ID A0A251TXI7_HELAN Unreviewed; 758 AA.
AC A0A251TXI7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN Name=CAS1 {ECO:0000313|EMBL:OTG15463.1};
GN ORFNames=HannXRQ_Chr09g0260661 {ECO:0000313|EMBL:OTG15463.1};
OS Helianthus annuus (Common sunflower).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae;
OC Heliantheae alliance; Heliantheae; Helianthus.
OX NCBI_TaxID=4232 {ECO:0000313|EMBL:OTG15463.1, ECO:0000313|Proteomes:UP000215914};
RN [1] {ECO:0000313|Proteomes:UP000215914}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. SF193 {ECO:0000313|Proteomes:UP000215914};
RX PubMed=28538728; DOI=10.1038/nature22380;
RA Badouin H., Gouzy J., Grassa C.J., Murat F., Staton S.E., Cottret L.,
RA Lelandais-Briere C., Owens G.L., Carrere S., Mayjonade B., Legrand L.,
RA Gill N., Kane N.C., Bowers J.E., Hubner S., Bellec A., Berard A.,
RA Berges H., Blanchet N., Boniface M.C., Brunel D., Catrice O., Chaidir N.,
RA Claudel C., Donnadieu C., Faraut T., Fievet G., Helmstetter N., King M.,
RA Knapp S.J., Lai Z., Le Paslier M.C., Lippi Y., Lorenzon L., Mandel J.R.,
RA Marage G., Marchand G., Marquand E., Bret-Mestries E., Morien E.,
RA Nambeesan S., Nguyen T., Pegot-Espagnet P., Pouilly N., Raftis F.,
RA Sallet E., Schiex T., Thomas J., Vandecasteele C., Vares D., Vear F.,
RA Vautrin S., Crespi M., Mangin B., Burke J.M., Salse J., Munos S.,
RA Vincourt P., Rieseberg L.H., Langlade N.B.;
RT "The sunflower genome provides insights into oil metabolism, flowering and
RT Asterid evolution.";
RL Nature 546:148-152(2017).
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
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DR EMBL; CM007898; OTG15463.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251TXI7; -.
DR SMR; A0A251TXI7; -.
DR STRING; 4232.A0A251TXI7; -.
DR InParanoid; A0A251TXI7; -.
DR OMA; CWARQTI; -.
DR OrthoDB; 608at2759; -.
DR Proteomes; UP000215914; Chromosome 9.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016871; F:cycloartenol synthase activity; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU362003};
KW Reference proteome {ECO:0000313|Proteomes:UP000215914};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 100..399
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 413..750
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 758 AA; 86139 MW; 0CBC8386AE44A7D6 CRC64;
MWRLKIAEGG SPWLRTTNDH VGRQFWEFDP TLGSVEELAE IEKVRQTFHE NRFEKKHSSD
LLMRMQFAKE RSLSAFPPKV NIKDAEDITD DKVTNVLRRA IGFHSTLQAD DGHWPGDYGG
PMFLLPGLVI TLTITGALNA VLSKEHKREI CRYIYNHQNV DGGWGLHIEG HSTMFGSSLN
YVTLRLLGEG ANDGEGAMEK GRKWILDHGG ATYITSWGKF WLSVLGVFEW SGNNPMPPEM
WILPYFLPVH PGRMWCHCRM VYLPMSYLYG RKFVGPITST VLALRKELFT VPYHDINWND
ARNLCAKEDL YYPHPLVQDI LWATLDKFVE PVLMRWPGKK LREKALRTAM EHIHYEDENT
RYICIGPVNK VLNMLCCWAE DPNSEAFKLH LPRIPDFLWL AEDGMKMQGY NGSQLWDTAF
AIQAIIATNL IEDFGPTLKK GHMYIKNSQV LEDCDGDLDY WYRHISKGAW PFSTADHGWP
ISDCTAEGLK AALLLSKLPS ELVDEPLDAD RLYDAVNVIL SLQNSNGSFA TYELTRSYSW
LELVNPAETF GDIVIDYPYV ECTSAAIQAL VAFMKLYPGH RKEEVQRCIN KAAAFIESIQ
ASDGSWYGSW AVCFTYGTWF GVKGLVAAGK NYSNCSSIRK ACNFLLSKQL ASGGWGESYL
SCQNKVYTNL EGNRSHVVNT GWAMLALIDA EQAKRDPKPL HSAARVLINS QLENGDFPQE
EIMGVFNRNC MITYAAYRNI FPIWALGEYR CRVLQAQS
//
