ID A0A249LI30_9ACTN Unreviewed; 426 AA.
AC A0A249LI30;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Hemolysin or related protein {ECO:0000313|EMBL:ASY28800.1};
GN ORFNames=A1sIIB60_02140 {ECO:0000313|EMBL:ASY28800.1};
OS Candidatus Planktophila lacus.
OC Bacteria; Actinomycetota; Actinomycetes; Candidatus Nanopelagicales;
OC Candidatus Nanopelagicaceae; Planktophila.
OX NCBI_TaxID=1884913 {ECO:0000313|EMBL:ASY28800.1, ECO:0000313|Proteomes:UP000217167};
RN [1] {ECO:0000313|EMBL:ASY28800.1, ECO:0000313|Proteomes:UP000217167}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMS-IIB-60 {ECO:0000313|EMBL:ASY28800.1};
RA Neuenschwander S.M., Salcher M., Ghai R., Pernthaler J.;
RT "High microdiversification within the ubiquitous acI lineage of
RT Actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP016783; ASY28800.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A249LI30; -.
DR Proteomes; UP000217167; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR PANTHER; PTHR22777; HEMOLYSIN-RELATED; 1.
DR PANTHER; PTHR22777:SF17; UPF0053 INNER MEMBRANE PROTEIN YFJD; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01595; CNNM; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR SMART; SM00116; CBS; 2.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 6..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..182
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 201..261
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 269..326
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 426 AA; 47027 MW; 04BA79FCB98DBF3B CRC64;
MNAVNISAIV ALIAFAGFLA ASESALTSIS RILIEELESK RGGHLLKKYS QHPSRYLNVL
LLVRKICEFS AAALLAVALL REYSSAQAMI ATVVIMVVLS YVVVGVGPRT LGRQQPHKWA
RAGISVAYFL AFILGPVTNL LIAIGNAITP GKGFRGGPFT NEAELRDLVD QAHERGLVES
DEHEMIHSVF ELGDTLVREL MVHRTDMVWI EGDKTLRQAL SLALRSGYSR VPVVGENLDK
IIGIAYVKDL AKRALDHHEA ETTEKVEQHM RPAVFVPEIK IAAELLKEMQ RDQIHLAIVV
DEYGGTAGII TIEDIIEEIV GEITDEFDDG DEAFTWINED KARAKATLHI EDLADELKIE
IDKEDFEDVD TIGGLMAQKL GRVPIAGSTI SMLGWSITSE RPVGRRRKIS SVIIERVKNG
EVDEHE
//
