ID A0A251P1M9_PRUPE Unreviewed; 1277 AA.
AC A0A251P1M9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=PRUPE_5G011100 {ECO:0000313|EMBL:ONI05518.1};
OS Prunus persica (Peach) (Amygdalus persica).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX NCBI_TaxID=3760 {ECO:0000313|EMBL:ONI05518.1, ECO:0000313|Proteomes:UP000006882};
RN [1] {ECO:0000313|EMBL:ONI05518.1, ECO:0000313|Proteomes:UP000006882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nemared {ECO:0000313|Proteomes:UP000006882};
RX PubMed=23525075; DOI=10.1038/ng.2586;
RA Verde I., Abbott A.G., Scalabrin S., Jung S., Shu S., Marroni F.,
RA Zhebentyayeva T., Dettori M.T., Grimwood J., Cattonaro F., Zuccolo A.,
RA Rossini L., Jenkins J., Vendramin E., Meisel L.A., Decroocq V.,
RA Sosinski B., Prochnik S., Mitros T., Policriti A., Cipriani G., Dondini L.,
RA Ficklin S., Goodstein D.M., Xuan P., Del Fabbro C., Aramini V., Copetti D.,
RA Gonzalez S., Horner D.S., Falchi R., Lucas S., Mica E., Maldonado J.,
RA Lazzari B., Bielenberg D., Pirona R., Miculan M., Barakat A., Testolin R.,
RA Stella A., Tartarini S., Tonutti P., Arus P., Orellana A., Wells C.,
RA Main D., Vizzotto G., Silva H., Salamini F., Schmutz J., Morgante M.,
RA Rokhsar D.S.;
RT "The high-quality draft genome of peach (Prunus persica) identifies unique
RT patterns of genetic diversity, domestication and genome evolution.";
RL Nat. Genet. 45:487-494(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; CM007655; ONI05518.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251P1M9; -.
DR EnsemblPlants; ONI05518; ONI05518; PRUPE_5G011100.
DR Gramene; ONI05518; ONI05518; PRUPE_5G011100.
DR Proteomes; UP000006882; Chromosome g5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006882};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1277
FT /note="SSD domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012784022"
FT TRANSMEM 284..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 688..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 733..755
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 835..858
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1115..1135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1142..1161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1167..1185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1206..1227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1239..1263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 624..787
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1277 AA; 140288 MW; 9EFD810A52CCB64B CRC64;
MCAANYVAKT SVNLTVVLCF LSLAYAQTSV TTNATAGERH SEEYCAMYGI CGKRSDGKYL
NCPFGSPSVK PDDLLSSKVQ SLCPTITGNV CCTETQFDTL RSQVQQAIPF LVGCPACLRN
FLNLFCELTC SPSQSLFINV TSVAKVNNNL TVDGIDFYIT DAYGEGLYDS CKDVKFGTMN
SRAMEFIGAG AKNFKEWFTF IGRQAPSNVP GSPYAIRFSS SVTESSAMKP MNVSTYSCGD
NSLGCSCGDC PSSTVCSNTV SPVSQKGGSC SVRIGSVKAK CIDLAVAILY IVLVSVFFGW
GLFRRTRKAN PASMTNPWWN VMDDSEVHSI SREKNENPPM QVFEDAPHIR NSVQLSIVQG
YMSRFFRRYG TWVARNPVIV LCSSLALVLL LCLGLIRFKV ETRPEKLWVG PGSKAAEEKN
FFDSHLAPFY RIEQLILATI PEVKHGSSPS IVTEENIKLL FEIQKKVDGI KANYSGSVIS
LADICMKPMD KDCATQSVLQ YFKMNPANYD DYGGVEHLKY CFEHYSSADK CMSAFKGPLD
PSTALGGFSG KNYSEATAFL VTYPVNNAIS KEENETERAV TWEKAFIKLA KDELLQMVQS
RNLTLSFSSE SSVEEELKRE SSADAITILI SYLVMFAYIS LTLGDSPRLS SFYISSKVLL
GLSGVVLVML SVLGSVGFFS LIGVKSTLII MEVIPFLVLA VGVDNMCILV NAVKRQPLEL
SLEGRISNAL VEVGPSITLA SLSEVLAFAV GSFIPMPACR VFSMFAALAV LLDFLLQVTA
FVALIVFDFR RTEDKRVDCF PCMKISSYTN SDKGIDQRKP GLLTRYMKEI HAPILSLWGV
KIAVICVFVA FALASIALCT RIQPGLEQKI VLPRDSYLQG YFNNVSEYLR IGPPLYFVVK
NYNYSSESRH TNQLCSISQC DSDSLLNEIA RASLTPESSY IAKPAASWLD DFLVWISPEA
FGCCRKFTNG AYCPPDDQPP CCSSSDGSCS LGGVCKDCTT CFRHSDLRNG RPSTTQFKEK
LPWFLSALPS SDCAKGGHGA YTSSVEFKGN GSDIIPASSF RTYHTPLNKQ VDYVNSMRAA
RELSSRLSDS LNIEIFPYSV FYMFFEQYLD IWRTALINLS IAIGAVFIVC LAITCSLWSS
SIILLVLAMI VVDLMGVMAI LNIQLNAVSV VNLVMAVGIS VEFCVHMTHA FSVSTGDKDQ
RTKEALATMG ASVFSGITLT KLVGVIVLCF SRTEVFVVYY FQMYLALVLL GFLHGLVFLP
VVLSMFGPPS RRVLIEE
//
