ID A0A251UK12_HELAN Unreviewed; 1461 AA.
AC A0A251UK12;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN ORFNames=HannXRQ_Chr06g0174061 {ECO:0000313|EMBL:OTG22671.1};
OS Helianthus annuus (Common sunflower).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae;
OC Heliantheae alliance; Heliantheae; Helianthus.
OX NCBI_TaxID=4232 {ECO:0000313|EMBL:OTG22671.1, ECO:0000313|Proteomes:UP000215914};
RN [1] {ECO:0000313|Proteomes:UP000215914}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. SF193 {ECO:0000313|Proteomes:UP000215914};
RX PubMed=28538728; DOI=10.1038/nature22380;
RA Badouin H., Gouzy J., Grassa C.J., Murat F., Staton S.E., Cottret L.,
RA Lelandais-Briere C., Owens G.L., Carrere S., Mayjonade B., Legrand L.,
RA Gill N., Kane N.C., Bowers J.E., Hubner S., Bellec A., Berard A.,
RA Berges H., Blanchet N., Boniface M.C., Brunel D., Catrice O., Chaidir N.,
RA Claudel C., Donnadieu C., Faraut T., Fievet G., Helmstetter N., King M.,
RA Knapp S.J., Lai Z., Le Paslier M.C., Lippi Y., Lorenzon L., Mandel J.R.,
RA Marage G., Marchand G., Marquand E., Bret-Mestries E., Morien E.,
RA Nambeesan S., Nguyen T., Pegot-Espagnet P., Pouilly N., Raftis F.,
RA Sallet E., Schiex T., Thomas J., Vandecasteele C., Vares D., Vear F.,
RA Vautrin S., Crespi M., Mangin B., Burke J.M., Salse J., Munos S.,
RA Vincourt P., Rieseberg L.H., Langlade N.B.;
RT "The sunflower genome provides insights into oil metabolism, flowering and
RT Asterid evolution.";
RL Nature 546:148-152(2017).
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DR EMBL; CM007895; OTG22671.1; -; Genomic_DNA.
DR InParanoid; A0A251UK12; -.
DR OMA; FINEGMY; -.
DR Proteomes; UP000215914; Chromosome 6.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR InterPro; IPR045358; Ty3_capsid.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR45835:SF105; IPP TRANSFERASE; 1.
DR PANTHER; PTHR45835; YALI0A06105P; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF08284; RVP_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF19259; Ty3_capsid; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00343; ZnF_C2HC; 2.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
DR PROSITE; PS50158; ZF_CCHC; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000215914};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW ECO:0000313|EMBL:OTG22671.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 246..261
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 284..299
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 564..743
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1085..1248
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 170..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1437..1461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1439..1455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1461 AA; 167235 MW; 22BE700048082162 CRC64;
MDCKPLPFNG TEGAIGLLHW IEKIEAVFAV CECPPANWVK FATATLEGSA LSWWKAQIQM
FGLETANATA WEDFKDMIKD EYCHRDDIHK LENEYYELKM VGSEIETYTK LSNDYAALCP
NMSRPMYRRI ELYIKGLAPE IRSHVTSANH TTIQPIVRLA HKLTDQAVEE GRLPKRISAT
VGTSSDSKRK WEGSQSKDAN PTQAPAQQRK TENNKGTQQQ GGYRGSYPKC NKCNKHHNGA
CNKGLCQRCH KMGHDAKDCR NQFPARQNQQ QPQQQQQQGN NRACFKCGAE GHFKKDCPEL
NQNRNNNQGA GNNNQNNNAG NGARGRAFVI GAGEARNDPN VVTGKFLLDD RYVSVLFDSG
ADASYVSLRI SKKLKRPLSL LSSPHIVELA NGRNIEASHV VKGCKLELSG QTFSIDLFPV
TLGSFDVVIG MDWLSKHRAE ILCQEKAVRI PRRSGKPLIV QGSKSGEISG VISFLKAQKC
LRKGHTAILA LVTNTQEKEK RIEDFPVVRD YPEVFPEELP GLPPHRQVEF QIELAPGATP
IARAPYRLAP AELKELSTQL QELLDKGFIR PSSSPWGAPV LFVKKKDGTF RMCIDYRELN
KVTIKNRYPL PRIDDLFDQL QGSSYYSKID LRSGYHQLRV RSEDIPKTAF RTRYGHYEFL
VMPFGMTNAP AVFMDLMNRV CKPYLDKFVI VFIDDILIYS KSQEEHEQHL RLILELLRNE
QLYAKFSKCD FWLREVHFLG HVVNKDGIHV DPAKIDSIKN WPTPKTPTEV RQFLGLAGYY
RRFIQGFSKI AQPLTTLTQK GVTYKWNEAQ ESAFQRLKDN LCSAPILSLP EGTDDFVVYC
DASIHGLGCV LMQREKVIAY ASRQLKTHER NYTTHDLELG AVIFALKIWR HYLYGTKCTI
YTDHRSLEHI FKQKELNMRQ RRWVELLNDY ECAIKYHPGK ANVVADALSR KDTIPKRVRA
LQLTIQSSLP TQIRNAQVDA LKPENIRAES LRGSRQQLEQ KEDGAYYVAG RIWVPLYGDL
RELVMDEAHK SRYSVHPGAD KMYHDLKTTY WWPGMKAHIA AYVGKCLTCA RVKIEYQKPA
GLLQQPEIPK WKWEQISMDF VTGLPRSQRG NDTIWVIVDR LTKSAHFLAI KETDKFSTLA
EIYLKEVVSR HGVPTSIISD RDARFTSELW QAMHKCFGSR LDMSTAYHPQ TDGQSERTIQ
TLEDMLRACV IDFGKNWEKH LPLVEFSYNN SYHTSIQAAP FEALYGRKCR SPLCWAEVGD
SQLTGPELVV DTTEKISQIR QRMAAARDRQ KSYADKRRKP LEFQVGDRVL LKVSPWKGVV
RFGKRGKLNP RYVGPFEITE KIGKVAYRLN LPAELSAVHN VFHVSNLKKC LSDETLVIPF
KELTIDEQLH FTEEPIEIMD REIKTLKRSQ IPLVRVRWNS RRGPEFTWER EDQMKSKYPQ
LFPNENPSTE ATTEFRDEIP N
//
