ID A0A249KSM9_9ACTN Unreviewed; 775 AA.
AC A0A249KSM9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family {ECO:0000313|EMBL:ASY19781.1};
GN ORFNames=A7sIIA15_02605 {ECO:0000313|EMBL:ASY19781.1};
OS Candidatus Planktophila vernalis.
OC Bacteria; Actinomycetota; Actinomycetes; Candidatus Nanopelagicales;
OC Candidatus Nanopelagicaceae; Candidatus Planktophila.
OX NCBI_TaxID=1884907 {ECO:0000313|EMBL:ASY19781.1, ECO:0000313|Proteomes:UP000217186};
RN [1] {ECO:0000313|EMBL:ASY19781.1, ECO:0000313|Proteomes:UP000217186}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMS-IIA-15 {ECO:0000313|EMBL:ASY19781.1};
RA Neuenschwander S.M., Salcher M., Ghai R., Pernthaler J.;
RT "High microdiversification within the ubiquitous acI lineage of
RT Actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Required for activation of the Xer recombinase, allowing
CC activation of chromosome unlinking by recombination.
CC {ECO:0000256|ARBA:ARBA00024986}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP016776; ASY19781.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A249KSM9; -.
DR KEGG; pvn:A7sIIA15_02605; -.
DR Proteomes; UP000217186; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000217186};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 57..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 425..625
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT BINDING 442..449
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 775 AA; 83868 MW; C2BA78E5E229BF4C CRC64;
MRSVAKKKSK SKSGAVGGAL GRGLTAIWRF IAKILGNSVR FIARGARDLD PAHQRDGIAF
LILILALVAT AGTWFHADNI VGRAVYAFVY GGFGRIGFIT PLVLIYFAFK LFRTPEDKAA
IGRVVVGTLT LLLSSTGISH LLNGSTGTGA TAMREGGGWI GYAVTTPLVS LMTSVLTYPV
LIIVFIFGLL VVTATPVSQV LDRFTSSASW LWAKRPERPI KVEDFEITDT PPFESPIVAA
WNEPVEEDEE ELDEESFDEE FTVPIPISPV ITPETVTKRP EQLLLTPDST YELPPADLLR
TGPAAKAKSK VNDLVVAALT EVFAQFEIDA QVTGFMRGPT VTRYEVELGN AVKVERITAL
AKNISYAVAS SDVRILSPIP GKSAVGIEIP NTDREIVALG DVLRSSVAGQ DHHPMLVALG
KDVEGNFVCA NLAKMPHLLV AGATGAGKSS MINAMITSIL VRATPDEVRL VLIDPKRVEL
TAYEGIPHLI TPIITNPKKA SDALTWVVRE MDLRYEDLST FGFRHIDDFN KAVRAGKVIV
PPGSDRTVEP YPYLLVIIDE LADLMIVAAK EVEESVVRIT QLARSAGIHL VLATQRPSVD
VVTGLIKANV PSRLSFATSS LADSRVILDS PGAEKLVGQG DALFIPMGAS RAVRIQGAYV
SEREIEAVTT HVKKQLKPRY RDDVTAVQSH PKMVDKEIGD DLDILLQAVE LVVGTQFGST
SMLQRKLRVG FAKAGRLMDL MESRGIVGPS EGSKARTVLV KPDELDSVIA TLRDY
//