ID A0A251RLJ2_HELAN Unreviewed; 599 AA.
AC A0A251RLJ2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=5-amino-6-(5-phosphoribosylamino)uracil reductase {ECO:0000256|ARBA:ARBA00013173};
DE EC=1.1.1.193 {ECO:0000256|ARBA:ARBA00013173};
GN ORFNames=HannXRQ_Chr17g0538711 {ECO:0000313|EMBL:OTF85323.1},
GN HanXRQr2_Chr17g0785731 {ECO:0000313|EMBL:KAF5753940.1};
OS Helianthus annuus (Common sunflower).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae;
OC Heliantheae alliance; Heliantheae; Helianthus.
OX NCBI_TaxID=4232 {ECO:0000313|EMBL:OTF85323.1, ECO:0000313|Proteomes:UP000215914};
RN [1] {ECO:0000313|EMBL:KAF5753940.1, ECO:0000313|Proteomes:UP000215914}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. SF193 {ECO:0000313|Proteomes:UP000215914};
RC TISSUE=Leaves {ECO:0000313|EMBL:KAF5753940.1};
RX PubMed=28538728; DOI=10.1038/nature22380;
RA Badouin H., Gouzy J., Grassa C.J., Murat F., Staton S.E., Cottret L.,
RA Lelandais-Briere C., Owens G.L., Carrere S., Mayjonade B., Legrand L.,
RA Gill N., Kane N.C., Bowers J.E., Hubner S., Bellec A., Berard A.,
RA Berges H., Blanchet N., Boniface M.C., Brunel D., Catrice O., Chaidir N.,
RA Claudel C., Donnadieu C., Faraut T., Fievet G., Helmstetter N., King M.,
RA Knapp S.J., Lai Z., Le Paslier M.C., Lippi Y., Lorenzon L., Mandel J.R.,
RA Marage G., Marchand G., Marquand E., Bret-Mestries E., Morien E.,
RA Nambeesan S., Nguyen T., Pegot-Espagnet P., Pouilly N., Raftis F.,
RA Sallet E., Schiex T., Thomas J., Vandecasteele C., Vares D., Vear F.,
RA Vautrin S., Crespi M., Mangin B., Burke J.M., Salse J., Munos S.,
RA Vincourt P., Rieseberg L.H., Langlade N.B.;
RT "The sunflower genome provides insights into oil metabolism, flowering and
RT Asterid evolution.";
RL Nature 546:148-152(2017).
RN [2] {ECO:0000313|EMBL:OTF85323.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Leaves {ECO:0000313|EMBL:OTF85323.1};
RA Langlade N., Munos S.;
RT "Sunflower complete genome.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF5753940.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:KAF5753940.1};
RA Gouzy J., Langlade N., Munos S.;
RT "Helianthus annuus Genome sequencing and assembly Release 2.";
RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-
CC ribitylamino)uracil from GTP: step 3/4.
CC {ECO:0000256|ARBA:ARBA00004910}.
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DR EMBL; MNCJ02000332; KAF5753940.1; -; Genomic_DNA.
DR EMBL; CM007906; OTF85323.1; -; Genomic_DNA.
DR STRING; 4232.A0A251RLJ2; -.
DR EnsemblPlants; mRNA:HanXRQr2_Chr17g0785731; mRNA:HanXRQr2_Chr17g0785731; HanXRQr2_Chr17g0785731.
DR Gramene; mRNA:HanXRQr2_Chr17g0785731; mRNA:HanXRQr2_Chr17g0785731; HanXRQr2_Chr17g0785731.
DR InParanoid; A0A251RLJ2; -.
DR OMA; RTGACTD; -.
DR OrthoDB; 1202710at2759; -.
DR UniPathway; UPA00275; UER00402.
DR Proteomes; UP000215914; Chromosome 17.
DR GO; GO:0008703; F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0008835; F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity; IBA:GO_Central.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd15457; NADAR; 1.
DR CDD; cd01284; Riboflavin_deaminase-reductase; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR Gene3D; 1.10.357.40; YbiA-like; 1.
DR InterPro; IPR002125; CMP_dCMP_dom.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR004794; Eubact_RibD.
DR InterPro; IPR012816; NADAR.
DR InterPro; IPR011549; RibD_C.
DR InterPro; IPR002734; RibDG_C.
DR InterPro; IPR037238; YbiA-like_sf.
DR NCBIfam; TIGR00326; eubact_ribD; 1.
DR NCBIfam; TIGR00227; ribD_Cterm; 1.
DR NCBIfam; TIGR02464; ribofla_fusion; 1.
DR PANTHER; PTHR38011:SF7; 2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE; 1.
DR PANTHER; PTHR38011; DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820); 1.
DR Pfam; PF00383; dCMP_cyt_deam_1; 1.
DR Pfam; PF08719; NADAR; 1.
DR Pfam; PF01872; RibD_C; 1.
DR SUPFAM; SSF53927; Cytidine deaminase-like; 1.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR SUPFAM; SSF143990; YbiA-like; 1.
DR PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000215914}.
FT DOMAIN 29..153
FT /note="CMP/dCMP-type deaminase"
FT /evidence="ECO:0000259|PROSITE:PS51747"
SQ SEQUENCE 599 AA; 65797 MW; 83354577845BC2E8 CRC64;
MAIPMRFATP IKCYTSPTIF NSTNDHHHAL DASYIQRAAE LSDKSACFTA PHPNFGCVIA
TTTTSGKVFG EGYLYAEGAK PAEVQAVEAA GEYCRGATAY VNMEPGDCHG DYTAVSALIK
AGISRVVIGM RHPLQHLRGK AIHTLKNEGL QVDVLGEDIR SGSIEDALKA CRVVNAPLLY
RSASQVPFSV LKYAMTLDGK IAASSGHASW ISSKKSRSRV FELRGRSDAV IVGGNTVRKD
NPRLTPRHGG GHLPTRIVMS QTLDLPEVAN LWDVREVPTI VATQRGARRS FQKLLASKGV
EVVEFDILNP KDVVNYLFDR GYLSILWECG GTLSASAISS GVIHKVHAFV APKIIGGKNA
PSPVGELGMV EMTQALELND VSYEQIERDM LISGYLQPIP DMRPVIPSVD ETSAIDPSLS
PYDSPIIFFY KTWDSYGSFS NFSHHPIRLP DENGHYVTWS SVEHYYQAHK FVGSSNPDAR
SYVEAIHSAK SPEEAAIMGR KLQREHPDMV RGDWESVKTE VMYKALKCKF SIYPHLNSML
LSTAGCVLVE ASPHDLFWGG GRDGEGLNYL GRLLMKLRSE FLGDDDTYYA EVSAGYRES
//
