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Database: UniProt
Entry: A0A251VX03_9CHLR
LinkDB: A0A251VX03_9CHLR
Original site: A0A251VX03_9CHLR 
ID   A0A251VX03_9CHLR        Unreviewed;       347 AA.
AC   A0A251VX03;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   16-JAN-2019, entry version 5.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=RY27_21695 {ECO:0000313|EMBL:OUC06338.1};
OS   Litorilinea aerophila.
OC   Bacteria; Chloroflexi; Caldilineae; Caldilineales; Caldilineaceae;
OC   Litorilinea.
OX   NCBI_TaxID=1204385 {ECO:0000313|EMBL:OUC06338.1};
RN   [1] {ECO:0000313|EMBL:OUC06338.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PRI-413 {ECO:0000313|EMBL:OUC06338.1};
RA   Hemp J., Slotznick S.P., Ward L.M., Pace L.A., Fischer W.;
RT   "Draft genome of Litorilinea aerophila, an aerobic member of the
RT   Chloroflexi class Caldilineae.";
RL   Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OUC06338.1}.
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DR   EMBL; JWSX01001931; OUC06338.1; -; Genomic_DNA.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR022697; HDH_short.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF036497; HDH_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR036497-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN       11    150       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      160    336       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND      11     16       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   ACT_SITE    227    227       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR036497-1}.
FT   BINDING     128    128       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     212    212       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR036497-2}.
SQ   SEQUENCE   347 AA;  37369 MW;  76F1DF94333CB12C CRC64;
     MTMHVDLGLI GLGHVGQQVL RILETRGDRL QRRYGVHLRV VCVADSSGVA VNPAGYDPAE
     VRHWKEAGGQ VAGLTGFRPG QRPAQALVEG PCQMVLEATP VNLQDGEPGL GVVRSALAQG
     IHVVLANKGP LVLAYQELHR LAAAHGAGLA FSATVCGGLP VINTGQRDLI GAEILALRGI
     FNSTSNFILS EMAAGRAFDE ALAEAQRRGI AEADPSLDVE GWDTANKLVI LANSVLGIPA
     TLQEISVTGI TGITTQDLEQ SQRRDRTIKL VAQAIREETG YRLSVMPMEL DQDEFLAQCQ
     SWEMGIEIQT DLYGTLYQKI WEQDPLPTAA AMIRDAVHLS QQFISRA
//
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