ID A0A251T5J0_HELAN Unreviewed; 671 AA.
AC A0A251T5J0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Chromatin regulator PHD family {ECO:0000313|EMBL:KAF5799732.1};
DE SubName: Full=Putative breast cancer associated RING 1 {ECO:0000313|EMBL:OTG06427.1};
GN Name=ATBARD1 {ECO:0000313|EMBL:OTG06427.1};
GN ORFNames=HannXRQ_Chr12g0385601 {ECO:0000313|EMBL:OTG06427.1},
GN HanXRQr2_Chr07g0307921 {ECO:0000313|EMBL:KAF5799732.1};
OS Helianthus annuus (Common sunflower).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae;
OC Heliantheae alliance; Heliantheae; Helianthus.
OX NCBI_TaxID=4232 {ECO:0000313|EMBL:OTG06427.1, ECO:0000313|Proteomes:UP000215914};
RN [1] {ECO:0000313|EMBL:KAF5799732.1, ECO:0000313|Proteomes:UP000215914}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. SF193 {ECO:0000313|Proteomes:UP000215914};
RC TISSUE=Leaves {ECO:0000313|EMBL:KAF5799732.1};
RX PubMed=28538728; DOI=10.1038/nature22380;
RA Badouin H., Gouzy J., Grassa C.J., Murat F., Staton S.E., Cottret L.,
RA Lelandais-Briere C., Owens G.L., Carrere S., Mayjonade B., Legrand L.,
RA Gill N., Kane N.C., Bowers J.E., Hubner S., Bellec A., Berard A.,
RA Berges H., Blanchet N., Boniface M.C., Brunel D., Catrice O., Chaidir N.,
RA Claudel C., Donnadieu C., Faraut T., Fievet G., Helmstetter N., King M.,
RA Knapp S.J., Lai Z., Le Paslier M.C., Lippi Y., Lorenzon L., Mandel J.R.,
RA Marage G., Marchand G., Marquand E., Bret-Mestries E., Morien E.,
RA Nambeesan S., Nguyen T., Pegot-Espagnet P., Pouilly N., Raftis F.,
RA Sallet E., Schiex T., Thomas J., Vandecasteele C., Vares D., Vear F.,
RA Vautrin S., Crespi M., Mangin B., Burke J.M., Salse J., Munos S.,
RA Vincourt P., Rieseberg L.H., Langlade N.B.;
RT "The sunflower genome provides insights into oil metabolism, flowering and
RT Asterid evolution.";
RL Nature 546:148-152(2017).
RN [2] {ECO:0000313|EMBL:OTG06427.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Leaves {ECO:0000313|EMBL:OTG06427.1};
RA Langlade N., Munos S.;
RT "Sunflower complete genome.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF5799732.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:KAF5799732.1};
RA Gouzy J., Langlade N., Munos S.;
RT "Helianthus annuus Genome sequencing and assembly Release 2.";
RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; MNCJ02000322; KAF5799732.1; -; Genomic_DNA.
DR EMBL; CM007901; OTG06427.1; -; Genomic_DNA.
DR STRING; 4232.A0A251T5J0; -.
DR EnsemblPlants; mRNA:HanXRQr2_Chr07g0307921; mRNA:HanXRQr2_Chr07g0307921; HanXRQr2_Chr07g0307921.
DR Gramene; mRNA:HanXRQr2_Chr07g0307921; mRNA:HanXRQr2_Chr07g0307921; HanXRQr2_Chr07g0307921.
DR InParanoid; A0A251T5J0; -.
DR OMA; NQQRESC; -.
DR OrthoDB; 318045at2759; -.
DR Proteomes; UP000215914; Chromosome 12.
DR GO; GO:0070531; C:BRCA1-A complex; IBA:GO_Central.
DR GO; GO:0031436; C:BRCA1-BARD1 complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IBA:GO_Central.
DR GO; GO:0035067; P:negative regulation of histone acetylation; IBA:GO_Central.
DR GO; GO:0035066; P:positive regulation of histone acetylation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd17734; BRCT_Bard1_rpt1; 1.
DR CDD; cd15571; ePHD; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR031099; BRCA1-associated.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13763:SF9; BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1; 1.
DR PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000215914};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 24..57
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 294..409
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 444..533
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 554..671
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 193..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 671 AA; 73561 MW; 3971E3914768319C CRC64;
MEEAQRLINP WVLHLQKLGL ELKCPICLQL FNRPVLLPCS HIFCSSCQIG MECAVCKHSY
IDREVKPAPF MENIVSIYRN LEATFTITSH VIHPVCSDIG KASVQDVNNS LKKENGVITK
EGNSSNDQST TLQTAVPDLT FGSLETLEKC ITPESVKKQE FKASGSSSKV QVAHDKHVET
RVDGVGFIPM EQLSPPLSCS DPNSNHEDSV RYSLKRPAEK DASGAKSNNH EGKRQKETDD
RSDDMKTERN VHLETNLSSE NVATASCNSE TESKKPVSGG QTDQMDLKSN PCAFCQCSKI
SEGSGALMAY AHGKEVKGNV SNFAKVTYVH EKCTEWAPQI YFHKGTVKNL ESEVARASKL
KCTSCGKKGA VLGCYVKSCQ RTYHVPCAYD IPDCRWDCID FLLLCPNHVS HKFPKEKKSK
AKKQVTEKTI STNVNRCTTL QDGGKNLVLC GSALSAEQKF MMVDFARTNG ALVLKYWRDN
VTHVIAATDA NGACTRTLKV LMAILNGKWV VTMEWLKACV DAGRVVNEEP YEVRLDTHGC
SGGPTAGRLR ALNNAPKLFN NTKFYFVGDF VQAFKSDLIN LVKTAGGTIS ETKDQLLSSD
HGGVGLDHAT YVVYNADLSI CAVVENEDSI KAQRLAAAEG VAQECGSRVV GHTWILESIA
ACSLLPLTSR V
//
