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Database: UniProt
Entry: A0A251UK91_HELAN
LinkDB: A0A251UK91_HELAN
Original site: A0A251UK91_HELAN 
ID   A0A251UK91_HELAN        Unreviewed;      1000 AA.
AC   A0A251UK91;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Putative tRNA wybutosine-synthesizing protein {ECO:0000313|EMBL:OTG23790.1};
DE   SubName: Full=Transferase {ECO:0000313|EMBL:KAF5804117.1};
DE            EC=2.-.-.- {ECO:0000313|EMBL:KAF5804117.1};
GN   ORFNames=HannXRQ_Chr05g0129541 {ECO:0000313|EMBL:OTG23790.1},
GN   HannXRQ_Chr05g0129551 {ECO:0000313|EMBL:OTG23791.1},
GN   HanXRQr2_Chr05g0193451 {ECO:0000313|EMBL:KAF5804117.1};
OS   Helianthus annuus (Common sunflower).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae;
OC   Heliantheae alliance; Heliantheae; Helianthus.
OX   NCBI_TaxID=4232 {ECO:0000313|EMBL:OTG23790.1, ECO:0000313|Proteomes:UP000215914};
RN   [1] {ECO:0000313|EMBL:KAF5804117.1, ECO:0000313|Proteomes:UP000215914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. SF193 {ECO:0000313|Proteomes:UP000215914};
RC   TISSUE=Leaves {ECO:0000313|EMBL:KAF5804117.1};
RX   PubMed=28538728; DOI=10.1038/nature22380;
RA   Badouin H., Gouzy J., Grassa C.J., Murat F., Staton S.E., Cottret L.,
RA   Lelandais-Briere C., Owens G.L., Carrere S., Mayjonade B., Legrand L.,
RA   Gill N., Kane N.C., Bowers J.E., Hubner S., Bellec A., Berard A.,
RA   Berges H., Blanchet N., Boniface M.C., Brunel D., Catrice O., Chaidir N.,
RA   Claudel C., Donnadieu C., Faraut T., Fievet G., Helmstetter N., King M.,
RA   Knapp S.J., Lai Z., Le Paslier M.C., Lippi Y., Lorenzon L., Mandel J.R.,
RA   Marage G., Marchand G., Marquand E., Bret-Mestries E., Morien E.,
RA   Nambeesan S., Nguyen T., Pegot-Espagnet P., Pouilly N., Raftis F.,
RA   Sallet E., Schiex T., Thomas J., Vandecasteele C., Vares D., Vear F.,
RA   Vautrin S., Crespi M., Mangin B., Burke J.M., Salse J., Munos S.,
RA   Vincourt P., Rieseberg L.H., Langlade N.B.;
RT   "The sunflower genome provides insights into oil metabolism, flowering and
RT   Asterid evolution.";
RL   Nature 546:148-152(2017).
RN   [2] {ECO:0000313|EMBL:OTG23790.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Leaves {ECO:0000313|EMBL:OTG23790.1};
RA   Langlade N., Munos S.;
RT   "Sunflower complete genome.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KAF5804117.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Leaves {ECO:0000313|EMBL:KAF5804117.1};
RA   Gouzy J., Langlade N., Munos S.;
RT   "Helianthus annuus Genome sequencing and assembly Release 2.";
RL   Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in
CC         tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-
CC         carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:36635, Rhea:RHEA-COMP:10378, Rhea:RHEA-
CC         COMP:10379, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:73543, ChEBI:CHEBI:73550; EC=2.1.1.282;
CC         Evidence={ECO:0000256|ARBA:ARBA00001168};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine =
CC         4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) +
CC         H(+) + S-methyl-5'-thioadenosine; Xref=Rhea:RHEA:36355, Rhea:RHEA-
CC         COMP:10164, Rhea:RHEA-COMP:10378, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17509, ChEBI:CHEBI:59789, ChEBI:CHEBI:64315,
CC         ChEBI:CHEBI:73550; EC=2.5.1.114;
CC         Evidence={ECO:0000256|ARBA:ARBA00036405};
CC   -!- PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004797}.
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DR   EMBL; MNCJ02000320; KAF5804117.1; -; Genomic_DNA.
DR   EMBL; CM007894; OTG23790.1; -; Genomic_DNA.
DR   EMBL; CM007894; OTG23791.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A251UK91; -.
