ID A0A250VQ77_STROL Unreviewed; 558 AA.
AC A0A250VQ77;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Fused response regulator/thioredoxin-disulfide reductase {ECO:0000313|EMBL:GAX56236.1};
GN ORFNames=SO3561_07803 {ECO:0000313|EMBL:GAX56236.1};
OS Streptomyces olivochromogenes.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1963 {ECO:0000313|EMBL:GAX56236.1, ECO:0000313|Proteomes:UP000217446};
RN [1] {ECO:0000313|Proteomes:UP000217446}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 3561 {ECO:0000313|Proteomes:UP000217446};
RA Dohra H., Kodani S.;
RT "Streptomyces olivochromogenes NBRC 3561 whole genome shotgun sequence.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide +
CC H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA-
CC COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000849};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAX56236.1}.
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DR EMBL; BDQI01000024; GAX56236.1; -; Genomic_DNA.
DR RefSeq; WP_067381225.1; NZ_KQ948474.1.
DR AlphaFoldDB; A0A250VQ77; -.
DR STRING; 1963.AQJ27_41770; -.
DR Proteomes; UP000217446; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR48105:SF5; BLR1248 PROTEIN; 1.
DR PANTHER; PTHR48105; THIOREDOXIN REDUCTASE 1-RELATED-RELATED; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00469; PNDRDTASEII.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW Reference proteome {ECO:0000313|Proteomes:UP000217446}.
FT DOMAIN 11..134
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 68
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 558 AA; 59732 MW; 393C52B7FDA842CB CRC64;
MAQAAATART VILTVDDDPG VSRAVARDLR RRYGESHRIV RAESGDAALD ALKELKLRGD
QVAVILADYR MPQMNGIEFL EQALDVYPGA RRVLLTAYAD TNAAIDAINV IDLDHYLLKP
WDPPEEKLYP VLDDLLDAWR TSDYRPVATC KVVGHRWSAR SSDVREFLAR NQVPYRWYSS
DTPEGQRLLS AAGQDGERLP LVITPDGTPL VEPDDPDLAA RVGLATTPTS EFYDLVVIGG
GPAGLGAAVY GASEGLRTVL VERSATGGQA GQSSRIENYL GFPDGVSGGQ LTDRARRQAA
KFGAEILTAR EVTGLEVTGA SRTIRFSDGS AISAHAVILA TGVSYRQLQA PGLADLTGCG
VFYGSALTEA AACQGHDVYI VGGANSAGQA AMYLSRGAKS VTLLVRGTSL SASMSHYLIQ
QIEEASNITV RTCTVVDAAH GTDHLEQLTL RDVTSGHTEL VDAQWMFVFI GAAPLTDWLE
GTVLRDGRGF IPSGPDMTID GQPPKGWELD RPPYHLETNI PGVFVAGDAR AESAKRVASA
VGEGAMAVML VHRYLEQS
//
