ID A0A251R3M8_PRUPE Unreviewed; 901 AA.
AC A0A251R3M8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775};
DE EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775};
GN ORFNames=PRUPE_1G265900 {ECO:0000313|EMBL:ONI30671.1};
OS Prunus persica (Peach) (Amygdalus persica).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX NCBI_TaxID=3760 {ECO:0000313|EMBL:ONI30671.1, ECO:0000313|Proteomes:UP000006882};
RN [1] {ECO:0000313|EMBL:ONI30671.1, ECO:0000313|Proteomes:UP000006882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nemared {ECO:0000313|Proteomes:UP000006882};
RX PubMed=23525075; DOI=10.1038/ng.2586;
RA Verde I., Abbott A.G., Scalabrin S., Jung S., Shu S., Marroni F.,
RA Zhebentyayeva T., Dettori M.T., Grimwood J., Cattonaro F., Zuccolo A.,
RA Rossini L., Jenkins J., Vendramin E., Meisel L.A., Decroocq V.,
RA Sosinski B., Prochnik S., Mitros T., Policriti A., Cipriani G., Dondini L.,
RA Ficklin S., Goodstein D.M., Xuan P., Del Fabbro C., Aramini V., Copetti D.,
RA Gonzalez S., Horner D.S., Falchi R., Lucas S., Mica E., Maldonado J.,
RA Lazzari B., Bielenberg D., Pirona R., Miculan M., Barakat A., Testolin R.,
RA Stella A., Tartarini S., Tonutti P., Arus P., Orellana A., Wells C.,
RA Main D., Vizzotto G., Silva H., Salamini F., Schmutz J., Morgante M.,
RA Rokhsar D.S.;
RT "The high-quality draft genome of peach (Prunus persica) identifies unique
RT patterns of genetic diversity, domestication and genome evolution.";
RL Nat. Genet. 45:487-494(2013).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR EMBL; CM007651; ONI30671.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251R3M8; -.
DR STRING; 3760.A0A251R3M8; -.
DR EnsemblPlants; ONI30671; ONI30671; PRUPE_1G265900.
DR Gramene; ONI30671; ONI30671; PRUPE_1G265900.
DR eggNOG; KOG1096; Eukaryota.
DR OrthoDB; 20951at2759; -.
DR UniPathway; UPA00591; UER00663.
DR Proteomes; UP000006882; Chromosome g1.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003876; F:AMP deaminase activity; IBA:GO_Central.
DR GO; GO:0046033; P:AMP metabolic process; IBA:GO_Central.
DR GO; GO:0006188; P:IMP biosynthetic process; IBA:GO_Central.
DR GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd01319; AMPD; 1.
DR Gene3D; 4.10.800.20; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR006650; A/AMP_deam_AS.
DR InterPro; IPR006329; AMPD.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01429; AMP_deaminase; 1.
DR PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR PANTHER; PTHR11359:SF14; AMP DEAMINASE; 1.
DR Pfam; PF19326; AMP_deaminase; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR PROSITE; PS00485; A_DEAMINASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006882};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 58..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..76
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 901 AA; 102980 MW; 4EF21403C0B0BCDC CRC64;
MDSSSSSSSA PSTSSLHLAM AAFVGASLMA VSAFYIHKRS VDQVLQRLIE IRRKPSRISD
NRSATEDGRE ESYIEDGEER GFESDGEVTD VAIDRNMRPR SVDDKALQSY RISSSLPNVA
SRSTDWMEEE AKFDPPPNFR PPRFSSSLDK LNFIPSGLPL LRTDQRTGEG QSGNHSGSNT
RMTPIGRLMT PRSQAGNAFE SIADSDEEGT EFANEDDDTF NYGNVDSLDN TVTSVYQNEV
LRKSDVKNFI QDRMYQVTST EAKSGVDLQG DGKVDTASGN SVKNDHNFTS IVLPLSASMH
ESISKEEEEV HKMIRECLDL RKRYLYREEV APWTVARTDS IASEKKSDPF HFEPVEASTH
CFRMEDGVIH VYASENDTVD IFPVASSTAF FTDMHYLLKV LSIGNVRSAC HHRLRFLEEK
FRVHLLLNAD REFLAQKSAP HRDFYNVRKV DTHVHHSACM NQKHLLSFIK SKLKKEPDEV
VIFRDGKYLT LKEVFESLDL TGHDLNVDLL DVHADKSTFH RFDKFNLKYN PCGQSRLREI
FLKQDNLIQG RFLAEVTKEV LSDLEASRYQ MAEYRISVYG RKQSEWDQLA SWFVNNSIYS
ENAVWLIQLP RLYNIYKKMG IVTSFQNILD NVFIPLFEAT VNPNSHPQLH LFLMQVVGFD
VVDDESKPER RPTKHMPTPA EWTNEFNPAY SYYAYYCYAN LYTLNKLRES KGLPTIKFRP
HCGEAGDIDH LAAGFLLCHN ISHGINLRKT PVLQYLYYLA QVGLLMSPLS NNSLFLDYHR
NPFPMFFQRG LNVSLSSDDP LQIHLTKEPL VEEYSVAAQV WKLSACDLCE VARNSVYQSG
FSHVAKSHWL GSKYFLRGPE GNDMQKTNVP HLRIAFRHET WKEEIQYIYA GKAKFPVETD
P
//
