ID A0A250XI35_9CHLO Unreviewed; 561 AA.
AC A0A250XI35;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=6-phosphofructo-2-kinase domain-containing protein {ECO:0000259|Pfam:PF01591};
GN ORFNames=CEUSTIGMA_g10167.t1 {ECO:0000313|EMBL:GAX82741.1};
OS Chlamydomonas eustigma.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=1157962 {ECO:0000313|EMBL:GAX82741.1, ECO:0000313|Proteomes:UP000232323};
RN [1] {ECO:0000313|EMBL:GAX82741.1, ECO:0000313|Proteomes:UP000232323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-2499 {ECO:0000313|EMBL:GAX82741.1,
RC ECO:0000313|Proteomes:UP000232323};
RA Hirooka S., Hirose Y., Kanesaki Y., Higuchi S., Fujiwara T., Onuma R.,
RA Era A., Ohbayashi R., Uzuka A., Nozaki H., Yoshikawa H., Miyagishima S.Y.;
RT "Acidophilic green algal genome provides insights into adaptation to an
RT acidic environment.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAX82741.1}.
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DR EMBL; BEGY01000085; GAX82741.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A250XI35; -.
DR STRING; 1157962.A0A250XI35; -.
DR OrthoDB; 2013830at2759; -.
DR Proteomes; UP000232323; Unassembled WGS sequence.
DR GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR GO; GO:0006000; P:fructose metabolic process; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR003094; 6Pfruct_kin.
DR InterPro; IPR013079; 6Phosfructo_kin.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001345; PG/BPGM_mutase_AS.
DR PANTHER; PTHR10606:SF44; 6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM; 1.
DR PANTHER; PTHR10606; 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE; 1.
DR Pfam; PF01591; 6PF2K; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR PRINTS; PR00991; 6PFRUCTKNASE.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00175; PG_MUTASE; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000232323}.
FT DOMAIN 119..334
FT /note="6-phosphofructo-2-kinase"
FT /evidence="ECO:0000259|Pfam:PF01591"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 349..356
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
FT BINDING 403
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 561 AA; 62472 MW; 0AFF73343CE01B0B CRC64;
MWDHVTRAKD SEKSIESTPR STSAGGHATP SFSAFNAVIK SSFSGTSSAE VSPSKPNLEK
ILRQPVNFRD VVITTTQSSI SGGLNSPTKS VEIDLHASTS VGNLAEVDSL GSLYSEQPQY
ASVQRSKMVI IMVGLPGRGK TFVCNKLKCY LNWLGHVTGH FNVGNYRRNQ KLGDLTQDAS
FFCHTNGAGL ELRQKALDSA LDDMMRWLNT GSGQVAIFDA TNTTASRRQL LRDKLHGRCQ
YLFIESICND METLERNYMN KLMYSPDYAG VNVEEALRDF KARIQAYEDV YEPITDRSFH
YIKLIDMVTG RGYMDINRIS GYIPGKLVFF LMQVCRAGLG NARKIWLTRH GESEYNVLKL
IGGDSNISGE GEKYATALPK VLEARLPQGE ATPLQVWTST LKRTIQTAQH LPFAKLRWKA
LDEIDAGVCD GMTYEDIAEK MPEEFAARKS DKLGYRYPSG ESYMDVIQRL EPVIIEIERQ
KDSVCIVAHQ AILRVIYGYF MAVSPEEIPR LSIPLHTLIE LTPMPDGQMS VQMLPVDINA
DPSTLLENLA SNPSPLPVLA S
//
