ID A0A251PRW7_PRUPE Unreviewed; 141 AA.
AC A0A251PRW7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Gamma-secretase subunit PEN-2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=PRUPE_4G271100 {ECO:0000313|EMBL:ONI14252.1};
OS Prunus persica (Peach) (Amygdalus persica).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX NCBI_TaxID=3760 {ECO:0000313|EMBL:ONI14252.1, ECO:0000313|Proteomes:UP000006882};
RN [1] {ECO:0000313|EMBL:ONI14252.1, ECO:0000313|Proteomes:UP000006882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nemared {ECO:0000313|Proteomes:UP000006882};
RX PubMed=23525075; DOI=10.1038/ng.2586;
RA Verde I., Abbott A.G., Scalabrin S., Jung S., Shu S., Marroni F.,
RA Zhebentyayeva T., Dettori M.T., Grimwood J., Cattonaro F., Zuccolo A.,
RA Rossini L., Jenkins J., Vendramin E., Meisel L.A., Decroocq V.,
RA Sosinski B., Prochnik S., Mitros T., Policriti A., Cipriani G., Dondini L.,
RA Ficklin S., Goodstein D.M., Xuan P., Del Fabbro C., Aramini V., Copetti D.,
RA Gonzalez S., Horner D.S., Falchi R., Lucas S., Mica E., Maldonado J.,
RA Lazzari B., Bielenberg D., Pirona R., Miculan M., Barakat A., Testolin R.,
RA Stella A., Tartarini S., Tonutti P., Arus P., Orellana A., Wells C.,
RA Main D., Vizzotto G., Silva H., Salamini F., Schmutz J., Morgante M.,
RA Rokhsar D.S.;
RT "The high-quality draft genome of peach (Prunus persica) identifies unique
RT patterns of genetic diversity, domestication and genome evolution.";
RL Nat. Genet. 45:487-494(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PEN-2 family.
CC {ECO:0000256|ARBA:ARBA00009607}.
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DR EMBL; CM007654; ONI14252.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251PRW7; -.
DR STRING; 3760.A0A251PRW7; -.
DR EnsemblPlants; ONI14252; ONI14252; PRUPE_4G271100.
DR Gramene; ONI14252; ONI14252; PRUPE_4G271100.
DR eggNOG; KOG3402; Eukaryota.
DR OrthoDB; 1219119at2759; -.
DR Proteomes; UP000006882; Chromosome g4.
DR GO; GO:0070765; C:gamma-secretase complex; IBA:GO_Central.
DR GO; GO:0005798; C:Golgi-associated vesicle; IEA:EnsemblPlants.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR019379; Gamma_Secretase_Asp_P_PEN2.
DR PANTHER; PTHR16318; GAMMA-SECRETASE SUBUNIT PEN-2; 1.
DR PANTHER; PTHR16318:SF0; GAMMA-SECRETASE SUBUNIT PEN-2; 1.
DR Pfam; PF10251; PEN-2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000006882};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 141 AA; 15993 MW; 6972239230D28AF8 CRC64;
MEASLGNGEM PNQNPINPRS NVTLVPSSSS PVWPTIDGPL GLSEEDSVSY ARRFYKFGFA
LLPWLWALNC FYFWPALRHS RSFPRIHHYV LRSAVGLTVF TVLLASWAFT FVIGGERLFG
HVWDQLVMYN LADRLGLTGW S
//
