ID A0A251NV32_PRUPE Unreviewed; 793 AA.
AC A0A251NV32;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=Minichromosome maintenance 8 {ECO:0000256|ARBA:ARBA00042306};
GN ORFNames=PRUPE_6G241500 {ECO:0000313|EMBL:ONI03147.1};
OS Prunus persica (Peach) (Amygdalus persica).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX NCBI_TaxID=3760 {ECO:0000313|EMBL:ONI03147.1, ECO:0000313|Proteomes:UP000006882};
RN [1] {ECO:0000313|EMBL:ONI03147.1, ECO:0000313|Proteomes:UP000006882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nemared {ECO:0000313|Proteomes:UP000006882};
RX PubMed=23525075; DOI=10.1038/ng.2586;
RA Verde I., Abbott A.G., Scalabrin S., Jung S., Shu S., Marroni F.,
RA Zhebentyayeva T., Dettori M.T., Grimwood J., Cattonaro F., Zuccolo A.,
RA Rossini L., Jenkins J., Vendramin E., Meisel L.A., Decroocq V.,
RA Sosinski B., Prochnik S., Mitros T., Policriti A., Cipriani G., Dondini L.,
RA Ficklin S., Goodstein D.M., Xuan P., Del Fabbro C., Aramini V., Copetti D.,
RA Gonzalez S., Horner D.S., Falchi R., Lucas S., Mica E., Maldonado J.,
RA Lazzari B., Bielenberg D., Pirona R., Miculan M., Barakat A., Testolin R.,
RA Stella A., Tartarini S., Tonutti P., Arus P., Orellana A., Wells C.,
RA Main D., Vizzotto G., Silva H., Salamini F., Schmutz J., Morgante M.,
RA Rokhsar D.S.;
RT "The high-quality draft genome of peach (Prunus persica) identifies unique
RT patterns of genetic diversity, domestication and genome evolution.";
RL Nat. Genet. 45:487-494(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
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DR EMBL; CM007656; ONI03147.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251NV32; -.
DR STRING; 3760.A0A251NV32; -.
DR EnsemblPlants; ONI03147; ONI03147; PRUPE_6G241500.
DR Gramene; ONI03147; ONI03147; PRUPE_6G241500.
DR eggNOG; KOG0480; Eukaryota.
DR OrthoDB; 147095at2759; -.
DR Proteomes; UP000006882; Chromosome g6.
DR GO; GO:0042555; C:MCM complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:EnsemblPlants.
DR GO; GO:0007143; P:female meiotic nuclear division; IEA:EnsemblPlants.
DR GO; GO:0007140; P:male meiotic nuclear division; IEA:EnsemblPlants.
DR GO; GO:0009555; P:pollen development; IEA:EnsemblPlants.
DR CDD; cd17759; MCM8; 1.
DR CDD; cd22247; MCM8_WHD; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF47; DNA HELICASE MCM8; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006882}.
FT DOMAIN 344..551
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
SQ SEQUENCE 793 AA; 87290 MW; 1D30F8E728CD66E2 CRC64;
MYGAPGRSSS SNNGSLCAPG FFSIWSTYLA QIELGDDKPW LNLTHSLIGF FSTTLGQVLL
SQLKDDGGVS VLSIDFEKFR KMCDVEDLYV ALEEKPKITL LCMSVAAHQV LLTQWDNNRV
EEGIKVNIRL HNYPESMIAL KNLKAAYIDK LVSVRGTVVK VSTVKPLVVQ MGFDCVKCKT
SITRMFPDGK FSPPSKCDLD GCKSRNFNPI RSTAQTIDFQ KIRIQELLKP EDHEDGRVPR
TVECELLEDL VDACIPGDVV TVTGIIRVIN NYMDIGGGKS KGKSQGIYYL YLEAVSIKNS
KSQSTPEDVQ DSNSNDMALV DFCSFSPRDL EFIVKFSEEH GPDTFRQLLQ SICPSIYGHE
LVKAGIILAL FGGVRKHSND QNKVPVRGDI HVIIVGDPGL GKSQLLQAAA AVSPRGIYVC
GNATTRAGLT VAVVKDPMTS DYAFEAGAMV LADSGLCCID EFDKMTTEHQ ALLEAMEQQC
VSIAKAGLVA SLSARTSVLA AANPVGGHYN RAKTVNENLK IGAALLSRFD LVFILLDKPN
ELLDKRVSEH IMSLHAGYGE HSPAAKRIRG ASQSAEGIDM NGEGGSLVSR LRLDPNTDGD
FVPLPVQLLR KYIAYARNYV FPRMSKPAAE ILQKFYLKLR DHATSADSTP ITARQLESLV
RLTQARARLD LREEITAQDA TDVVEIMRES LYDKYIDEHG VVDFGRSGGM SQQKEAKRFL
SALNRQSELQ QKDCFTISEI YSLADRIGLR VPDIDTFVDN LNSVGYLLKK GAKTYQVLSS
SYSRSQSSSR SRG
//
