ID A0A250VFH4_STROL Unreviewed; 403 AA.
AC A0A250VFH4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Precorrin-6y C5,15-methyltransferase (Decarboxylating), subunit CbiE {ECO:0000313|EMBL:GAX52953.1};
GN ORFNames=SO3561_04472 {ECO:0000313|EMBL:GAX52953.1};
OS Streptomyces olivochromogenes.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1963 {ECO:0000313|EMBL:GAX52953.1, ECO:0000313|Proteomes:UP000217446};
RN [1] {ECO:0000313|Proteomes:UP000217446}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 3561 {ECO:0000313|Proteomes:UP000217446};
RA Dohra H., Kodani S.;
RT "Streptomyces olivochromogenes NBRC 3561 whole genome shotgun sequence.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAX52953.1}.
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DR EMBL; BDQI01000008; GAX52953.1; -; Genomic_DNA.
DR RefSeq; WP_067365808.1; NZ_KQ948453.1.
DR AlphaFoldDB; A0A250VFH4; -.
DR STRING; 1963.AQJ27_11395; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000217446; Unassembled WGS sequence.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11644; Precorrin-6Y-MT; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR012818; CbiE.
DR InterPro; IPR006365; Cbl_synth_CobL.
DR InterPro; IPR041698; Methyltransf_25.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR02467; CbiE; 1.
DR PANTHER; PTHR43182; COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING); 1.
DR PANTHER; PTHR43182:SF1; COBALT-PRECORRIN-7 C(5)-METHYLTRANSFERASE; 1.
DR Pfam; PF13649; Methyltransf_25; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR PIRSF; PIRSF036428; CobL; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:GAX52953.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000217446};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:GAX52953.1}.
FT DOMAIN 15..182
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 258..315
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13649"
SQ SEQUENCE 403 AA; 42077 MW; 8248B629972F49DE CRC64;
MADRVTVIGW DGSPLTAAAR SALGAATLVA GAAHHLALPE VPRAAERIRL GSVSLAARRI
AGHRGSAVVL ADGDPGFFGV VRTLRAPEFG LEVEVVPAVS SVAAAFARAG MPWDDAQVVV
AHRRTLRRAV NVCRAHTKVA VLTSPGAGPA ELGLLLEGVH RTFVICEELG TASERVTILT
SDKAADHTWR DPNVVIVIGG FVATAEDGGW IAGRDPGTGP RGWALPAQAY GGALGEGETD
LLRAAQLARL GPRVGDLVWD IGSGSGAFAT EAARTGAAVI AVDRNPGSCA RTEDSARRYG
VQMQIVHGTA PHVLENLPEP DVVRVGGGGA QVVSAVADRR PQRIVTHAAT RDAAELVGRD
LSEHGYQVEC ALIQSVELDT RAWTETERSV AFLLTGRLPD RNP
//
