ID A0A250KPW9_9GAMM Unreviewed; 777 AA.
AC A0A250KPW9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:BBA33648.1};
GN ORFNames=sS8_1691 {ECO:0000313|EMBL:BBA33648.1};
OS Methylocaldum marinum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylocaldum.
OX NCBI_TaxID=1432792 {ECO:0000313|EMBL:BBA33648.1, ECO:0000313|Proteomes:UP000266313};
RN [1] {ECO:0000313|EMBL:BBA33648.1, ECO:0000313|Proteomes:UP000266313}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S8 {ECO:0000313|EMBL:BBA33648.1,
RC ECO:0000313|Proteomes:UP000266313};
RA Takeuchi M., Kamagata Y., Hiraoka S., Oshima K., Hattori M., Iwasaki W.;
RT "Genome sequencing of Methylocaldum marinum.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AP017928; BBA33648.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A250KPW9; -.
DR KEGG; mmai:sS8_1691; -.
DR OrthoDB; 9761531at2; -.
DR Proteomes; UP000266313; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000266313};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 36..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..488
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 527..713
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 777 AA; 85120 MW; 68D4D3F0FBC0E404 CRC64;
MKFSIPQNRY PAVVSVAIAL VCGASCVQLL PFLPGAWAFA LVGVVLSVAA YFRLHIPAAF
LCGILWALAV AGTRLDPSLP NSSERQTATI EGVILTIPQA FDHGFRFDFD IQRTIEPAEL
ILPSRVRLSW YDHRTSLKAG ERWQLRVKLK PPHGMLNPGG LDYERWLFAQ GIRAVGYVTE
SPDNRRLNVP DLPYSFEVWR QALYDRLSAT LDGEPLAGIV KALIMGAADD ISPAQWDVLR
RTGTTHLVVI SGSHIGLVAG FVFFLIRRAW SSLATMRWSP PTVAAVAAFT AALLYSALAD
FAIPTQRAVI MIGIVMGAVI AQRHLSGFRV LATALLAVVL YDPLAVLAPG FWLSFAAVAL
ILFVVSYRRG KLRGWRAMLR VNWATSLGLA PLLMLFFQQV SLISPIANLF AVPLIGLLLI
PLCLTGALLL PILPLAGEAL LILASRLLEW TWPILLWLAE LPAAQWIHAE PPLWTIPLAL
AGFVLLLAPR GIPARWLGLV LAVPALTAQP ASPPQAGFRL TVLDVGQGLG VAVETREHLM
IFDTGARYGS RFDIGSAVIE PYLRHRGIER IDALIVSHGD NDHIGGAPSL LKRFTVGRTY
TSVPEKLAEF PTETCKAEQF WEWDGVKFEM LGPIEKSPHE NDNSCVLKIS GAGGSALLTG
DIEKTGERLL VERYGRGLTS DILVVPHHGS KTSSSLDFLT LVKPRFALIP AGYLNRYGFP
HRPVLKRYRD LAIPVLNTAE AGALSILIGD GRKDLKVESY RKESGRYWNA HPKTTTE
//
