ID A0A251NI94_PRUPE Unreviewed; 1962 AA.
AC A0A251NI94;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
GN ORFNames=PRUPE_6G003600 {ECO:0000313|EMBL:ONH98991.1};
OS Prunus persica (Peach) (Amygdalus persica).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX NCBI_TaxID=3760 {ECO:0000313|EMBL:ONH98991.1, ECO:0000313|Proteomes:UP000006882};
RN [1] {ECO:0000313|EMBL:ONH98991.1, ECO:0000313|Proteomes:UP000006882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nemared {ECO:0000313|Proteomes:UP000006882};
RX PubMed=23525075; DOI=10.1038/ng.2586;
RA Verde I., Abbott A.G., Scalabrin S., Jung S., Shu S., Marroni F.,
RA Zhebentyayeva T., Dettori M.T., Grimwood J., Cattonaro F., Zuccolo A.,
RA Rossini L., Jenkins J., Vendramin E., Meisel L.A., Decroocq V.,
RA Sosinski B., Prochnik S., Mitros T., Policriti A., Cipriani G., Dondini L.,
RA Ficklin S., Goodstein D.M., Xuan P., Del Fabbro C., Aramini V., Copetti D.,
RA Gonzalez S., Horner D.S., Falchi R., Lucas S., Mica E., Maldonado J.,
RA Lazzari B., Bielenberg D., Pirona R., Miculan M., Barakat A., Testolin R.,
RA Stella A., Tartarini S., Tonutti P., Arus P., Orellana A., Wells C.,
RA Main D., Vizzotto G., Silva H., Salamini F., Schmutz J., Morgante M.,
RA Rokhsar D.S.;
RT "The high-quality draft genome of peach (Prunus persica) identifies unique
RT patterns of genetic diversity, domestication and genome evolution.";
RL Nat. Genet. 45:487-494(2013).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
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DR EMBL; CM007656; ONH98991.1; -; Genomic_DNA.
DR EnsemblPlants; ONH98991; ONH98991; PRUPE_6G003600.
DR Gramene; ONH98991; ONH98991; PRUPE_6G003600.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000006882; Chromosome g6.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000006882};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 2..337
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 1151..1387
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1549..1645
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 385..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1082..1103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1403..1464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1403..1418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1444..1461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1962 AA; 212642 MW; F07EC2FA39E30697 CRC64;
MWTNVFKIGG LHQISWFQFL PHDSELIPQP DKSSVKDAAT QLVLSSHLQL QKEGFLSTWT
NSFVGPWDPS QGLHNPDEKI KLWLFLPGRH SSYADPAQAA VSKLRVVASG LWMSPGDSEE
VATALSQALR NRIERALSGL AYMRFGDVFS KFHASQSEEL LRRGQPTVEF IFAATEEGIF
VHALVSAKHI RALSSDDLER VQKHSSQNSC YGLPVIVSPH GICGRLTGCC PGDLVKQVYF
SSSKLKTSNF IGLPNHVSQG SGSQLTWQNC YVEVTLGCPR PRSDRALQSN SNSFRNVVKH
HPVESPSLGR GDQKGSLDNI SVYEKTFVYP AEAVLVPSLQ VAGSSLKRFW LQNWIGPSMP
GSSFFMLCSD SIEPMEECNE TNGIRTQRGY NSSSNSNSSS ISSISSSSSD SDDKMATGAS
ELEADADSLT CRQSGLSFNN RLGNDISKLG FKRPRDGMAE SFAEVGTATS ASLQDTYNSD
FGSMEVNNSA ITVVTNDQIG SLWDWDGDDR YGTDIHALIN EFGDFGDLFE SDVLPFGEPP
GTTESQALMF SAPDFGDVVD NPVGVMDVSD QLLLSEGFAS FESFIPPPPA AMEETLIKNQ
EAINSALSSG PVNCSSASNI SEFDHIIKAE ALMTFAPEYG AVETPTSEVS SSIFRSPYLP
KSRKAESSNS SPSIYTYGPT PPSSCFDGFD EKTGIPSNSK PFAGKKDASN IFRSKNYYTH
VESGKEQQDR RLLTSSNGIV VAHDGVAQSP FPVLNSTNAV KAAQRKMTEG TFESENSFLS
MRTIPATEIE CILFQASMCR IRHTLLSSSS LSSIGFSRLP GDQTVMPENI SGKYEARRKE
SIPVRIAGDI DGGMIDGHLN APVGVWRSVG APRVPKPTSS SSMEISSSLP HTSFNDESML
SYGRQPLQEL LDGLSLLVQQ ATSFVDLALD SDCSDGPYGW LALQEQWRKG FSCGPSMVHA
GCGGTLASCH SLDIAGVELV DPLSADVHAS SVISLLQSDI KTALKSAFGI LDGPLPVTDW
CRGRNQSGES TVDGYSAEST ISECKDSSSI VAPSIIEPLS PSPSCSAGST CLKVSSAMDG
AKVDETSQRR SNQENCTSES DLQMSSRLRP TLFVIPLPAI LVGYQDDWLK TSASSLQLWE
KAPLEPYALQ KPITYYVVCP DIDPLTSAAA DFFQQLGTVY ETCKLGTHLP QSFGSQMEVD
SGRRPSSGFV LLDCPQAMKI ESRNASLVGS LSDYFLSISN GWDLTSYLKS LSKALKALKL
GHCLSTNAKE GSSGPSTVIY VVCPFPEPIA ILQTVIESSV AIGSVIFQSD RERRSILYSQ
VSKALSYSAT VDEASISNIL VLSGFGIPKL VLQIVTVDAI FKVTSPSLNE LVILKETAFT
VYNKARRISR GASSDAVQSS LSSRSHTVLS QMSSPTPGTW KDCGGPRITG HSLPREGEMD
ASLRTGSWDS SWQTTRTGAA NCDPNRIGDF FSQDETRYMF EPLFILAEPG SLERAFSPLA
FGNLPSEPSK ALSDDISGGF MQSTSLGGSA DSGSGSQADG SELDKIPPSL HCCYGWTEDW
RWLICIWTDS RGELLDSHIF PFGGISSRQD TKGLECLFVQ VLQQGCQILQ ACSSDTGVAK
PRDFVIARIG SFYELEYQEW QKAINSVGGS EVKKWHLQLR RSVSDGVSAS SNGPSLQQQE
MSLIQERTLP SSPGPLYGSS HSKISGFMKG GLGQPSVRKQ LMGTQLIDSS RSLLQWVQSI
SFITIAIDHS LHLVFPADTQ SPGAQGGVGV GSSGYLEGFT PVKSLGSTPA AYILIPSPSM
RFLPPTPLQL PTCLTAESPP LAHLLHSKGS AIPLSTCFVV SKAVPTMRRD YRSNLKEEWP
STLLVSLIDH YGGNNFSQEK LMRGNTKQVG RSPSSEAREL EIETHVILES LAAELHALSW
MTVSPAYLER RTALPFHCDM VLRLRRLLHF ADKDLSRHQE KP
//
