ID A0A251WDQ0_9CYAN Unreviewed; 518 AA.
AC A0A251WDQ0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Circadian clock oscillator protein KaiC {ECO:0000256|HAMAP-Rule:MF_01836};
DE EC=2.7.11.1 {ECO:0000256|HAMAP-Rule:MF_01836};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_01836};
GN Name=kaiC {ECO:0000256|HAMAP-Rule:MF_01836};
GN ORFNames=B0A82_15560 {ECO:0000313|EMBL:OUC13720.1};
OS Alkalinema sp. CACIAM 70d.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Leptolyngbyales; Leptolyngbyaceae;
OC Alkalinema.
OX NCBI_TaxID=1934309 {ECO:0000313|EMBL:OUC13720.1, ECO:0000313|Proteomes:UP000194922};
RN [1] {ECO:0000313|EMBL:OUC13720.1, ECO:0000313|Proteomes:UP000194922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CACIAM 70d {ECO:0000313|EMBL:OUC13720.1};
RA Lima A.R., Siqueira A.S., Pereira J.S., Goncalves E.C.;
RT "Draft genome of Alkalinema sp. CACIAM 70d.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the KaiC family. {ECO:0000256|HAMAP-
CC Rule:MF_01836}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_01836}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUC13720.1}.
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DR EMBL; MUGG01000133; OUC13720.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251WDQ0; -.
DR STRING; 1934309.B0A82_15560; -.
DR Proteomes; UP000194922; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007623; P:circadian rhythm; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0042752; P:regulation of circadian rhythm; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19485; KaiC-N; 1.
DR CDD; cd19484; KaiC_C; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01836; KaiC; 1.
DR InterPro; IPR013503; Circadian_KaiC_bact.
DR InterPro; IPR030665; KaiC.
DR InterPro; IPR014774; KaiC-like_dom.
DR InterPro; IPR047222; KaiC_C.
DR InterPro; IPR010624; KaiC_dom.
DR InterPro; IPR047221; KaiC_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02655; circ_KaiC; 1.
DR PANTHER; PTHR42926; -; 1.
DR PANTHER; PTHR42926:SF1; KAIC-LIKE PROTEIN 2; 1.
DR Pfam; PF06745; ATPase; 2.
DR PIRSF; PIRSF039117; KaiC; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51146; KAIC; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01836};
KW Biological rhythms {ECO:0000256|HAMAP-Rule:MF_01836};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01836};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|HAMAP-Rule:MF_01836};
KW Magnesium {ECO:0000256|HAMAP-Rule:MF_01836};
KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_01836};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01836};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|HAMAP-
KW Rule:MF_01836}; Reference proteome {ECO:0000313|Proteomes:UP000194922};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|HAMAP-Rule:MF_01836};
KW Repressor {ECO:0000256|HAMAP-Rule:MF_01836};
KW Serine/threonine-protein kinase {ECO:0000256|HAMAP-Rule:MF_01836};
KW Transcription {ECO:0000256|HAMAP-Rule:MF_01836};
KW Transcription regulation {ECO:0000256|HAMAP-Rule:MF_01836};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_01836}.
FT DOMAIN 19..260
FT /note="KaiC"
FT /evidence="ECO:0000259|PROSITE:PS51146"
FT DOMAIN 261..493
FT /note="KaiC"
FT /evidence="ECO:0000259|PROSITE:PS51146"
FT BINDING 49
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 50
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 51
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 52
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 53
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 53
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 54
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 89
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 224
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 225
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 226
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 228
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 230
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 241
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 290
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 291
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 292
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 293
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 294
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 295
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 295
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 296
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 318
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 331
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 451
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 457
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 458
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 459
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 461
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 463
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 465
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT MOD_RES 431
FT /note="Phosphoserine; by autocatalysis"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT MOD_RES 432
FT /note="Phosphothreonine; by autocatalysis"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
SQ SEQUENCE 518 AA; 57654 MW; C5A1DA07267F9626 CRC64;
MDANKQSEPR SRSELVGVQK IRTMIEGFDD ISHGGFPVGR TSLVSGTSGT GKTLFAVQFL
YNGITQFDEA GIFVTFEEST ADIIKNAVSF GWDLQKLIDE GKLFVLDASP DPEGQEVVGN
FDFSALIERI QYAIRKYKAK RVSIDSVTAL FQQYDSASVV RREILRLVSR LKQIGVTTVI
TTERTEEYGP VARFGVEEFV SDNVVIVRNV LEGERRRRTM EILKLRGTTH MKGEYPFTIT
DQGINIFPLG AMRLTQRSSN ARVSSGVKTL DEMCGGGFFK DSIILATGAT GTGKTLLVSK
FLQEGCMQGE RAILFAYEES RAQLSRNAYS WGIDFEELEQ QGLLKIICAY PESAGLEDHL
QIIKSEIAEF KPTRIAIDSL SALARGVSNN AFRQFVIGVT GFAKQEEITG FFTNTTDQFM
GSHSITDSHI STITDTIIML QYVEIRGEMS RALNVFKMRG SWHDKGIREY TISAQGPEIK
DSFRNFERII SGSPSRIAID EKTELGRIAK GLKLDDSL
//
