ID A0A251NAG0_PRUPE Unreviewed; 511 AA.
AC A0A251NAG0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=UMP kinase {ECO:0000256|ARBA:ARBA00012899};
DE EC=2.7.4.22 {ECO:0000256|ARBA:ARBA00012899};
DE AltName: Full=Uridine monophosphate kinase {ECO:0000256|ARBA:ARBA00032092};
GN ORFNames=PRUPE_7G120600 {ECO:0000313|EMBL:ONH96323.1};
OS Prunus persica (Peach) (Amygdalus persica).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX NCBI_TaxID=3760 {ECO:0000313|EMBL:ONH96323.1, ECO:0000313|Proteomes:UP000006882};
RN [1] {ECO:0000313|EMBL:ONH96323.1, ECO:0000313|Proteomes:UP000006882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nemared {ECO:0000313|Proteomes:UP000006882};
RX PubMed=23525075; DOI=10.1038/ng.2586;
RA Verde I., Abbott A.G., Scalabrin S., Jung S., Shu S., Marroni F.,
RA Zhebentyayeva T., Dettori M.T., Grimwood J., Cattonaro F., Zuccolo A.,
RA Rossini L., Jenkins J., Vendramin E., Meisel L.A., Decroocq V.,
RA Sosinski B., Prochnik S., Mitros T., Policriti A., Cipriani G., Dondini L.,
RA Ficklin S., Goodstein D.M., Xuan P., Del Fabbro C., Aramini V., Copetti D.,
RA Gonzalez S., Horner D.S., Falchi R., Lucas S., Mica E., Maldonado J.,
RA Lazzari B., Bielenberg D., Pirona R., Miculan M., Barakat A., Testolin R.,
RA Stella A., Tartarini S., Tonutti P., Arus P., Orellana A., Wells C.,
RA Main D., Vizzotto G., Silva H., Salamini F., Schmutz J., Morgante M.,
RA Rokhsar D.S.;
RT "The high-quality draft genome of peach (Prunus persica) identifies unique
RT patterns of genetic diversity, domestication and genome evolution.";
RL Nat. Genet. 45:487-494(2013).
CC -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via de novo pathway;
CC UDP from UMP (UMPK route): step 1/1. {ECO:0000256|ARBA:ARBA00004791}.
CC -!- SIMILARITY: Belongs to the UMP kinase family.
CC {ECO:0000256|ARBA:ARBA00007614}.
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DR EMBL; CM007657; ONH96323.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251NAG0; -.
DR SMR; A0A251NAG0; -.
DR EnsemblPlants; ONH96323; ONH96323; PRUPE_7G120600.
DR Gramene; ONH96323; ONH96323; PRUPE_7G120600.
DR UniPathway; UPA00159; UER00275.
DR Proteomes; UP000006882; Chromosome g7.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0033862; F:UMP kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0044210; P:'de novo' CTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04254; AAK_UMPK-PyrH-Ec; 1.
DR Gene3D; 3.40.1160.10; Acetylglutamate kinase-like; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR036393; AceGlu_kinase-like_sf.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR044822; Myb_DNA-bind_4.
DR InterPro; IPR015963; Uridylate_kinase_bac.
DR PANTHER; PTHR42833; URIDYLATE KINASE; 1.
DR PANTHER; PTHR42833:SF1; URIDYLATE KINASE; 1.
DR Pfam; PF00696; AA_kinase; 1.
DR Pfam; PF13837; Myb_DNA-bind_4; 1.
DR SUPFAM; SSF53633; Carbamate kinase-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW Reference proteome {ECO:0000313|Proteomes:UP000006882}.
FT DOMAIN 145..235
FT /note="Myb/SANT-like DNA-binding"
FT /evidence="ECO:0000259|Pfam:PF13837"
FT DOMAIN 289..495
FT /note="Aspartate/glutamate/uridylate kinase"
FT /evidence="ECO:0000259|Pfam:PF00696"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 188..215
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 10..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 511 AA; 55611 MW; D32226FA8269BC0D CRC64;
MASCDDDFSI LGDESNTTHH SHLPHAPSSH QLHQPYAPPH RFATRTTPVH APPAQPILSD
KVNAVEDQAE AGDDYDDASA AAFCSNPFES GTDQNDVVAG ASEKRKEHSD ELSDGGGGGS
GSAPYSYKRS KPSSTAAIGE YRKDREEWSD SAISCLLDAY TDKFTQLNRG NLRGRDWEEV
AAIVSERCDR QRKSVDQCKN KVDNLKKRYK LERQRMNNGG VSASHWPWFK KMENIVGNSL
PGKAISDEDK GVSSPGTTPR QSKRNAMAII SPVSQMNKVK SAPSIKWRRV VFKISGAALA
GAAPNNVDSK LAMLIAREVA LACHNGVEVA IVVGGRNFFC GDAWVTATGL DRSTAYQIGM
MATVMNSVLL QSALEKMGVQ TRVQTAFSMQ EVAEPYSRQR AIRHLEKGRV VIFAGIGAGT
GNPLFSTDTA AALRALEIHA EAVLKGTNVD GVYDCNSQDN NFTFEHISFR DVVTRGATSM
DSMALTFCEE NRIPGKCILF YLYLVQIAPL S
//
