ID A0A251LEJ6_MANES Unreviewed; 103 AA.
AC A0A251LEJ6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Histone H4 {ECO:0000256|RuleBase:RU000528};
GN ORFNames=MANES_01G069400 {ECO:0000313|EMBL:OAY59902.1},
GN MANES_02G030600 {ECO:0000313|EMBL:OAY56602.1}, MANES_04G028700
GN {ECO:0000313|EMBL:OAY51739.1}, MANES_04G032600
GN {ECO:0000313|EMBL:OAY51785.1}, MANES_06G082200
GN {ECO:0000313|EMBL:OAY47472.1}, MANES_07G114600
GN {ECO:0000313|EMBL:OAY46073.1}, MANES_10G039100
GN {ECO:0000313|EMBL:OAY38731.1}, MANES_11G137100
GN {ECO:0000313|EMBL:OAY37892.1}, MANES_14G087900
GN {ECO:0000313|EMBL:OAY31148.1};
OS Manihot esculenta (Cassava) (Jatropha manihot).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC Manihot.
OX NCBI_TaxID=3983 {ECO:0000313|EMBL:OAY56602.1, ECO:0000313|Proteomes:UP000091857};
RN [1] {ECO:0000313|EMBL:OAY56602.1, ECO:0000313|Proteomes:UP000091857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AM560-2 {ECO:0000313|Proteomes:UP000091857};
RC TISSUE=Leaf {ECO:0000313|EMBL:OAY56602.1};
RA Bredeson J.V., Prochnik S.E., Lyons J.B., Schmutz J., Grimwood J.,
RA Vrebalov J., Bart R.S., Amuge T., Ferguson M.E., Green R., Putnam N.,
RA Stites J., Rounsley S., Rokhsar D.S.;
RT "WGS assembly of Manihot esculenta.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC {ECO:0000256|RuleBase:RU000528}.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA. {ECO:0000256|RuleBase:RU000528}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the histone H4 family.
CC {ECO:0000256|ARBA:ARBA00006564, ECO:0000256|RuleBase:RU000528}.
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DR EMBL; CM004400; OAY31148.1; -; Genomic_DNA.
DR EMBL; CM004397; OAY37892.1; -; Genomic_DNA.
DR EMBL; CM004396; OAY38731.1; -; Genomic_DNA.
DR EMBL; CM004393; OAY46073.1; -; Genomic_DNA.
DR EMBL; CM004392; OAY47472.1; -; Genomic_DNA.
DR EMBL; CM004390; OAY51739.1; -; Genomic_DNA.
DR EMBL; CM004390; OAY51785.1; -; Genomic_DNA.
DR EMBL; CM004388; OAY56602.1; -; Genomic_DNA.
DR EMBL; CM004387; OAY59902.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251LEJ6; -.
DR SMR; A0A251LEJ6; -.
DR STRING; 3983.A0A251LEJ6; -.
DR EnsemblPlants; OAY31148; OAY31148; MANES_14G087900.
DR EnsemblPlants; OAY37892; OAY37892; MANES_11G137100.
DR EnsemblPlants; OAY38731; OAY38731; MANES_10G039100.
DR EnsemblPlants; OAY46073; OAY46073; MANES_07G114600.
DR EnsemblPlants; OAY47472; OAY47472; MANES_06G082200.
DR EnsemblPlants; OAY51739; OAY51739; MANES_04G028700.
DR EnsemblPlants; OAY51785; OAY51785; MANES_04G032600.
DR EnsemblPlants; OAY56602; OAY56602; MANES_02G030600.
DR EnsemblPlants; OAY59902; OAY59902; MANES_01G069400.
DR Gramene; OAY31148; OAY31148; MANES_14G087900.
DR Gramene; OAY37892; OAY37892; MANES_11G137100.
DR Gramene; OAY38731; OAY38731; MANES_10G039100.
DR Gramene; OAY46073; OAY46073; MANES_07G114600.
DR Gramene; OAY47472; OAY47472; MANES_06G082200.
DR Gramene; OAY51739; OAY51739; MANES_04G028700.
DR Gramene; OAY51785; OAY51785; MANES_04G032600.
DR Gramene; OAY56602; OAY56602; MANES_02G030600.
DR Gramene; OAY59902; OAY59902; MANES_01G069400.
DR OMA; QKEHING; -.
DR OrthoDB; 518774at2759; -.
DR Proteomes; UP000091857; Chromosome lg1.
DR Proteomes; UP000091857; Chromosome lg10.
DR Proteomes; UP000091857; Chromosome lg11.
DR Proteomes; UP000091857; Chromosome lg14.
DR Proteomes; UP000091857; Chromosome lg2.
DR Proteomes; UP000091857; Chromosome lg4.
DR Proteomes; UP000091857; Chromosome lg6.
DR Proteomes; UP000091857; Chromosome lg7.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central.
DR CDD; cd00076; H4; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR001951; Histone_H4.
DR InterPro; IPR019809; Histone_H4_CS.
DR PANTHER; PTHR10484; HISTONE H4; 1.
DR PANTHER; PTHR10484:SF0; HISTONE H4; 1.
DR Pfam; PF15511; CENP-T_C; 1.
DR PRINTS; PR00623; HISTONEH4.
DR SMART; SM00417; H4; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR PROSITE; PS00047; HISTONE_H4; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU000528};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000528};
KW Nucleosome core {ECO:0000256|ARBA:ARBA00023269,
KW ECO:0000256|RuleBase:RU000528};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU000528};
KW Reference proteome {ECO:0000313|Proteomes:UP000091857}.
FT DOMAIN 39..96
FT /note="CENP-T/Histone H4 histone fold"
FT /evidence="ECO:0000259|Pfam:PF15511"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 103 AA; 11409 MW; A9FD57725A2A7598 CRC64;
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK
IFLENVIRDA VTYTEHARRK TVTAMDVVYA LKRQGRTLYG FGG
//
