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Database: UniProt
Entry: A0A251SGN4_HELAN
LinkDB: A0A251SGN4_HELAN
Original site: A0A251SGN4_HELAN 
ID   A0A251SGN4_HELAN        Unreviewed;       308 AA.
AC   A0A251SGN4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   16-OCT-2019, entry version 10.
DE   RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273};
DE            EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273};
GN   Name=TOPP4 {ECO:0000313|EMBL:OTF96620.1};
GN   ORFNames=HannXRQ_Chr15g0496141 {ECO:0000313|EMBL:OTF96620.1};
OS   Helianthus annuus (Common sunflower).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
OC   Pentapetalae; asterids; campanulids; Asterales; Asteraceae;
OC   Asteroideae; Heliantheae alliance; Heliantheae; Helianthus.
OX   NCBI_TaxID=4232 {ECO:0000313|EMBL:OTF96620.1, ECO:0000313|Proteomes:UP000215914};
RN   [1] {ECO:0000313|Proteomes:UP000215914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. SF193 {ECO:0000313|Proteomes:UP000215914};
RX   PubMed=28538728; DOI=10.1038/nature22380;
RA   Badouin H., Gouzy J., Grassa C.J., Murat F., Staton S.E., Cottret L.,
RA   Lelandais-Briere C., Owens G.L., Carrere S., Mayjonade B., Legrand L.,
RA   Gill N., Kane N.C., Bowers J.E., Hubner S., Bellec A., Berard A.,
RA   Berges H., Blanchet N., Boniface M.C., Brunel D., Catrice O.,
RA   Chaidir N., Claudel C., Donnadieu C., Faraut T., Fievet G.,
RA   Helmstetter N., King M., Knapp S.J., Lai Z., Le Paslier M.C.,
RA   Lippi Y., Lorenzon L., Mandel J.R., Marage G., Marchand G.,
RA   Marquand E., Bret-Mestries E., Morien E., Nambeesan S., Nguyen T.,
RA   Pegot-Espagnet P., Pouilly N., Raftis F., Sallet E., Schiex T.,
RA   Thomas J., Vandecasteele C., Vares D., Vear F., Vautrin S., Crespi M.,
RA   Mangin B., Burke J.M., Salse J., Munos S., Vincourt P.,
RA   Rieseberg L.H., Langlade N.B.;
RT   "The sunflower genome provides insights into oil metabolism, flowering
RT   and Asterid evolution.";
RL   Nature 546:148-152(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;
CC         Evidence={ECO:0000256|SAAS:SAAS01116782};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-
CC         [protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-
CC         COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977;
CC         EC=3.1.3.16; Evidence={ECO:0000256|RuleBase:RU004273,
CC         ECO:0000256|SAAS:SAAS01116780};
CC   -!- SIMILARITY: Belongs to the PPP phosphatase family.
CC       {ECO:0000256|RuleBase:RU004273, ECO:0000256|SAAS:SAAS01017257}.
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DR   EMBL; CM007904; OTF96620.1; -; Genomic_DNA.
DR   EnsemblPlants; OTF96620; OTF96620; HannXRQ_Chr15g0496141.
DR   Gramene; OTF96620; OTF96620; HannXRQ_Chr15g0496141.
DR   OMA; FQVLKHA; -.
DR   Proteomes; UP000215914; Chromosome 15.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR   InterPro; IPR031675; STPPase_N.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF16891; STPPase_N; 1.
DR   PRINTS; PR00114; STPHPHTASE.
DR   SMART; SM00156; PP2Ac; 1.
DR   PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000215914};
KW   Hydrolase {ECO:0000256|RuleBase:RU004273,
KW   ECO:0000256|SAAS:SAAS01017252};
KW   Manganese {ECO:0000256|SAAS:SAAS01017251};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01017255};
KW   Protein phosphatase {ECO:0000256|SAAS:SAAS01017274};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215914}.
FT   DOMAIN      118    123       SER_THR_PHOSPHATASE.
FT                                {ECO:0000259|PROSITE:PS00125}.
SQ   SEQUENCE   308 AA;  35086 MW;  71331EC2CCD66189 CRC64;
     MDPAALDRII ERLIEVRSNK PGKLVQLSEA EIKQLCLVSR DIFINQPNLL ELEAPIKICG
     DIHGQYSDLL RLFEYGGFPP QSNYLFLGDY VDRGKQSLET ICLLLAYKIR YPENFFLLRG
     NHECASINRI YGFYDECKRR FNVKLWKAFT DCFNCLPVAA LIDDKILCMH GGLSPDLSNL
     DQIRNLPRST AIPDTGLLCD LLWSDPCKDA KGWGMNDRGV SYTFGPDKVS EFLTNHDLDL
     VCRAHQVVED GYEFFADRQL VTIFSAPNYC GEFDNAGAMM SVDENLMCSF QILKPAEKKN
     KFLMSTKM
//
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