ID A0A250KNP2_9GAMM Unreviewed; 511 AA.
AC A0A250KNP2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=protein-serine/threonine phosphatase {ECO:0000256|ARBA:ARBA00013081};
DE EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
GN ORFNames=sS8_1194 {ECO:0000313|EMBL:BBA33156.1};
OS Methylocaldum marinum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylocaldum.
OX NCBI_TaxID=1432792 {ECO:0000313|EMBL:BBA33156.1, ECO:0000313|Proteomes:UP000266313};
RN [1] {ECO:0000313|EMBL:BBA33156.1, ECO:0000313|Proteomes:UP000266313}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S8 {ECO:0000313|EMBL:BBA33156.1,
RC ECO:0000313|Proteomes:UP000266313};
RA Takeuchi M., Kamagata Y., Hiraoka S., Oshima K., Hattori M., Iwasaki W.;
RT "Genome sequencing of Methylocaldum marinum.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001512};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001482};
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DR EMBL; AP017928; BBA33156.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A250KNP2; -.
DR KEGG; mmai:sS8_1194; -.
DR OrthoDB; 9801841at2; -.
DR Proteomes; UP000266313; Chromosome.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IEA:InterPro.
DR CDD; cd00143; PP2Cc; 1.
DR Gene3D; 3.40.1730.10; pa0076 domain; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR InterPro; IPR015655; PP2C.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR InterPro; IPR017748; TagF.
DR InterPro; IPR038225; TagF_sf.
DR NCBIfam; TIGR03373; VI_minor_4; 1.
DR PANTHER; PTHR47992:SF267; ALPHABET, ISOFORM E; 1.
DR PANTHER; PTHR47992; PROTEIN PHOSPHATASE; 1.
DR Pfam; PF13672; PP2C_2; 1.
DR Pfam; PF09867; TagF_N; 1.
DR SMART; SM00331; PP2C_SIG; 1.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS51746; PPM_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000266313}.
FT DOMAIN 279..510
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT REGION 248..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 511 AA; 55974 MW; 2E4E27FE92C3414F CRC64;
MNRPAQTGFY GKLPALGDFV SRRLPRHFID NWDQWLQSAM AASREQLGIA WLDVYLTSPI
WRFGLGAGVC GPSAWAGVLM PSVDKVGRYY PLTLAAPVSE PQCLPFLFHP GCNWFDTLET
LALSGLENDF DLAEFDRELE NRFLPDFVEE GYDISASARS SGSGKFALHF EMENLRQSSD
AFMGLSGCLL DRFLPAYSLW STSGSEHIET SFLVCEGLPP IDAFVALMTG SWEQRGWVIS
TRRLPGLSLR NSGDPAKSSE MGRSPMPQNP SAAPQRLVSH GISVVGKRRK LNEDAFIERA
DIGLWAVADG MGGHQAGEVA SRAIVDALAA QPAASDLEEF AKSVASTLQR VNSELWELGR
QSASGQIIGS TVVVLLAVGH RCACLWAGDS RLYRHRAGRT EQLTHDHSPI GELSGFEILA
DEKRTEREHC NIITRAVGAD SELELDMIKF DISEGDTFLL CSDGLDKEAG RIEIEEILQT
GDSRERAESL IALAMDRGAR DNVTVIVVQA P
//
