ID A0A250X4W3_9CHLO Unreviewed; 365 AA.
AC A0A250X4W3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=GDP-mannose 4,6-dehydratase {ECO:0000256|ARBA:ARBA00011989};
DE EC=4.2.1.47 {ECO:0000256|ARBA:ARBA00011989};
GN ORFNames=CEUSTIGMA_g5243.t1 {ECO:0000313|EMBL:GAX77800.1};
OS Chlamydomonas eustigma.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=1157962 {ECO:0000313|EMBL:GAX77800.1, ECO:0000313|Proteomes:UP000232323};
RN [1] {ECO:0000313|EMBL:GAX77800.1, ECO:0000313|Proteomes:UP000232323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-2499 {ECO:0000313|EMBL:GAX77800.1,
RC ECO:0000313|Proteomes:UP000232323};
RA Hirooka S., Hirose Y., Kanesaki Y., Higuchi S., Fujiwara T., Onuma R.,
RA Era A., Ohbayashi R., Uzuka A., Nozaki H., Yoshikawa H., Miyagishima S.Y.;
RT "Acidophilic green algal genome provides insights into adaptation to an
RT acidic environment.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC Evidence={ECO:0000256|ARBA:ARBA00001937};
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. GDP-mannose 4,6-dehydratase subfamily.
CC {ECO:0000256|ARBA:ARBA00009263}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAX77800.1}.
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DR EMBL; BEGY01000027; GAX77800.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A250X4W3; -.
DR STRING; 1157962.A0A250X4W3; -.
DR OrthoDB; 5484740at2759; -.
DR Proteomes; UP000232323; Unassembled WGS sequence.
DR GO; GO:0008446; F:GDP-mannose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0042350; P:GDP-L-fucose biosynthetic process; IEA:UniProt.
DR GO; GO:0019673; P:GDP-mannose metabolic process; IEA:InterPro.
DR CDD; cd05260; GDP_MD_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR HAMAP; MF_00955; GDP_Man_dehydratase; 1.
DR InterPro; IPR006368; GDP_Man_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR01472; gmd; 1.
DR PANTHER; PTHR43715:SF1; GDP-MANNOSE 4,6 DEHYDRATASE; 1.
DR PANTHER; PTHR43715; GDP-MANNOSE 4,6-DEHYDRATASE; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000232323}.
FT DOMAIN 6..341
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
SQ SEQUENCE 365 AA; 40932 MW; 08A535A05010EBFB CRC64;
MAKVALITGV CGQDGSYLAE LLLAKGYLVH GLKRRGSSFN HPRLEHILDP GYPNAENFRL
HYSDLIDGTS LANLLKEVMP DEIYNLAAQS HVKVSFELPE YTAMATGMGA LNLLEAIKAA
GLMDKVRVYQ ASSSEMFGKV HEVPQKETTP FHPRSPYGAA KVYAYWIFVN YRESYNMFCS
NGILFNHESP RRGETFVTRK ITMAAARIKL GIQDCLFLGN MDSLRDWGHA RDYVHAMWLI
LQHDKPDDFV IATGKMTSVR DFCQMSFTEM GLPLRFEGEG VNEVCIIASG KRAGQVVVRV
SEKYFRPAEV DQLLGDPTKA KTLLGWDPSK LTSVEDLCKD MVNSDFMTAQ EELDLKAKRK
GRMPA
//