ID A0A249KSQ8_9ACTN Unreviewed; 735 AA.
AC A0A249KSQ8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Competence protein ComEC {ECO:0000313|EMBL:ASY19729.1};
GN ORFNames=A7sIIA15_02335 {ECO:0000313|EMBL:ASY19729.1};
OS Candidatus Planktophila vernalis.
OC Bacteria; Actinomycetota; Actinomycetes; Candidatus Nanopelagicales;
OC Candidatus Nanopelagicaceae; Planktophila.
OX NCBI_TaxID=1884907 {ECO:0000313|EMBL:ASY19729.1, ECO:0000313|Proteomes:UP000217186};
RN [1] {ECO:0000313|EMBL:ASY19729.1, ECO:0000313|Proteomes:UP000217186}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMS-IIA-15 {ECO:0000313|EMBL:ASY19729.1};
RA Neuenschwander S.M., Salcher M., Ghai R., Pernthaler J.;
RT "High microdiversification within the ubiquitous acI lineage of
RT Actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP016776; ASY19729.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A249KSQ8; -.
DR KEGG; pvn:A7sIIA15_02335; -.
DR OrthoDB; 7177610at2; -.
DR Proteomes; UP000217186; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000217186};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 208..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..135
FT /note="DUF4131"
FT /evidence="ECO:0000259|Pfam:PF13567"
FT DOMAIN 187..445
FT /note="ComEC/Rec2-related protein"
FT /evidence="ECO:0000259|Pfam:PF03772"
FT DOMAIN 483..566
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF00753"
SQ SEQUENCE 735 AA; 78310 MW; 92CC8FADA061AA18 CRC64;
MWAGALFQSA CAPWQISCAA LALGALSLLS RKARFSVIIC ALLLGSTVMS IRQASLANSQ
ITRFFMQSAT LTAEVVTDPS KTSTGKYSFI ARAILVNNSS IHYKLRVPIR VMTSHRSVTK
LLPGQRFSAQ GRIVSSKEAR VAALVVIKDD IHILTPPSRW ASALGAIRLG LRSLSGDGNA
GALIPGMVLG DTSKQSAQFK DSMKRSGLTH LVAVSGANFA LVSAFVLWLM QFLFSKMKFR
LSATAISLIA FIALVRPSPS VLRAAAMAAV LLIAQGTKRG RDSLPALGFA MAAVVIVDPW
QARDAGFALS VLATAGLLLF APVLIEKLSS HMPVKLAQAL SPPIAATVFC SPIIVALSGY
LAPMSIIANL LAAPFVAPIT IVGFIAALFS PFASFISSVL IWFIRFPAGA IALIAQWASS
FPVLTLQTGK IGFLIVASFT LLAWLFKKWF KYIVIFTLII LISITWLQRW PGGDWQVANC
DIGQGDSMVI NLGNHQGIVI DVGPDPVAED RCLKALGIKE IPLLILSHFH ADHVAGLPGA
LNKRTVGQVW VSVNSAPLVE SAMAGSALAG VEMIKAVRGM GARVGALSIN VLWPTLSATS
FEEMPGDGSQ INNSSIATLI TSDAFSIFAG GDIEPPVQEI LVKDVGPVDI YKVSHHGSRY
QDVAFMSALH PRISIISVGA GNTYGHPAVQ TLEALARLGS EVLRTDINGA IAVQVRNHQF
TVRKAKGRFN LIRWG
//
