ID A0A249LL77_9ACTN Unreviewed; 759 AA.
AC A0A249LL77;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family {ECO:0000313|EMBL:ASY29757.1};
GN ORFNames=A1sIIB60_04445 {ECO:0000313|EMBL:ASY29757.1};
OS Candidatus Planktophila lacus.
OC Bacteria; Actinomycetota; Actinomycetes; Candidatus Nanopelagicales;
OC Candidatus Nanopelagicaceae; Planktophila.
OX NCBI_TaxID=1884913 {ECO:0000313|EMBL:ASY29757.1, ECO:0000313|Proteomes:UP000217167};
RN [1] {ECO:0000313|EMBL:ASY29757.1, ECO:0000313|Proteomes:UP000217167}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMS-IIB-60 {ECO:0000313|EMBL:ASY29757.1};
RA Neuenschwander S.M., Salcher M., Ghai R., Pernthaler J.;
RT "High microdiversification within the ubiquitous acI lineage of
RT Actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Required for activation of the Xer recombinase, allowing
CC activation of chromosome unlinking by recombination.
CC {ECO:0000256|ARBA:ARBA00024986}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP016783; ASY29757.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A249LL77; -.
DR Proteomes; UP000217167; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 409..609
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT BINDING 426..433
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 759 AA; 82180 MW; 7175B23E0C6CC76F CRC64;
MSALWRTIAK ALGSTVRFLA RGARDLDPAH HRDGLAFLLL ILAIAAFAGT WFAADNFVGR
NLYAVIYGAF GRIGFFAPLL ILYFAMRLFR SPDSHKATSR IIVGVITLVV SASGLAHLLN
GSLGAVNPTG ATAMRHGGGW LGYAVAMPLE ALMTSLLAYP FLIALFCFGL LVTTATPLSS
VGIRVKNTGI WLWSKRPQRE EADFEITDTP PFETPVVAWN QHADETEEDI DEESFDEEFT
VEVPRVVQAP TATTTAPPAT GKRPEQLLLT ADSNYLLPPQ DLLRTGPAAK AKSKANDTVV
AALTEVFLQF DIDAQVTGFM RGPTVTRYEV ELGNAVKVER ITALAKNISY AVASSDVRIL
SPIPGKSAVG IEIPNTDREI VALGDVMRST VAGQDHHPML VALGKDVEGN FVCANLAKMP
HLLVAGATGA GKSSMINAMI TSILMRATPD EVRLVLIDPK RVELTAYEGI PHLITPIITN
PKKAADALTW VVREMDLRYE DLSTFGFRHI DDFNKAVRAG KVIPPPGSDR VVEPYPYLLV
IIDELADLMM VAAREVEESV VRITQLARSA GIHLVLATQR PSVDVVTGLI KANVPSRLSF
ATSSLADSRV ILDSPGAEKL VGQGDGLFIP MGASRAIRIQ GAYVSEREIE AVTNHVKKQL
SPRYREDVTV APQSSMMVDK EIGDDLDLLL QAIELVVGTQ FGSTSMLQRK LRVGFAKAGR
LMDLMESRGI VGPSEGSKAR VVMVKPDELD SVLATLRDY
//
