ID A0A252BJQ5_9PROT Unreviewed; 2117 AA.
AC A0A252BJQ5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:OUJ05447.1};
GN ORFNames=HK24_12145 {ECO:0000313|EMBL:OUJ05447.1};
OS Gluconobacter sp. DsW_058.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae; Gluconobacter.
OX NCBI_TaxID=1511210 {ECO:0000313|EMBL:OUJ05447.1, ECO:0000313|Proteomes:UP000194786};
RN [1] {ECO:0000313|Proteomes:UP000194786}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Winans N.J., Newell P.D., Douglas A.E.;
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUJ05447.1}.
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DR EMBL; JOPH01000068; OUJ05447.1; -; Genomic_DNA.
DR Proteomes; UP000194786; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000194786};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..435
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2031..2108
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2117 AA; 227599 MW; 81797C510BA75F43 CRC64;
MIDYGHEVAV VGIGCRLPGG IETTEALWRF LCEQGDATSD VPADRWGIKR FYDPEYETPN
KTYMRRGSFI DQKIDEMDPL FFGISPREAT LMDPQQRLLL EVVWEAMENA GILPATLAGT
RTGVFIGTFS LDWLVACGSP LNRPLITDHF AATAASATML AARISHNLGL QGPCMSIDTA
CSSSLVAIHQ ARISLLNGES DVVVAGGVNI MVAPPASITM SKGHFLAADG RCKSFSADAD
GYGRGEGAGI VLLKRLADAK RDGDVIHGVI AGTGVNQDGR TLSLTMPSED AQRALIEEVA
QKAHIDLATI GYVEAHGTGT PVGDPIEARA LGTAIGHKRA SDSPLIVGSI KANLGHLEAA
AGVTGLIKAL LCLKHGAIPP QANLTQVNPA IPFADLHLKV AQDTLTPLKA EAGTVYAGVN
SFGYGGTNAV ALLRAPTVAD QPQKRLEEIV RMPSGRFLLP VNALVDASLK TLARSYASLL
ASSATPSVAN VCFSAATYRT RLPMQAVVSG RDREELIAGL KALSEGQSSP AVTVGRRRNG
EMQHPVFVFS GMGSQWKGMG QHILRHAPEP VSSTIQQIDS LFSALAGWSI LDEILKPAEH
SRIDETVVAQ PAIFMVQVVL AELFRFHGVV PAAIVGHSVG EVAASYIAGA LSLEDAVTVI
FHRSQQQARL AGRGAMLAIG MSGRQAAEKL LPSYEDRVSV AALNSAKSAT LAGEEAALKE
LAVRCDQDGT FNRLLRVEVP YHSILMEEIR DDLLNPLAAL APKNPNIPLY STVTGTRWAD
DALHDAEYWY GNARQPVLFH DAIQNLMGDG HRVFLEIGAH PVLGGLIRET AQQIDGDVAV
IASLSRKDAE DTAIARSIAK LYMAAVPLDW SLLTGGHRTD LPHYAWSRSR FWSETEVSRK
DRLDGTVHPV LGIPVSASRP GWLADINRNY MPWLPDHKVD GICLFPAAGY IEGGLALHRQ
IERSDTAILE DLEIGQALLL DSLTPPVVEW AFDEETRVLT VSSSHGDDGE EEWIQHAKLR
VLTSVPWAAD PVVPERLQAD LKHEILPETF YARLAEHGFS YGSTFQTIKE LKAGEGIAFA
RLELADAESI AEYFLHPALL DGAFQALIGA GYSAAEERVF VPTGARQVVY RGGHHKVLLA
HAALTRRSET GIEGDIRLFT EAGEPVAEIL GFKARAIRKL IAAGMGAENV RRFYRPAWVQ
TELLPHFAEP LTALVLGRDG PLLEQFSQVS AGQGIMVDTL KIDDVDQAVL AEALAQTNDA
ILYLCSPTED ATGKQGIAEI LRLVRAIRVS EDGEAAPKCL IVTRGAVSAE ALQSDDLDTG
QAAIRGFARG VASERPDLAL RIVDIGRVVD EATLQQLCAE IVQQDTEDDI VLRPGLRAVG
RLTPSETKPE PVPTLYHPNE TADGRLVGVR LVSASNGSLD RLHHERFVAD PLQPGQVLFR
TLAAALNFKD ILKATGLIPQ SVVDDTFHGE TLGMEASAEV IALGEGVTDF APGERYLVSW
PGCFASHFTA DAESIFALPI EGLGSPLEAA TLPVAFITAY YGLCRLAHLE KGETVLIHSG
TGGVGLAAIQ LAKRVGARIF ATAGSPEKRQ YLKELGCEGV WDSRSLEFAE GIRDVTQGRG
VDVVLNSLPG EGQTHSLSIV APYGRFVEIG KKDIIEKRGL PLAPFNENLS FFSLDLDRMM
LERPALMRSL LSDVAALSKS GDVQPLPLES FPARDAAGAF RLLASAKHMG KVVIDYSDLD
DLKASPLPRP QPQVSDGKTY LVTGGLSGFG WATAEWLIEQ GARNLVLLGR RTPEETGVSE
QLAIQRAAGV HIHTILVDVS HEEAMQDVFE EIAFTSNLPP IRGIFHCAGI LDDALVQNLD
EERIGRVLEA KAQGAIILDR LVQGMDLDYF VLFSSVTTVL GNVGQSAYIA ANAVLGAVAA
NRWKDGEAAL AVDWGAIADV GMLSRNETAA RALEAAGLKG MPAHDALDHL PEMLALELPE
VACVEIDWKK WAQIVPGANV LARFSLVRLA DASNGATSER LATLSALPED ERLPYVVEQV
KVLIAQTLHL EPTSIDDRAR LSELGIDSLA GVELQTALRV EFGVEVSILV LARDESIRKM
SQFLLNRVKI GQTAQLP
//
