ID   A0A252F7Z7_9CLOT        Unreviewed;       442 AA.
AC   A0A252F7Z7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   RecName: Full=Multidrug export protein MepA {ECO:0000256|ARBA:ARBA00022106};
GN   ORFNames=CBW42_01255 {ECO:0000313|EMBL:OUM21876.1};
OS   Butyricicoccus porcorum.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Butyricicoccus.
OX   NCBI_TaxID=1945634 {ECO:0000313|EMBL:OUM21876.1, ECO:0000313|Proteomes:UP000194903};
RN   [1] {ECO:0000313|EMBL:OUM21876.1, ECO:0000313|Proteomes:UP000194903}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BB10 {ECO:0000313|EMBL:OUM21876.1};
RA   Trachsel J., Humphrey S., Allen H.K.;
RT   "Butyricicoccus porcorum sp. nov. a butyrate-producing bacterium from the
RT   swine intestinal tract.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. MepA subfamily. {ECO:0000256|ARBA:ARBA00008417}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUM21876.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NHOC01000001; OUM21876.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A252F7Z7; -.
DR   OrthoDB; 9808954at2; -.
DR   Proteomes; UP000194903; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd13143; MATE_MepA_like; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR045070; MATE_MepA-like.
DR   InterPro; IPR048279; MdtK-like.
DR   PANTHER; PTHR43823:SF3; MULTIDRUG EXPORT PROTEIN MEPA; 1.
DR   PANTHER; PTHR43823; SPORULATION PROTEIN YKVU; 1.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000194903};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        91..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        133..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        161..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        188..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        269..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        314..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        358..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        383..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   442 AA;  47969 MW;  48188CE3E063A303 CRC64;
     MNSFERPITP GFVLRFTLPG MLMMLFNSFY TMVDGGFVSN FVSTDALSAI NIVFPLINFV
     LAVGIMLASG GSAVTARQMG EKEPELARQS FSLLVAFSAG LGIVIAILSI VFVDPIVWAL
     GSTDALYGYC RDYLVFMSLF TPCCMLQILF QFFFTTAGRP HLGLASTLLG GIANMVLDYV
     LIVPLHMGIR GAAIATGIGQ AIPTVIGLVY FFSRHNDLLY FVRPVMRGWV LGRACLNGSS
     EMVSNLAVAV TTYLFNIIML SYLGEDGVAA ITIVLYAQFF FTAIFFGYTS GVAPLISFHF
     GAHNQNRLKQ LVRLSLLFVV VCSLLAYGGS VVLSQTVVGM FAQRGTAVFS IASDGMELFA
     IGFLFMGFNI FASGLFTALS NGMVSAVLSF LRTFVFLIAA IELLPKLCGV SGVWLAIPAA
     ELLALVVALF CILRYRKQYQ YL
//