ID A0A252F0J9_9CLOT Unreviewed; 1248 AA.
AC A0A252F0J9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=CBW42_13510 {ECO:0000313|EMBL:OUM19343.1};
OS Butyricicoccus porcorum.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Butyricicoccus.
OX NCBI_TaxID=1945634 {ECO:0000313|EMBL:OUM19343.1, ECO:0000313|Proteomes:UP000194903};
RN [1] {ECO:0000313|EMBL:OUM19343.1, ECO:0000313|Proteomes:UP000194903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BB10 {ECO:0000313|EMBL:OUM19343.1};
RA Trachsel J., Humphrey S., Allen H.K.;
RT "Butyricicoccus porcorum sp. nov. a butyrate-producing bacterium from the
RT swine intestinal tract.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUM19343.1}.
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DR EMBL; NHOC01000020; OUM19343.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A252F0J9; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000194903; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014152; AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02785; addA_Gpos; 1.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000313|EMBL:OUM19343.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000194903}.
FT DOMAIN 60..529
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 556..835
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 81..88
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1248 AA; 140212 MW; 7441D5944660932A CRC64;
MHARCGAARR RTPVPGVRTA LCAALTQSWA ISHTTSPRSS RRTSGRRLTA NWKERMDMGV
NWTAEQQAAI SNRGGTLLVS AAAGSGKTAV LVERVLQRVT DPDNPCDIDS FLIVTFTKAA
ASEMRGKIAD ALTALAAQHP RDIRLRRQLM LVHRAKITTV HAFCMSLLRE HFHELGLPPD
FRTADESEQA AMQADVLEDV LEAQYAREED GFAALVDILS AGRDDKRLQD IVLETFRNLQ
ASPHPARVLA GYREQFVRPF DRLADTDWGR ELLDTAKGRI QYAIAALENA LDEMQGAEDV
RVKYEPAFQD DVNAARTLLT LVEDGAWNAA VQQCREVRRS RARLGAVRGY EDKAFLDRLK
QARETWKEIS FELMDSVLCM TEEEVRLDMD MMAPAVCALC DTVQAFMDAY QQEKLRRGVV
DFNDLEHFAV ELLTDADGAP TQLANDMHFS EIMVDEYQDT NAVQDAIFRA VSDEEKNIFM
VGDVKQSIYR FRLANPAIFL QKYLAYRDAE DVTDAAPRRV VLSKNFRSRP QVLDSVNFLF
SALMSEQLGD LDYTDREALH VGASFPEGTD DYRTEVCLLE TQTDDEDAPE AIRQEADYCA
GRIREMLEGG FRVTDKQTGE LRPCRPEDFV ILLRSAKNKA PVFQKALSEC GIPAGADAPD
DMLDTPEVHT LVSWLEIVDN PRQDVPLLAA LTSPLAGFTE QELAEIRLAD RDSDFYTAMR
ASAETNEKAR AFLEQLEELR LFAADVPVRQ LLWHIVDSTG AMGIFGAMPG GRARQHHITA
LTELAGSFER GGSRGLFAFV RFLRELRETG GTLTVPDSEE AAGMVRIMTI HKSKGLEFPI
VILANCAKQF NELDLHKPVL LHERMGISMR CRDMARGIQY DGLDRRAMAC ALRREMVSEE
LRVLYVALTR AKEKLICTCA VRDTAKQAEK WAAIASLDPI PPYALAGANQ YALWLCVPLM
RHPNATQLRA LCSQPPELDV YAPDCFAVRL VPYRRQEGVE LAEVHGTFAE SERLEAPVLR
PYAADVLSDL PSKLTATAIT DSFRAQEAQE DTQPPKYSTE LRRPFFDRDA RGLTPSEIGT
AHHLFLQFCD FARCESAEGR AAERERLRER HILSDAQADA IRMDNIAAFF ESDLYRELKG
AQAVHREFKF SVLVPAGDYY PQAVDFPEER VLMQGVIDCL IETKDGLLVL DFKTDRVPKS
RVRERAEQYR AQLSAYRRAA EEVFGRPVQA CALFFLHSGQ TVWLRGTE
//
