ID A0A251VRI9_HELAN Unreviewed; 323 AA.
AC A0A251VRI9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=3'-5' exonuclease {ECO:0000256|ARBA:ARBA00040531};
DE AltName: Full=Werner Syndrome-like exonuclease {ECO:0000256|ARBA:ARBA00042761};
GN Name=WRNEXO {ECO:0000313|EMBL:OTG37743.1};
GN ORFNames=HannXRQ_Chr01g0022161 {ECO:0000313|EMBL:OTG37743.1},
GN HanXRQr2_Chr01g0033621 {ECO:0000313|EMBL:KAF5823013.1};
OS Helianthus annuus (Common sunflower).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae;
OC Heliantheae alliance; Heliantheae; Helianthus.
OX NCBI_TaxID=4232 {ECO:0000313|EMBL:OTG37743.1, ECO:0000313|Proteomes:UP000215914};
RN [1] {ECO:0000313|EMBL:KAF5823013.1, ECO:0000313|Proteomes:UP000215914}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. SF193 {ECO:0000313|Proteomes:UP000215914};
RC TISSUE=Leaves {ECO:0000313|EMBL:KAF5823013.1};
RX PubMed=28538728; DOI=10.1038/nature22380;
RA Badouin H., Gouzy J., Grassa C.J., Murat F., Staton S.E., Cottret L.,
RA Lelandais-Briere C., Owens G.L., Carrere S., Mayjonade B., Legrand L.,
RA Gill N., Kane N.C., Bowers J.E., Hubner S., Bellec A., Berard A.,
RA Berges H., Blanchet N., Boniface M.C., Brunel D., Catrice O., Chaidir N.,
RA Claudel C., Donnadieu C., Faraut T., Fievet G., Helmstetter N., King M.,
RA Knapp S.J., Lai Z., Le Paslier M.C., Lippi Y., Lorenzon L., Mandel J.R.,
RA Marage G., Marchand G., Marquand E., Bret-Mestries E., Morien E.,
RA Nambeesan S., Nguyen T., Pegot-Espagnet P., Pouilly N., Raftis F.,
RA Sallet E., Schiex T., Thomas J., Vandecasteele C., Vares D., Vear F.,
RA Vautrin S., Crespi M., Mangin B., Burke J.M., Salse J., Munos S.,
RA Vincourt P., Rieseberg L.H., Langlade N.B.;
RT "The sunflower genome provides insights into oil metabolism, flowering and
RT Asterid evolution.";
RL Nature 546:148-152(2017).
RN [2] {ECO:0000313|EMBL:OTG37743.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Leaves {ECO:0000313|EMBL:OTG37743.1};
RA Langlade N., Munos S.;
RT "Sunflower complete genome.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF5823013.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:KAF5823013.1};
RA Gouzy J., Langlade N., Munos S.;
RT "Helianthus annuus Genome sequencing and assembly Release 2.";
RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; MNCJ02000316; KAF5823013.1; -; Genomic_DNA.
DR EMBL; CM007890; OTG37743.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251VRI9; -.
DR STRING; 4232.A0A251VRI9; -.
DR EnsemblPlants; mRNA:HanXRQr2_Chr01g0033621; mRNA:HanXRQr2_Chr01g0033621; HanXRQr2_Chr01g0033621.
DR Gramene; mRNA:HanXRQr2_Chr01g0033621; mRNA:HanXRQr2_Chr01g0033621; HanXRQr2_Chr01g0033621.
DR InParanoid; A0A251VRI9; -.
DR OMA; HIVYSRT; -.
DR OrthoDB; 318506at2759; -.
DR Proteomes; UP000215914; Chromosome 1.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IBA:GO_Central.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd06141; WRN_exo; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR13620; 3-5 EXONUCLEASE; 1.
DR PANTHER; PTHR13620:SF109; WERNER SYNDROME-LIKE EXONUCLEASE; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:KAF5823013.1};
KW Exonuclease {ECO:0000313|EMBL:OTG37743.1};
KW Helicase {ECO:0000313|EMBL:KAF5823013.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:KAF5823013.1};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000313|EMBL:KAF5823013.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000215914}.
FT DOMAIN 126..305
FT /note="3'-5' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00474"
FT REGION 38..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 323 AA; 35752 MW; 063DAE3E0207F8BD CRC64;
MDTPKSDLNQ QSSSTVSAFS DWDIDFTEEE LQSIEAIFQS ATSSSSSRKP PVADCDGDRP
KTRRRLPDSL FNFTEQSAFS SHNASSSSSL LPCPRNRFRS CHRATPKMRY PAMTFKGHIV
YSRTFSEVEK AADELLRFVE TKNSDGSRAA IGFDIEWRPS FKKGVAQSKA AVLQICADAA
RCHVMHIIHS GFPQNLKTLL ADSRFIKVGV GIAGDARKVF NDHNVSVDAL EDLSRLANKK
LGGEPKMWGL SSLTEKLTCK QVLKPSKIRL GNWEANPLSV EQLKYAATDA FVSWHLHEVL
NRLPDPDTHT NEGVEAVAPP SVS
//
