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Database: UniProt
Entry: A0A249SPH6_9BACT
LinkDB: A0A249SPH6_9BACT
Original site: A0A249SPH6_9BACT 
ID   A0A249SPH6_9BACT        Unreviewed;       799 AA.
AC   A0A249SPH6;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   08-MAY-2019, entry version 8.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:ASZ09530.1};
GN   ORFNames=CK934_00325 {ECO:0000313|EMBL:ASZ09530.1};
OS   Chitinophaga sp. MD30.
OC   Bacteria; Bacteroidetes; Chitinophagia; Chitinophagales;
OC   Chitinophagaceae; Chitinophaga.
OX   NCBI_TaxID=2033437 {ECO:0000313|EMBL:ASZ09530.1, ECO:0000313|Proteomes:UP000217148};
RN   [1] {ECO:0000313|EMBL:ASZ09530.1, ECO:0000313|Proteomes:UP000217148}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MD30 {ECO:0000313|EMBL:ASZ09530.1,
RC   ECO:0000313|Proteomes:UP000217148};
RA   Wan X., Darris M., Hou S., Donachie S.P.;
RT   "Draft genome sequence of a novel Chitinophaga sp., MD30, isolated
RT   from a biofilm in an air conditioner condensate pipe.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; CP023254; ASZ09530.1; -; Genomic_DNA.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000217148; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 2.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000217148};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296};
KW   Reference proteome {ECO:0000313|Proteomes:UP000217148}.
FT   DOMAIN        7    205       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      208    307       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   DOMAIN      387    439       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   799 AA;  88034 MW;  51476F2D50478B3C CRC64;
     MKRHINKVAV LGSGVMGSRI ACHFAGIGVQ VLLLDIQPKE LTPAEQAKGA TLDNPAVKNR
     IVNDALQATL KANPSPVFSK EAIRQIHTGN FTDDMHRIAG CDWIIEVVVE NLEIKSKVFE
     QVEQHRRPGT LITSNTSGIP IHLMTDGRSE DFKKHFCGTH FFNPPRYLRL LEIIPTTYTD
     PEIVNFLMEY GDLFLGKTTV LCKDTPAFIA NRIGVFSIMA IFHIMEEMAL AIDEIDLLTG
     PIIGRPKSAT FRTADVVGID TLVRVAKGVS ENSPEDEARD IFNIPAFLQQ VVTNNWLGDK
     TGQGFYKKVK GNTGKEILTL NLQTMEYGPK QKARFESISA AKAIEDLKER IRLLSAATDK
     AGEFYRLFHA YLFSYISFRI PATADDIYKV DDAMKAGFGW EIGPFETWDL IGIDTGIRAA
     DESGRGVAPW VKTMLEKGHN TFYKIENGSK QYYDPATATY KTIPGTASFI ILENRAANTV
     WQNNACRLYD LGDGTACIDW KTKMNTIGAA VLEGVNKAID IAERDFRGLV IGNDGANFSA
     GADVNMMFSL ASGQQYEDLD KAIRWFQQTT MRIRYSDIPV VLAAHGLTIG GGCEMSLHAD
     KVQAAAETYI GLVEMGIGII PGGGGSKELT LRASDEFKEG RIEEEPLKDY FMTIATAKVS
     TSAHEGFGMN ILRKGRDEIT MNQHRLIAEA KNSAIALANE GYTRPLERKD IKVLGRSALG
     ALLAGINGML TGRYISEHDA KVAGKLAYVM CGGDLSEPSR VSEQYLLDLE REAVLSLCTE
     PKSLERMQSV LTNGKPIRN
//
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