ID A0A251MS47_PRUPE Unreviewed; 1049 AA.
AC A0A251MS47;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=PRUPE_8G031800 {ECO:0000313|EMBL:ONH90041.1};
OS Prunus persica (Peach) (Amygdalus persica).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX NCBI_TaxID=3760 {ECO:0000313|EMBL:ONH90041.1, ECO:0000313|Proteomes:UP000006882};
RN [1] {ECO:0000313|EMBL:ONH90041.1, ECO:0000313|Proteomes:UP000006882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nemared {ECO:0000313|Proteomes:UP000006882};
RX PubMed=23525075; DOI=10.1038/ng.2586;
RA Verde I., Abbott A.G., Scalabrin S., Jung S., Shu S., Marroni F.,
RA Zhebentyayeva T., Dettori M.T., Grimwood J., Cattonaro F., Zuccolo A.,
RA Rossini L., Jenkins J., Vendramin E., Meisel L.A., Decroocq V.,
RA Sosinski B., Prochnik S., Mitros T., Policriti A., Cipriani G., Dondini L.,
RA Ficklin S., Goodstein D.M., Xuan P., Del Fabbro C., Aramini V., Copetti D.,
RA Gonzalez S., Horner D.S., Falchi R., Lucas S., Mica E., Maldonado J.,
RA Lazzari B., Bielenberg D., Pirona R., Miculan M., Barakat A., Testolin R.,
RA Stella A., Tartarini S., Tonutti P., Arus P., Orellana A., Wells C.,
RA Main D., Vizzotto G., Silva H., Salamini F., Schmutz J., Morgante M.,
RA Rokhsar D.S.;
RT "The high-quality draft genome of peach (Prunus persica) identifies unique
RT patterns of genetic diversity, domestication and genome evolution.";
RL Nat. Genet. 45:487-494(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; CM007658; ONH90041.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251MS47; -.
DR EnsemblPlants; ONH90041; ONH90041; PRUPE_8G031800.
DR Gramene; ONH90041; ONH90041; PRUPE_8G031800.
DR eggNOG; ENOG502R41B; Eukaryota.
DR Proteomes; UP000006882; Chromosome g8.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF559; DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS) FAMILY; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 3.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000006882};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..82
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1049 AA; 119059 MW; 78D8866248063B4A CRC64;
MKSKSTVLPV FYHVDPSDIR KQTGSFACAF AEHEERFRED RERVKSWRAA LTEVANLSGF
DSKNECERKL IENIVEWVWE KVHHRFKLLG STELVGMKFI REQVDLLLAH PTDDVRFVGI
WGMGGIGKTT IAKLVYDRIS IHYEVNSFLA NVREVSQRGD LVNLQRQLLS PILKDQFTQV
WDEQWGTSVI KNCLYNKKVL LILDDVSESS QLEKLAGEKD WFGKGSIIII TTRDKRLLVK
HDIHISCKVE ALGNDDALVL FSLNAFKKNE PEEGFLELSK GFVSYAKGLP LALKLLGCLV
YKRDQDEWRS ELDKLQKIPK SEIIDLLKIS YDRLDEMNKD IFLDVAFFHK GKDKEEVIEI
LDSCGLCGCV GINDLVQKSL LTISHRNVEM HDLIQEMALE IVRRECSEEP GRRSRLCNCD
DISHVFINNT ATNKIKGIAL GMARLEMGDW NCEAFSKMCN LKILEFDNVI ISSSPRILPN
SLRSIKWSLY PSKFLPSGFQ PNFLIALEMC NSKLVRLWDG RKDLPNLKKM KLVGSENLTT
TPDFSGVPNL ELLDFQFCKN LVEIHPSIVD LKCLESLNLG FCSKLKKIPE FSGQMKNLSF
LLLSGTSIEK LSSSIGCLVD LTILLLEDCK NLTGLPSEIC NLKSLTELEV SGCSKIDKLP
ENMGEMESLT ELQLYETSIR QLPRSIVGLK KLMSLSLGGR SGSQPNKSRF WWGLPLLNGR
KAFVLASLDG LFSLKYLDLS NCGVCEGDLP SDIGCLSSLK ELRLSGNNFV SLPASVGCLS
KLTLFWVNGC QSLEQLPDLS KLISLVDINI ANCTSLKMLP HLSSNFSLVD IHYEIHFCRF
KCANCFVLVD NEGCDSIILK MLQRYLQLQL QLQTRVFPRI YLDRFEILTP GRKIPEWFSN
QSLGDSLTVE LPTTWMGIAL CVVFEVPADL SEFLCFRITS FSQEKSTHRF SRSFKIGDVV
SDHLWVIFLS HKQFEKIYGQ IKVLFTTDYS QDIMWGDKKS CVKRCGFCLV HEQDVEQLNQ
IMMNKSIIKS TTIYPTNSAD AQGQHCHDD
//
