ID A0A252BKL6_9PROT Unreviewed; 290 AA.
AC A0A252BKL6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:OUJ06247.1};
GN ORFNames=HK24_10515 {ECO:0000313|EMBL:OUJ06247.1};
OS Gluconobacter sp. DsW_058.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae; Gluconobacter.
OX NCBI_TaxID=1511210 {ECO:0000313|EMBL:OUJ06247.1, ECO:0000313|Proteomes:UP000194786};
RN [1] {ECO:0000313|Proteomes:UP000194786}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Winans N.J., Newell P.D., Douglas A.E.;
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUJ06247.1}.
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DR EMBL; JOPH01000057; OUJ06247.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A252BKL6; -.
DR Proteomes; UP000194786; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000194786}.
FT DOMAIN 5..157
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 161..278
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 167
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 290 AA; 30275 MW; 9DD6A97C54E0A988 CRC64;
MPDMKIGFIG YGAMAQRMGA NLRRAGYSVV AFAPSGGKDE TEMLPSPRAI AEAADVIILC
VPNDAAENQS LEGENGMLAG ISKGKLVLDT STVSPEQALA LAKIAAENGF VVLDAPMSGS
TPEAETGDLV MLVGGDAETV ERAKPILNIV GKLTIHAGPA GSAARLKLVV NGVMGATLNV
IAEGVSYGLK AGIDRDVLFD TLQQVAVVSP HHKRKLKMGQ DKSFPSQFPT RLMSKDMGLL
IDAGRKVGAF MPAMAIADQA LGLSNRQHAD EDYSALIGAM EHSVANTPHK
//
