ID A0A251K0S2_MANES Unreviewed; 1230 AA.
AC A0A251K0S2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=MANES_10G122800 {ECO:0000313|EMBL:OAY39797.1};
OS Manihot esculenta (Cassava) (Jatropha manihot).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC Manihot.
OX NCBI_TaxID=3983 {ECO:0000313|EMBL:OAY39797.1, ECO:0000313|Proteomes:UP000091857};
RN [1] {ECO:0000313|EMBL:OAY39797.1, ECO:0000313|Proteomes:UP000091857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AM560-2 {ECO:0000313|Proteomes:UP000091857};
RC TISSUE=Leaf {ECO:0000313|EMBL:OAY39797.1};
RA Bredeson J.V., Prochnik S.E., Lyons J.B., Schmutz J., Grimwood J.,
RA Vrebalov J., Bart R.S., Amuge T., Ferguson M.E., Green R., Putnam N.,
RA Stites J., Rounsley S., Rokhsar D.S.;
RT "WGS assembly of Manihot esculenta.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; CM004396; OAY39796.1; -; Genomic_DNA.
DR EMBL; CM004396; OAY39797.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251K0S2; -.
DR STRING; 3983.A0A251K0S2; -.
DR EnsemblPlants; OAY39796; OAY39796; MANES_10G122800.
DR EnsemblPlants; OAY39797; OAY39797; MANES_10G122800.
DR Gramene; OAY39796; OAY39796; MANES_10G122800.
DR Gramene; OAY39797; OAY39797; MANES_10G122800.
DR OMA; VNWSDHA; -.
DR OrthoDB; 1114285at2759; -.
DR Proteomes; UP000091857; Chromosome lg10.
DR GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009378; F:four-way junction helicase activity; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF153; ATP-DEPENDENT DNA HELICASE Q-LIKE 4A; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000091857}.
FT DOMAIN 466..641
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 666..816
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 681..723
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 1025..1107
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 102..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1190..1217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1203..1217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1230 AA; 138486 MW; 815925F3111D3A78 CRC64;
MRKNLSNSGQ DNKCNEKLPE VNWSQHANAH DNFSSQKKFL SSNFLFSLEG QKPCIEGSMA
MRLTCCQIQS LQRLQSQEVE KAWHTLCTLQ ISCRNYLQPG KTGPLKNARN DSLQDVGKPT
LHSSSNRRKD SEDMHANQNF RDSSLRNNES TRYTGNVFPQ DNARAAEAGS DMGRQNNIKG
SAINNTQSKA FVGLMSNHIV HTKQSKESPE ALADFIDDDD LLGNIDVDQI VMEHYQSTST
PQPSVSKFPP ITPTADKNNF MRSEETFLPS ELCQNCNHGF KLGLCPEAAN HLQEMKDMLI
SVSNELLDNT ANLSPAQIEK LRQDRLQLNK QIQQLEKYLC DGERQNSHFS ASTATRNFQY
ETPQSAACRI DPPRFNAQFQ LPNGPGGHEN WNLPSVSFSS VDRFGLSSGP VDREPYIPKF
IEVNYIEGSN DPKWSSTNFS WTKKLEAYNK KVFGNHSFRP NQREVINASM SGFDVFVLMP
TGGGKSLTYQ LPALISPGIT LVISPLVSLI QDQIMHLLQA NISATYLSAN MDWTEQQEIL
RELCSDYCKY KLLYVTPEKV AKSDVLLRHL DSLNARGLLA RIVIDEAHCV SQWGHDFRPD
YKELGILKKK FGKTPVLALT ATATASVKED VVQALGLVDC IVFRQSFNRP NLWYSVIPKT
KKCLDDIDQF IKGNHFDECG IIYCLSRMDC EKVAKKLQEC GHKAAFYHGN MDSAQRAYIQ
KQWSKDEINI ICATVAFGMG INKPDVRFVI HHSLPKSIEG YHQECGRAGR DGQRSSCVLY
YSYSDYIRVK HMIIQGQIEQ NPWTPGYNRT NMTNSERVLE KNTENVLRMV SYCENDVDCR
RLLQLLHFGE KFDSGNCKKT CDNCSKIKTL VEKDVTEIAK QLVELVKLTG QQFSSSHILE
VYRGSLNQYV KRYKHETLSL HGAGKHLAKG EASRILRHLV TEDFLVEDVK KSDIYGSVSS
VLKVNESKAY NLCSSGQTIV LRFPSAVKVS KLSKYDATPA KGTLTYGEQS PLVDAPAQPQ
SEVDLSLSAK LYSALRMLRT ILVKEAGDGV MAYHIFGNAT LQHLCKRIPR TKEELLEING
IGKAKVSKYG DRLLETIEST IREHHNTDKN SSGSNDSTDS IKRRRDATRA AKLNVEEEDD
FTKSTGRSKK RAAKLQNKDT EVYNARETDQ NQCLDDDLDF EDSCYDHETN GSAVEADKNG
TGRVLPSWST PGNKIKSSNH NLFQEYAMNS
//
