ID A0A251RD06_PRUPE Unreviewed; 1031 AA.
AC A0A251RD06;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=ER membrane protein complex subunit 1 {ECO:0000256|ARBA:ARBA00020824};
GN ORFNames=PRUPE_1G450600 {ECO:0000313|EMBL:ONI33862.1};
OS Prunus persica (Peach) (Amygdalus persica).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX NCBI_TaxID=3760 {ECO:0000313|EMBL:ONI33862.1, ECO:0000313|Proteomes:UP000006882};
RN [1] {ECO:0000313|EMBL:ONI33862.1, ECO:0000313|Proteomes:UP000006882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nemared {ECO:0000313|Proteomes:UP000006882};
RX PubMed=23525075; DOI=10.1038/ng.2586;
RA Verde I., Abbott A.G., Scalabrin S., Jung S., Shu S., Marroni F.,
RA Zhebentyayeva T., Dettori M.T., Grimwood J., Cattonaro F., Zuccolo A.,
RA Rossini L., Jenkins J., Vendramin E., Meisel L.A., Decroocq V.,
RA Sosinski B., Prochnik S., Mitros T., Policriti A., Cipriani G., Dondini L.,
RA Ficklin S., Goodstein D.M., Xuan P., Del Fabbro C., Aramini V., Copetti D.,
RA Gonzalez S., Horner D.S., Falchi R., Lucas S., Mica E., Maldonado J.,
RA Lazzari B., Bielenberg D., Pirona R., Miculan M., Barakat A., Testolin R.,
RA Stella A., Tartarini S., Tonutti P., Arus P., Orellana A., Wells C.,
RA Main D., Vizzotto G., Silva H., Salamini F., Schmutz J., Morgante M.,
RA Rokhsar D.S.;
RT "The high-quality draft genome of peach (Prunus persica) identifies unique
RT patterns of genetic diversity, domestication and genome evolution.";
RL Nat. Genet. 45:487-494(2013).
CC -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC {ECO:0000256|ARBA:ARBA00011276}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the EMC1 family.
CC {ECO:0000256|ARBA:ARBA00007904}.
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DR EMBL; CM007651; ONI33862.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251RD06; -.
DR STRING; 3760.A0A251RD06; -.
DR EnsemblPlants; ONI33862; ONI33862; PRUPE_1G450600.
DR Gramene; ONI33862; ONI33862; PRUPE_1G450600.
DR eggNOG; KOG2103; Eukaryota.
DR Proteomes; UP000006882; Chromosome g1.
DR GO; GO:0072546; C:EMC complex; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR026895; EMC1.
DR InterPro; IPR011678; EMC1_C.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR21573:SF0; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1; 1.
DR PANTHER; PTHR21573; UNCHARACTERIZED; 1.
DR Pfam; PF07774; EMC1_C; 1.
DR Pfam; PF13360; PQQ_2; 1.
DR SMART; SM00564; PQQ; 4.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 2.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006882};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 998..1021
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 813..1030
FT /note="ER membrane protein complex subunit 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07774"
SQ SEQUENCE 1031 AA; 114683 MW; F2C121DA0BE2A756 CRC64;
MTLSLLAHFE VLTSYKNFHR SLRSITSFVV TATQREREGE RVTMGTTSMA SRVFLLLLIF
LSSTNLSLSL YEDQVGLMDW HQQYIGKVKG AVFHTQKSGR RRVVVSTEEN VIASLDLRHG
EIFWRHVLGS NDVIDGIDIA LGKYVITLSS GGGILRAWNL PDGQMVWESF LEGSGASKSL
LTVPTNLKVD KDNLILVFGK GSLHAISSID GEVLWKKEIA PESVEVQQII QPLGSDIIYV
LGFFGSSQFD AYKINARNGE LLKHNSATFS GGFSSEALVV SSEILVTLDS TRSKLVIISF
QDGEINYQQT HISDIFGDSL GTPVLLPSKL PGMFSVKIDG AVVFIRVTGE GKLEVLDKIN
NVAAISDAIS LSEGQQAFAL IQHGDGKIHL TVKPSHDLSG DLLKESIDMD NQRGTVHKIF
INNYIRTDRS HGFRALIVME DHSLLLLQQG AIVWSREDGL ASIVDVVTSE LPVEKEGVSV
AKVEQNLFEW LKGHILKLKG TLMLASAEDV AAIQEMRLKS FEKSKMTRDH NGFRKLLIVL
TRAGKLFALH TGYGQVVWSL LLPTLRRSET CEYPTGLNIY HWQVPHHHAL DENPSVLVVG
RCGKNSDAPG VLSIVDAYTG KEINSMAAIH SVAQVIPLPF TDSTEQRLHL LIDVNQHGHL
YPRTSEAIDI FQRELTNIYW YSVEADNGII KGHVLKSNCI QEVIDNYCFE SKDIWSIVFP
SDSERIIATV IRKLSEVVHT QAKAIADEDV MFKYISKNLL FVATVAPKGS GPIGTATPEE
SWLTVYLIDT VTGRILHRMT HHGSQGPVHA VFSENWVVYH YFNLRAHRYE MSVIEIYDQS
RADNKDVWKL VLGKHNLTSP ISSYSRPEVV TKSQSYFFTY SVKALAVTLT AKGITSKQVL
IGTIGDQVLA LDKRFLDPRR SVNPTTAEKE EGIIPLTDSL PIIPQSYVTH ALKVEGLRGI
VTVPAKLEST TLAFAYGVDL FFTQLAPSRT YDSLTDDFSY ALLLITIVAL IAAIFVTWIL
SEKKELREKW R
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