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Database: UniProt
Entry: A0A249KTI9_9ACTN
LinkDB: A0A249KTI9_9ACTN
Original site: A0A249KTI9_9ACTN 
ID   A0A249KTI9_9ACTN        Unreviewed;      1075 AA.
AC   A0A249KTI9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=A7sIIA15_04295 {ECO:0000313|EMBL:ASY20086.1};
OS   Candidatus Planktophila vernalis.
OC   Bacteria; Actinomycetota; Actinomycetes; Candidatus Nanopelagicales;
OC   Candidatus Nanopelagicaceae; Candidatus Planktophila.
OX   NCBI_TaxID=1884907 {ECO:0000313|EMBL:ASY20086.1, ECO:0000313|Proteomes:UP000217186};
RN   [1] {ECO:0000313|EMBL:ASY20086.1, ECO:0000313|Proteomes:UP000217186}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MMS-IIA-15 {ECO:0000313|EMBL:ASY20086.1};
RA   Neuenschwander S.M., Salcher M., Ghai R., Pernthaler J.;
RT   "High microdiversification within the ubiquitous acI lineage of
RT   Actinobacteria.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR   EMBL; CP016776; ASY20086.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A249KTI9; -.
DR   KEGG; pvn:A7sIIA15_04295; -.
DR   OrthoDB; 9803237at2; -.
DR   Proteomes; UP000217186; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   CDD; cd07431; PHP_PolIIIA; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000217186};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          4..71
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
SQ   SEQUENCE   1075 AA;  117317 MW;  23C0F899F4B968EB CRC64;
     MSFIHLNVAS AYSLKYGTTQ PADLVERAAA FEMPALALTD RDGLAGAIRF AQSCVDFGIA
     PIIGVNLAVD MGGSNNRLTL LAHSDGGWRS LCRLLTSLAM TSDSRNPVLT LDFLQRFSHY
     STNVYALHGP HSLVGSLITD NRIDAAFTAF NQTRDLFADN AIECVSHLVA GKGPRSTSHA
     AKSLIFARDH DIDALITNAV RMRDRADGPV ADVLDCARQL VPLHPRHIER QNAEGFLKSS
     DEMILLAGEI ARAAGERTPR QLLATTRAWA ERSLLSPQRD IGLGGAHLPE AHVVGADSAH
     EMRVLLRTRS EAAINWRYSD SAMIKKARTR LDDELSTVAT LGFESYFLTV ADICDMARGA
     GVRVAARGSG AGSLICHLLG ISGVDPLQHG LLMERFCSPL RRALPDIDID VESHRRLEIY
     DMVFKRYGNT DWDVPGNQSR CATVAMVDTY RARHAIRDAG AALGLPGMEI DMLAKSMPHV
     RARNISKTLE NLPELRSLNI SAPLTAMTIA LAERLDGLPR HLSMHPCAIV LSDGGLLDRT
     PLLSNASGYP MVVFDKDDVE AIGLLKLDVL GVRMQSAISY ALTEIERTEN LNVDIDAVPL
     DDADTYALIQ STNTLGLFQI ESPGQRELVG KLEPKTFTDL IIDISLFRPG PVKSDMITPF
     LKARHGWAKA QIIHPDLYEI LRDTEGVVVF HEQVIEIIAT MTGVSLASAD EKRRALGDRD
     GQQEVCDWFF PAATAKGYEL PIVHEIWEVL RAFASFGFCK AHAAAFALPT YQSAWLKTHY
     PAAFLAGVLT HDPGMYPRRL IVDEVRQMGL KVAPLDINES DSVYRVEENG SAVRIALSTI
     TKISDGEVAS IIAGRPYIDL TDFVRRSGCS APVTESAILT GAFDRLHSDV NRRDLLLHFS
     DLQKSPNAGV TGAQMNLAFA PPVLISSGLP DMSPAEIVQH EIARLGIDMS EHLVSFYSDF
     LNSIGAVRSC DLLAQRSRSS VLVAGIKVAM QTPPVRSGKR VIFVSLDDGY GCSDSTFFSD
     AQTDFASTLY SSSLLLIRGI TRRTGARGIS LRATGAWDLR AAYESWRTKE STLAI
//
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