ID A0A249KTI9_9ACTN Unreviewed; 1075 AA.
AC A0A249KTI9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=A7sIIA15_04295 {ECO:0000313|EMBL:ASY20086.1};
OS Candidatus Planktophila vernalis.
OC Bacteria; Actinomycetota; Actinomycetes; Candidatus Nanopelagicales;
OC Candidatus Nanopelagicaceae; Candidatus Planktophila.
OX NCBI_TaxID=1884907 {ECO:0000313|EMBL:ASY20086.1, ECO:0000313|Proteomes:UP000217186};
RN [1] {ECO:0000313|EMBL:ASY20086.1, ECO:0000313|Proteomes:UP000217186}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMS-IIA-15 {ECO:0000313|EMBL:ASY20086.1};
RA Neuenschwander S.M., Salcher M., Ghai R., Pernthaler J.;
RT "High microdiversification within the ubiquitous acI lineage of
RT Actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; CP016776; ASY20086.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A249KTI9; -.
DR KEGG; pvn:A7sIIA15_04295; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000217186; Chromosome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07431; PHP_PolIIIA; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000217186};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..71
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1075 AA; 117317 MW; 23C0F899F4B968EB CRC64;
MSFIHLNVAS AYSLKYGTTQ PADLVERAAA FEMPALALTD RDGLAGAIRF AQSCVDFGIA
PIIGVNLAVD MGGSNNRLTL LAHSDGGWRS LCRLLTSLAM TSDSRNPVLT LDFLQRFSHY
STNVYALHGP HSLVGSLITD NRIDAAFTAF NQTRDLFADN AIECVSHLVA GKGPRSTSHA
AKSLIFARDH DIDALITNAV RMRDRADGPV ADVLDCARQL VPLHPRHIER QNAEGFLKSS
DEMILLAGEI ARAAGERTPR QLLATTRAWA ERSLLSPQRD IGLGGAHLPE AHVVGADSAH
EMRVLLRTRS EAAINWRYSD SAMIKKARTR LDDELSTVAT LGFESYFLTV ADICDMARGA
GVRVAARGSG AGSLICHLLG ISGVDPLQHG LLMERFCSPL RRALPDIDID VESHRRLEIY
DMVFKRYGNT DWDVPGNQSR CATVAMVDTY RARHAIRDAG AALGLPGMEI DMLAKSMPHV
RARNISKTLE NLPELRSLNI SAPLTAMTIA LAERLDGLPR HLSMHPCAIV LSDGGLLDRT
PLLSNASGYP MVVFDKDDVE AIGLLKLDVL GVRMQSAISY ALTEIERTEN LNVDIDAVPL
DDADTYALIQ STNTLGLFQI ESPGQRELVG KLEPKTFTDL IIDISLFRPG PVKSDMITPF
LKARHGWAKA QIIHPDLYEI LRDTEGVVVF HEQVIEIIAT MTGVSLASAD EKRRALGDRD
GQQEVCDWFF PAATAKGYEL PIVHEIWEVL RAFASFGFCK AHAAAFALPT YQSAWLKTHY
PAAFLAGVLT HDPGMYPRRL IVDEVRQMGL KVAPLDINES DSVYRVEENG SAVRIALSTI
TKISDGEVAS IIAGRPYIDL TDFVRRSGCS APVTESAILT GAFDRLHSDV NRRDLLLHFS
DLQKSPNAGV TGAQMNLAFA PPVLISSGLP DMSPAEIVQH EIARLGIDMS EHLVSFYSDF
LNSIGAVRSC DLLAQRSRSS VLVAGIKVAM QTPPVRSGKR VIFVSLDDGY GCSDSTFFSD
AQTDFASTLY SSSLLLIRGI TRRTGARGIS LRATGAWDLR AAYESWRTKE STLAI
//