVVRE MDLRYEDLST FGFRHIDDFN KAVRAGKVIV
     PPGSDRTVEP YPYLLVIIDE LADLMIVAAK EVEESVVRIT QLARSAGIHL VLATQRPSVD
     VVTGLIKANV PSRLSFATSS LADSRVILDS PGAEKLVGQG DALFIPMGAS RAVRIQGAYV
     SEREIEAVTT HVKKQLKPRY RDDVTAVQSH PKMVDKEIGD DLDILLQAVE LVVGTQFGST
     SMLQRKLRVG FAKAGRLMDL MESRGIVGPS EGSKARTVLV KPDELDSVIA TLRDY
//
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