ID A0A251NDE3_PRUPE Unreviewed; 1213 AA.
AC A0A251NDE3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 08-NOV-2023, entry version 21.
DE RecName: Full=MutL C-terminal dimerisation domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PRUPE_7G183500 {ECO:0000313|EMBL:ONH97316.1};
OS Prunus persica (Peach) (Amygdalus persica).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX NCBI_TaxID=3760 {ECO:0000313|EMBL:ONH97316.1, ECO:0000313|Proteomes:UP000006882};
RN [1] {ECO:0000313|EMBL:ONH97316.1, ECO:0000313|Proteomes:UP000006882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nemared {ECO:0000313|Proteomes:UP000006882};
RX PubMed=23525075; DOI=10.1038/ng.2586;
RA Verde I., Abbott A.G., Scalabrin S., Jung S., Shu S., Marroni F.,
RA Zhebentyayeva T., Dettori M.T., Grimwood J., Cattonaro F., Zuccolo A.,
RA Rossini L., Jenkins J., Vendramin E., Meisel L.A., Decroocq V.,
RA Sosinski B., Prochnik S., Mitros T., Policriti A., Cipriani G., Dondini L.,
RA Ficklin S., Goodstein D.M., Xuan P., Del Fabbro C., Aramini V., Copetti D.,
RA Gonzalez S., Horner D.S., Falchi R., Lucas S., Mica E., Maldonado J.,
RA Lazzari B., Bielenberg D., Pirona R., Miculan M., Barakat A., Testolin R.,
RA Stella A., Tartarini S., Tonutti P., Arus P., Orellana A., Wells C.,
RA Main D., Vizzotto G., Silva H., Salamini F., Schmutz J., Morgante M.,
RA Rokhsar D.S.;
RT "The high-quality draft genome of peach (Prunus persica) identifies unique
RT patterns of genetic diversity, domestication and genome evolution.";
RL Nat. Genet. 45:487-494(2013).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; CM007657; ONH97316.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251NDE3; -.
DR EnsemblPlants; ONH97316; ONH97316; PRUPE_7G183500.
DR Gramene; ONH97316; ONH97316; PRUPE_7G183500.
DR Proteomes; UP000006882; Chromosome g7.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF47; DNA MISMATCH REPAIR PROTEIN MLH3; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000006882}.
FT DOMAIN 182..326
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 976..1136
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 1213 AA; 136632 MW; 41EF758C3C29E873 CRC64;
MMRGVKPLPE AARSSMRSGV ILYDLTSVVE ELVFNSLDAG ATKVSVFIGV GTCYVKVVDD
GFGITRDGLV LVGERYATSK FDHSPGTDSA SGSFGFRGEA LASISDLSLL EILTKASGRP
NGYRKVMKGC KCLYLGIDDD RKDVGTTVVV RDLFYNQPVR RKYMQSSPKK VLHAVVKCVH
RIALVHSKVS FKLIDIESED ELLRTISSPS PVALLKRTVG IDVSTALHEL NISDDINSRF
ICKGPIHKLL NQLASNSECW DPGKDVDVSQ NRKRSRPQSL PAYFLNLSCP RSFYDLTFEP
SKTYVEFKDW VPVLTFIDKA IQNFWKEKIT DGESGCHGAD MVGEDQMWKK DLLDGDLSEL
SKFGKKRSRL QNCQASPDLM EMLIKEDNHT SQKRHVRTSY GYLHENTKDF DDFQKQHIEI
EFGHHTDYSF QSRDDHLAKV MLTATPKKEK HPSMPDINFF PEEDYIMEYR SAAAEGSSNV
DDNIFSSSWQ DEPFKLDPSV GNGSTGSGVS CGLNEFGTDA EFTHDLVQPF LRSCSSKGRF
PSERDLCTDG GLKFHYDGFR NKRRRGGFYN SVESPEIDGS KSCDFVSRTL WPEEESSVQP
FPSVITKFDL YTEFDSPSRD FIKSIPRYGE HFGGENSFMN AENVVSCHKT LINDLCSVTS
NSLSQSTYLD FEPFSNINAV EGHYRSVKRD TNKYFVDGEE KDCTFSYDII SKSSSREHCN
THTDRELEFN DYAGSRKFFQ PHNLDGEFSP EGPDILADET DWSRQYSHCN DNMGIDMYKR
QKDQFEDQDC LKNHVSIGRS KRSHSAPPFY RCKRRYFTLS HPLTTRAGKL DAQNFHNAAT
YPEASKMKDL HQPPDGCHLN LKLSAVEDIS ADDRYQESQD FKAGVNKHEV EMFEQSKCSG
IQATAPIKEF ISTDQDSLNC GTKWRNCCPQ IMNASKMQGL HDQNSILDIS SGFLHLAADS
LVPESITKNC LSDCRVLQQV DKKYIAVMAG RTLAIIDQHA ADERIRLEEL RQKVLSGEAK
TITFLDVEQE LVLPEIGYQL LHNYAKPVEE WGWLCNIQAE GSGSFKRNLN LLHRQPTAIT
LIAVPCILGV NLSDSDLMEF LQQLADTDGS STMPPSVLRI LNSKACRGAI MFGDSLLHSE
CSLIVEELKQ TSLCFQCAHG RPTTAPLVNL EALRKHIAKM ASLSDGEDQL WHGLRRHELS
LERAEKRLSL SKS
//