DR   STRING; 4232.A0A251UK91; -.
DR   EnsemblPlants; mRNA:HanXRQr2_Chr05g0193451; mRNA:HanXRQr2_Chr05g0193451; HanXRQr2_Chr05g0193451.
DR   Gramene; mRNA:HanXRQr2_Chr05g0193451; mRNA:HanXRQr2_Chr05g0193451; HanXRQr2_Chr05g0193451.
DR   OMA; AVECKDL; -.
DR   OrthoDB; 122704at2759; -.
DR   UniPathway; UPA00375; -.
DR   Proteomes; UP000215914; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR   GO; GO:0102522; F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008175; F:tRNA methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR   GO; GO:0031591; P:wybutosine biosynthetic process; IBA:GO_Central.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR   Gene3D; 3.30.300.110; Met-10+ protein-like domains; 1.
DR   Gene3D; 3.30.1960.10; tRNA wybutosine-synthesizing-like; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR030382; MeTrfase_TRM5/TYW2.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR003827; tRNA_yW-synthesising.
DR   InterPro; IPR036602; tRNA_yW-synthesising-like_sf.
DR   PANTHER; PTHR23245; TRNA METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR23245:SF25; TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG; 1.
DR   Pfam; PF13415; Kelch_3; 1.
DR   Pfam; PF13418; Kelch_4; 1.
DR   Pfam; PF02475; Met_10; 1.
DR   Pfam; PF02676; TYW3; 1.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; Kelch motif; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF111278; SSo0622-like; 1.
DR   PROSITE; PS51684; SAM_MT_TRM5_TYW2; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215914};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KAF5804117.1};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT   DOMAIN          738..997
FT                   /note="SAM-dependent methyltransferase TRM5/TYW2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51684"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1000 AA;  110201 MW;  E29F0697AAFF7C27 CRC64;
     MEFEKRKKAT LATMTSSEPD KSPKGDIDTP LIPLLQTLNS HPSYFTTSSC SGRISILSTP
     TAAATTAVKK KAKGGTWVFI THEPADPFSV QNLIFPPNPT QNDIQENLVF RFEPLIIAVE
     CKDVLSAQKL VSLAISCGFR ESGITNVSSK RVIVAIRCSI RLEVPLGETC KIMVSKEYLN
     YLVGIANEKM EANRKRTDSF HDALLRNEFI ARPEISTGSG DCEFLNLNQD LGDKDCSMVT
     AGLEDIQLTS EIKDGASNGV PELPIKPMVI TGEPVEKLHL WGHSACTLET TKNPKSVFVF
     GGFGGVGRHA RRKDSWLLDS VSGQLQLVDF SSTPSPRLGH TASLAGELMF VIGGRADPGN
     VLNDVWVLNT TNNDWKQVLC TGIGFPHSHR HASAVIGSSL YVFGGIQNGS ISSGMYRLDT
     QNLTWEEVVV QGQIPSPRHS HTLVAHGAQL FMFGGYDGSK ALGDFYSFDI HSCTWKKEKM
     VGSTPYARFS HAMFVYKNYI GVMGGCPIKQ HYQELSVLKV GSSVWKRIKL SSVGEDLFVR
     STTSVVGDDL VIVGGGASCY AFGTKFSEPM KLNLLSLVSF AEPFNETEDQ SNIDLKTMVP
     LRWVLRVDKK HAKPAKDILK KFGWLDAERK VYTQENGVHV CFPITKEFVA LYQNKKPDIN
     GVVNEVSNLN LQEILKVVSS ARALDLLAAL GATTHADHIV KVKKASSSPL KVMKDAVASL
     LNRHNLPTTL LEQLPTRWER LGDIVVLPMT SFKDSVWDTL GKELWLTVAD SLGATRLARQ
     GKVSPTGTRD SGLEILVGVN GWVDHRENGV LYSFDATKCM FSWGNLSEKR RMGQLDCKQE
     VIVDLFAGIG YFTLPFLVKA NAKMVYACEW NPHAIEALRR NLEANGVADR CVVLEGDNRA
     TAPKGVADRV NLGLLPSSEG SWITAVKALR SEGGMMHVHG NVKDSEEDSW TEQVSKSIKE
     ISRSEGYNWD VSVEHVERVK WYAPHIRHLV VDIKCKQIDS
//
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