ID A0A251NCX4_PRUPE Unreviewed; 916 AA.
AC A0A251NCX4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=[histone H3]-lysine(27) N-trimethyltransferase {ECO:0000256|ARBA:ARBA00012186};
DE EC=2.1.1.356 {ECO:0000256|ARBA:ARBA00012186};
GN ORFNames=PRUPE_7G130900 {ECO:0000313|EMBL:ONH96459.1};
OS Prunus persica (Peach) (Amygdalus persica).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX NCBI_TaxID=3760 {ECO:0000313|EMBL:ONH96459.1, ECO:0000313|Proteomes:UP000006882};
RN [1] {ECO:0000313|EMBL:ONH96459.1, ECO:0000313|Proteomes:UP000006882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nemared {ECO:0000313|Proteomes:UP000006882};
RX PubMed=23525075; DOI=10.1038/ng.2586;
RA Verde I., Abbott A.G., Scalabrin S., Jung S., Shu S., Marroni F.,
RA Zhebentyayeva T., Dettori M.T., Grimwood J., Cattonaro F., Zuccolo A.,
RA Rossini L., Jenkins J., Vendramin E., Meisel L.A., Decroocq V.,
RA Sosinski B., Prochnik S., Mitros T., Policriti A., Cipriani G., Dondini L.,
RA Ficklin S., Goodstein D.M., Xuan P., Del Fabbro C., Aramini V., Copetti D.,
RA Gonzalez S., Horner D.S., Falchi R., Lucas S., Mica E., Maldonado J.,
RA Lazzari B., Bielenberg D., Pirona R., Miculan M., Barakat A., Testolin R.,
RA Stella A., Tartarini S., Tonutti P., Arus P., Orellana A., Wells C.,
RA Main D., Vizzotto G., Silva H., Salamini F., Schmutz J., Morgante M.,
RA Rokhsar D.S.;
RT "The high-quality draft genome of peach (Prunus persica) identifies unique
RT patterns of genetic diversity, domestication and genome evolution.";
RL Nat. Genet. 45:487-494(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
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DR EMBL; CM007657; ONH96459.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251NCX4; -.
DR STRING; 3760.A0A251NCX4; -.
DR EnsemblPlants; ONH96459; ONH96459; PRUPE_7G130900.
DR Gramene; ONH96459; ONH96459; PRUPE_7G130900.
DR eggNOG; KOG1079; Eukaryota.
DR OrthoDB; 902834at2759; -.
DR Proteomes; UP000006882; Chromosome g7.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0031519; C:PcG protein complex; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0046976; F:histone H3K27 methyltransferase activity; IBA:GO_Central.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0003727; F:single-stranded RNA binding; IEA:EnsemblPlants.
DR GO; GO:1990110; P:callus formation; IEA:EnsemblPlants.
DR GO; GO:0009294; P:DNA-mediated transformation; IEA:EnsemblPlants.
DR GO; GO:0031507; P:heterochromatin formation; IBA:GO_Central.
DR GO; GO:0009965; P:leaf morphogenesis; IEA:EnsemblPlants.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:EnsemblPlants.
DR GO; GO:0009909; P:regulation of flower development; IEA:EnsemblPlants.
DR GO; GO:1900055; P:regulation of leaf senescence; IEA:EnsemblPlants.
DR GO; GO:0009737; P:response to abscisic acid; IEA:EnsemblPlants.
DR GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IEA:EnsemblPlants.
DR GO; GO:0010048; P:vernalization response; IEA:EnsemblPlants.
DR CDD; cd10519; SET_EZH; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR025778; Hist-Lys_N-MeTrfase_plant.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM01114; CXC; 1.
DR SMART; SM00717; SANT; 2.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS51576; SAM_MT43_EZ; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000006882};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 653..752
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 767..882
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..909
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 916 AA; 102528 MW; B23E3B6FE2EC4061 CRC64;
MASKASPSAS ANRSEPHQEP PMTASQENMD VTRKEISLII DSLKKQVVSN RGTSIKKRME
ENRQRLAGVT NNLYKLSMER GSNRFIDIGK SVDLLTKRQK DAFALQNGID VSKDGSQEDG
HGSTAVLLES NVAVKSSVRP IKLPEVKRLP PYTTWIFLDR NQRMTEDQSV LGRRRIYYDQ
NGGEALICSD SEEEAVDEED EKRDFVESED YILSMAIKEV GFSDPVLESL AQCFSRSPSE
VKARYDTLVK EEEAVGGCKT MDNEDISQNG NYFLDKDLDA ALDSFDNLFC RRCLVFDCRL
HGCSQDLVFP AEKQPPWSSP DAENASCGPN CYRSVLKSER IARVSSGDVE EKNVTSLDGA
SAQTSTRKKS SVISARKKVK SGQSESASSN AKAISESSDS ENGPRQDATH HQTPSKTKLA
GKSGIGKRNS KRVAERVLVC MQKRQKKMVV SDSDSIVNAG LCPSDMKLRS NSCKDNEDTS
SSSQKNLKSS TSGGFRRMES PTKGRHKVVQ VDVLDGSSDE IIADPPGTSS DDNLRKEECV
DENIYKQELS DDKTWKTIEK GLFDKGIEIF GRNSCLIARN LLNGMKNCWE VFQYMNYSES
KMSCQEGDAA NSLVEGHSKG NNEARRRSRF LRRRGRVRRL KYTWKSAAYH SIRKRITERK
DQPCRQYNPC TCQTACGKQC SCLQNGTCCE KYCGCPKTCK NRFRGCHCAK SQCRSRQCPC
FAADRECDPD VCRNCWVSCG DGSLGVPNQR GDNYECRNMK LLLKQQQRVL LGRSDVSGWG
AFLKNSVGKH EYLGEYTGEL ISHREADKRG KIYDRENSSF LFNLNDQFVL DAYRKGDKLK
FANHAPDPNC YAKVIMVAGD HRVGIFAKER ITAGEELFYD YRYEPDRAPA WARKPEASGS
KKDEGAPSSG RAKKLA
//
