ID A0A251X5C5_9GAMM Unreviewed; 362 AA.
AC A0A251X5C5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=Intermembrane phospholipid transport system permease protein MlaE {ECO:0000256|ARBA:ARBA00020857};
GN ORFNames=TPSD3_16330 {ECO:0000313|EMBL:OUD12703.1};
OS Thioflexithrix psekupsensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Thioflexithrix.
OX NCBI_TaxID=1570016 {ECO:0000313|EMBL:OUD12703.1, ECO:0000313|Proteomes:UP000194798};
RN [1] {ECO:0000313|EMBL:OUD12703.1, ECO:0000313|Proteomes:UP000194798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D3 {ECO:0000313|EMBL:OUD12703.1};
RA Fomenkov A., Vincze T., Grabovich M., Anton B.P., Dubinina G., Orlova M.,
RA Belousova E., Roberts R.J.;
RT "Thioflexothrix psekupsii D3 genome sequencing and assembly.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ABC transporter complex MlaFEDB, which is
CC involved in a phospholipid transport pathway that maintains lipid
CC asymmetry in the outer membrane by retrograde trafficking of
CC phospholipids from the outer membrane to the inner membrane. Probably
CC responsible for the translocation of the substrate across the membrane.
CC {ECO:0000256|ARBA:ARBA00002460}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MlaF),
CC two transmembrane proteins (MlaE), two cytoplasmic solute-binding
CC proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).
CC {ECO:0000256|ARBA:ARBA00011380}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU362044}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU362044}.
CC -!- SIMILARITY: Belongs to the MlaE permease family.
CC {ECO:0000256|RuleBase:RU362044}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUD12703.1}.
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DR EMBL; MSLT01000023; OUD12703.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A251X5C5; -.
DR OrthoDB; 9810518at2; -.
DR Proteomes; UP000194798; Unassembled WGS sequence.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR003453; ABC_MlaE_roteobac.
DR InterPro; IPR030802; Permease_MalE.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00056; MlaE family lipid ABC transporter permease subunit; 1.
DR PANTHER; PTHR30188:SF3; ABC TRANSPORTER PERMEASE PROTEIN; 1.
DR PANTHER; PTHR30188; ABC TRANSPORTER PERMEASE PROTEIN-RELATED; 1.
DR Pfam; PF02405; MlaE; 1.
DR Pfam; PF13466; STAS_2; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU362044};
KW Cell membrane {ECO:0000256|RuleBase:RU362044};
KW Membrane {ECO:0000256|RuleBase:RU362044};
KW Reference proteome {ECO:0000313|Proteomes:UP000194798};
KW Transmembrane {ECO:0000256|RuleBase:RU362044};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362044}.
FT TRANSMEM 149..173
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362044"
FT TRANSMEM 179..197
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362044"
FT TRANSMEM 243..262
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362044"
FT TRANSMEM 268..287
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362044"
FT TRANSMEM 299..322
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362044"
FT TRANSMEM 342..360
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362044"
FT DOMAIN 10..83
FT /note="STAS"
FT /evidence="ECO:0000259|Pfam:PF13466"
SQ SEQUENCE 362 AA; 38852 MW; CA5254906F21CADF CRC64;
MQNDDQCTCQ GVWTLDTIAP LEKILRHFSQ HASQEKITVD GSGIIRLDSA GAWLLHRTRM
DLEARGRQVQ WQGFSAAQQT LLDNLKNYDI APVVSSVSTG VCTDVGYHTV ALGREVVSFL
AFLGENTAVA LRILIQPSRI RWREVMSNVY HSGVTALPIV GLMSFLIGVV IAYQGGVQLK
LYGANILVAD LVGITLLREL APLLTAIIIA GRSGSAYTAQ IGTMVVTEEV DALRTIGISP
LELLVFPKVM ALVVMLPLLT AYADVMGILG GMVIAFLTLE VGFAEFLDRL QQTVTITTYL
VGVGKAPVFA VIIALVGCYH GFQASGSADS VGQKVTTSVV QAIFLVIVSD AVFAILFGWV
GI
//
