ID A0A251UNX9_HELAN Unreviewed; 499 AA.
AC A0A251UNX9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Actinidain {ECO:0000313|EMBL:KAF5810867.1};
DE EC=3.4.22.14 {ECO:0000313|EMBL:KAF5810867.1};
DE SubName: Full=Putative granulin, Cysteine peptidase, histidine active site protein {ECO:0000313|EMBL:OTG24723.1};
GN ORFNames=HannXRQ_Chr05g0139861 {ECO:0000313|EMBL:OTG24723.1},
GN HanXRQr2_Chr04g0174741 {ECO:0000313|EMBL:KAF5810867.1};
OS Helianthus annuus (Common sunflower).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae;
OC Heliantheae alliance; Heliantheae; Helianthus.
OX NCBI_TaxID=4232 {ECO:0000313|EMBL:OTG24723.1, ECO:0000313|Proteomes:UP000215914};
RN [1] {ECO:0000313|EMBL:KAF5810867.1, ECO:0000313|Proteomes:UP000215914}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. SF193 {ECO:0000313|Proteomes:UP000215914};
RC TISSUE=Leaves {ECO:0000313|EMBL:KAF5810867.1};
RX PubMed=28538728; DOI=10.1038/nature22380;
RA Badouin H., Gouzy J., Grassa C.J., Murat F., Staton S.E., Cottret L.,
RA Lelandais-Briere C., Owens G.L., Carrere S., Mayjonade B., Legrand L.,
RA Gill N., Kane N.C., Bowers J.E., Hubner S., Bellec A., Berard A.,
RA Berges H., Blanchet N., Boniface M.C., Brunel D., Catrice O., Chaidir N.,
RA Claudel C., Donnadieu C., Faraut T., Fievet G., Helmstetter N., King M.,
RA Knapp S.J., Lai Z., Le Paslier M.C., Lippi Y., Lorenzon L., Mandel J.R.,
RA Marage G., Marchand G., Marquand E., Bret-Mestries E., Morien E.,
RA Nambeesan S., Nguyen T., Pegot-Espagnet P., Pouilly N., Raftis F.,
RA Sallet E., Schiex T., Thomas J., Vandecasteele C., Vares D., Vear F.,
RA Vautrin S., Crespi M., Mangin B., Burke J.M., Salse J., Munos S.,
RA Vincourt P., Rieseberg L.H., Langlade N.B.;
RT "The sunflower genome provides insights into oil metabolism, flowering and
RT Asterid evolution.";
RL Nature 546:148-152(2017).
RN [2] {ECO:0000313|EMBL:OTG24723.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Leaves {ECO:0000313|EMBL:OTG24723.1};
RA Langlade N., Munos S.;
RT "Sunflower complete genome.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF5810867.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:KAF5810867.1};
RA Gouzy J., Langlade N., Munos S.;
RT "Helianthus annuus Genome sequencing and assembly Release 2.";
RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; MNCJ02000319; KAF5810867.1; -; Genomic_DNA.
DR EMBL; CM007894; OTG24723.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251UNX9; -.
DR STRING; 4232.A0A251UNX9; -.
DR EnsemblPlants; mRNA:HanXRQr2_Chr04g0174741; mRNA:HanXRQr2_Chr04g0174741; HanXRQr2_Chr04g0174741.
DR Gramene; mRNA:HanXRQr2_Chr04g0174741; mRNA:HanXRQr2_Chr04g0174741; HanXRQr2_Chr04g0174741.
DR InParanoid; A0A251UNX9; -.
DR OMA; SCEDAPY; -.
DR OrthoDB; 5472443at2759; -.
DR Proteomes; UP000215914; Chromosome 5.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 2.10.25.160; Granulin; 1.
DR InterPro; IPR000118; Granulin.
DR InterPro; IPR037277; Granulin_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF950; PROBABLE THIOL PROTEASE-RELATED; 1.
DR Pfam; PF00396; Granulin; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00277; GRAN; 1.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF57277; Granulin repeat; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000313|EMBL:KAF5810867.1};
KW Protease {ECO:0000256|ARBA:ARBA00022807};
KW Reference proteome {ECO:0000313|Proteomes:UP000215914};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..499
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018532008"
FT DOMAIN 56..115
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 149..369
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT DOMAIN 399..456
FT /note="Granulins"
FT /evidence="ECO:0000259|SMART:SM00277"
FT REGION 373..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 499 AA; 55131 MW; 6B487BF8421F0EE2 CRC64;
MGTSNFILTL LLLIIYVSSL SSSSPISLSS TLPPEFSILH GQENDVLSTE RVSELFVKWK
EVHGKVYDHQ EEEERRLGNF RNSLKFILER NSKRKSEWDH TVGLTKFADL SNEEFKEMYF
SKSKGPKSEK LKVWGEKGNT TLNSGSCDAP ASLDWRDKGV VTPMKDQGQC GSCWAFSVTG
SIEGAHAIAT GDLISLSEQE LVSCDTNDYG CDGGNMDTAY RWIIKNGGLN SEEAYPYTSS
NGRDGKCDKE KSQISVVSIS SYVEVESNED AVLCAVAKQP VTIGICGSAY DFQLYTGGIY
NGQCSSSAYS LDHAVLIVGY GTQDGEDYWI VKNQWGTYWG LEGYVLMKRG SDVNKNGVCG
MYLEAMYPIP AEPSPPSPPA PPSPPHPPPP PPAPTPDKCG NFHYCAADQT CCCILEFYNY
CFMYGCCGYT NAVCCKGSSY CCPSDYPVCD IQAGYCFKKS GGTFGVAAKK RQMAKHKMPW
EKVEETVMEE YQPMVWKRK
//
