ID A0A251P8D5_PRUPE Unreviewed; 990 AA.
AC A0A251P8D5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN ORFNames=PRUPE_5G142600 {ECO:0000313|EMBL:ONI07847.1};
OS Prunus persica (Peach) (Amygdalus persica).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX NCBI_TaxID=3760 {ECO:0000313|EMBL:ONI07847.1, ECO:0000313|Proteomes:UP000006882};
RN [1] {ECO:0000313|EMBL:ONI07847.1, ECO:0000313|Proteomes:UP000006882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nemared {ECO:0000313|Proteomes:UP000006882};
RX PubMed=23525075; DOI=10.1038/ng.2586;
RA Verde I., Abbott A.G., Scalabrin S., Jung S., Shu S., Marroni F.,
RA Zhebentyayeva T., Dettori M.T., Grimwood J., Cattonaro F., Zuccolo A.,
RA Rossini L., Jenkins J., Vendramin E., Meisel L.A., Decroocq V.,
RA Sosinski B., Prochnik S., Mitros T., Policriti A., Cipriani G., Dondini L.,
RA Ficklin S., Goodstein D.M., Xuan P., Del Fabbro C., Aramini V., Copetti D.,
RA Gonzalez S., Horner D.S., Falchi R., Lucas S., Mica E., Maldonado J.,
RA Lazzari B., Bielenberg D., Pirona R., Miculan M., Barakat A., Testolin R.,
RA Stella A., Tartarini S., Tonutti P., Arus P., Orellana A., Wells C.,
RA Main D., Vizzotto G., Silva H., Salamini F., Schmutz J., Morgante M.,
RA Rokhsar D.S.;
RT "The high-quality draft genome of peach (Prunus persica) identifies unique
RT patterns of genetic diversity, domestication and genome evolution.";
RL Nat. Genet. 45:487-494(2013).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR EMBL; CM007655; ONI07847.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251P8D5; -.
DR EnsemblPlants; ONI07847; ONI07847; PRUPE_5G142600.
DR Gramene; ONI07847; ONI07847; PRUPE_5G142600.
DR Proteomes; UP000006882; Chromosome g5.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10810; GH38N_AMII_LAM_like; 1.
DR Gene3D; 2.60.40.1360; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 2.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR048534; Man2a1-like_dom.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF3; LYSOSOMAL ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR Pfam; PF21260; Laman-like_dom; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000006882};
KW Signal {ECO:0000256|RuleBase:RU361199};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT CHAIN 22..990
FT /note="Alpha-mannosidase"
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT /id="PRO_5017854941"
FT DOMAIN 355..429
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 990 AA; 111836 MW; 41CA571D68981EF0 CRC64;
MALEACFRLL LLLLLFLIAE PKYVQYNTTS RLVPGKLNVH LVPHTHDDVG WLKTVDQYYV
GSNNSIQGAC VQNVLDSLVP ALLADKNRKF IYVEQAFFQR WWREQSEGTQ NTVRRLVNNG
QLELINGGMC MHDEAAPHYI DMIDQTTLGH QFIKEEFNMT PRIGWQIDPF GHSAVQAYLL
GAEAGFDSLF FARIDYQDRE KRKNEKSLEV VWRGSKSLGS SAQIFAGAFP KNYEPPTDNF
YFEVNDESPI VQDDMDLFDY NVPDRVNEFV SAAISQANIT RTNHIMWTMG TDFKYQYANS
WFRQMDKFIH YVNQDGRVNA LYSTPSIYTD AKYAANESWP IKSDDFFPYA DKVNAYWTGY
FTSRPAIKGY VRALSGYYLA ARQLEFFKGM SKSRPNTDSL ADALAIAQHH DAVSGTEKQH
VADDYAKRLS IGYNEAEKVV AESLACMTES RSEAGCKSPS TKFQQCPLLN ISYCPPSEAD
LSNGKSLVIV VYNSLGWKRE DIIKIPVVSA NVTVRDFTGK EIESQLLPLL NASVGIRNDH
VRAYLGISPS VTPSYWLTFS ATVPPLGFST YIVSSATQTA TSSARRTVYK SEASQNDTIE
VGPGNLKLIY SGNKGKLTQY FNSRSSVKES IEQSFSYYAG DDGSVDKQAD GAYIFRPNGT
YPIQSEGQVT RVYKEKEHAE IEFTVGPIPI GDGIGKEIVT KITTSMETNK TFYTDSNGRD
FIERIRDYRK DWDLQVNQPV AGNYYPINLG IYAKDNNTEM SVLVDRSVGG SSIVDGQLEL
MVHRRLLHDD DRGVEEPLNE TVCIQDICKG LTITGKYYLR LDPLGEGAKW RRSFGQEIYS
PFLLAFTEQE GDNWTSSHVT TFSWMDPSYV LPDNVAIITL QELEDGKLLF RLAHLYEIEE
DKDLSVMASV ELKKVFADKK INKVAEMSLS ANQERAEMEK KRLTWKVEGS SEEEDAAKVM
RGGPVDPTKL VVDVAPMEIR TFIIDFYSKH
//
