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Database: UniProt
Entry: A0A251S066_HELAN
LinkDB: A0A251S066_HELAN
Original site: A0A251S066_HELAN 
ID   A0A251S066_HELAN        Unreviewed;      1392 AA.
AC   A0A251S066;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   31-JUL-2019, entry version 8.
DE   SubName: Full=Putative dicer-like 2 {ECO:0000313|EMBL:OTF91536.1};
GN   Name=DCL2 {ECO:0000313|EMBL:OTF91536.1};
GN   ORFNames=HannXRQ_Chr16g0511821 {ECO:0000313|EMBL:OTF91536.1};
OS   Helianthus annuus (Common sunflower).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
OC   Pentapetalae; asterids; campanulids; Asterales; Asteraceae;
OC   Asteroideae; Heliantheae alliance; Heliantheae; Helianthus.
OX   NCBI_TaxID=4232 {ECO:0000313|EMBL:OTF91536.1, ECO:0000313|Proteomes:UP000215914};
RN   [1] {ECO:0000313|Proteomes:UP000215914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. SF193 {ECO:0000313|Proteomes:UP000215914};
RX   PubMed=28538728; DOI=10.1038/nature22380;
RA   Badouin H., Gouzy J., Grassa C.J., Murat F., Staton S.E., Cottret L.,
RA   Lelandais-Briere C., Owens G.L., Carrere S., Mayjonade B., Legrand L.,
RA   Gill N., Kane N.C., Bowers J.E., Hubner S., Bellec A., Berard A.,
RA   Berges H., Blanchet N., Boniface M.C., Brunel D., Catrice O.,
RA   Chaidir N., Claudel C., Donnadieu C., Faraut T., Fievet G.,
RA   Helmstetter N., King M., Knapp S.J., Lai Z., Le Paslier M.C.,
RA   Lippi Y., Lorenzon L., Mandel J.R., Marage G., Marchand G.,
RA   Marquand E., Bret-Mestries E., Morien E., Nambeesan S., Nguyen T.,
RA   Pegot-Espagnet P., Pouilly N., Raftis F., Sallet E., Schiex T.,
RA   Thomas J., Vandecasteele C., Vares D., Vear F., Vautrin S., Crespi M.,
RA   Mangin B., Burke J.M., Salse J., Munos S., Vincourt P.,
RA   Rieseberg L.H., Langlade N.B.;
RT   "The sunflower genome provides insights into oil metabolism, flowering
RT   and Asterid evolution.";
RL   Nature 546:148-152(2017).
CC   -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC       {ECO:0000256|PROSITE-ProRule:PRU00657}.
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DR   EMBL; CM007905; OTF91536.1; -; Genomic_DNA.
DR   EnsemblPlants; OTF91536; OTF91536; HannXRQ_Chr16g0511821.
DR   Gramene; OTF91536; OTF91536; HannXRQ_Chr16g0511821.
DR   OMA; VWFLAPT; -.
DR   Proteomes; UP000215914; Chromosome 16.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 1.10.1520.10; -; 2.
DR   Gene3D; 3.30.160.380; -; 1.
DR   InterPro; IPR038248; Dicer_dimer_sf.
DR   InterPro; IPR005034; Dicer_dimerisation_dom.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF03368; Dicer_dimer; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF00636; Ribonuclease_3; 2.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF69065; SSF69065; 2.
DR   PROSITE; PS51327; DICER_DSRBF; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS00517; RNASE_3_1; 1.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000215914};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215914};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00657};
KW   RNA-mediated gene silencing {ECO:0000256|SAAS:SAAS00703041}.
FT   DOMAIN       28    193       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      368    538       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
FT   DOMAIN      557    643       Dicer dsRNA-binding fold.
FT                                {ECO:0000259|PROSITE:PS51327}.
FT   DOMAIN      834    931       PAZ. {ECO:0000259|PROSITE:PS50821}.
FT   DOMAIN      982   1114       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     1150   1297       RNase III. {ECO:0000259|PROSITE:PS50142}.
SQ   SEQUENCE   1392 AA;  158101 MW;  94A4998DA7275981 CRC64;
     MATHGSNAAV SESSDHQLSF ARSYQIEALA QAIKENTIVF LETGSGKTLI AIMLLRHYAY
     LLKKPSPYIA VFLVPTVVLV KQQAEYVRRH LDLKVEEYWG EKGVDFWNAA DWKKQRDQNQ
     LLVMTPDILR NALRHRFLTL DIIKVLIFDE CHNAKKNHAY AIIMKEFYHR ELLAGSSQLP
     RILGMTASPV KAKGSSSSEE YWKQISELEN LLRSKVYTCA SESVLAEHIP FSNAKYTFYK
     EMEIPCTFEE IKNTLSILRE KYVLAIRTST LLDSSKENAT SRLLRLSKQF EFCLYELGIW
     LAAKAAEAHS CEANDLYTWG TPDVRGEAIA RDFCKDVHNI LSSYIPPGWL VHHINKESVL
     SHGFLTTKVV CLIESLAEYR HVNDMRCIIF VERVISAIVL KTLLCELYPK LFGWKTEYTA
     GNNSVMQSQS RGAQNKIVDE FRKGTVNIIV ATSILEEGLD VQSCNLVIRF DLSNTVCSFI
     QSRGRARMRN SDFLLLIPSG DTETLEKVQN YLISGEIMRQ ESLNHASEPC APLDGDIMNE
     AVYHVESTGA SLSLSSSISM VYFYCSRLPS DGYFKPYPRF EIDKEAGTCV IYFPKSCPLP
     SVRVTGNVKM LKQLACLEAC KELHKLGALT DYLVPDTVEK ADIDAQEIAY DYVAEQVQYV
     PPELVGRYGN DSNKEYHFYS IKLKRNFEYD IPLQDMVLGV NNELELDNDR LEFDLEVDRG
     TIAVSITYIG TSFLTSHQIR TSYIFQVMVL RVLLDNAITK LKKFLEVITT KNNVTLFDYL
     LFPSMGLNKS PPVIDWTSVN SVAFLYAKQH NCSLTGNYHH QIHTINGVVC SCSMENALVY
     TPHNEHVYCT TKRLVGLNGN SSLQLKGEAI TYKNYYKTRH GIDLQYGDES FFAARQLFVV
     RNTLQKGRHH KEKETSNAGV ELPPELCYIL MSPIPITTFY SFSFVPSIMH RIESWLLALN
     LKKMHLDCSP SYGNVPASKI LEALTTKKCL EKFHLESLET LGDSFLKYAA SQQLFKKFQG
     QHEGILSSRR EKVISNASLC RLGCNRNLPG FVRNKPFDPK TWVVPGDLSE TFELGQMNLS
     TERKVYIGNK RTLKEKVVAD VVEALIGVFL SEGGEMAALS FMRWLGIKVD LVNTSYIREV
     TLQPEKYINI EHLESLLNYT FNDASLLVEA LTHGSYMLPE IPKCYQRLEF LGDAVLDYLI
     TVHLYNKYPG MSPGMLTDLR SASVNNDCYA QSAFKIELHK HILHGSQALH QHIVKIMREI
     DHLTLETTFG WESETSFPKV LGDVIESLAG AIFVDSGYDK DQVFNSIRPL LEPLVTPETL
     KLHPVKELHD LCQKNHYEIK KTAKRTEDGT VWFTIEVESE GEVFKESCMA SDKKMGERVA
     SKNVLKRIKE TI
//
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