ID A0A254NAN4_9BURK Unreviewed; 865 AA.
AC A0A254NAN4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=CDO81_09465 {ECO:0000313|EMBL:OWR04790.1};
OS Roseateles puraquae.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Roseateles.
OX NCBI_TaxID=431059 {ECO:0000313|EMBL:OWR04790.1, ECO:0000313|Proteomes:UP000197446};
RN [1] {ECO:0000313|EMBL:OWR04790.1, ECO:0000313|Proteomes:UP000197446}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG 52769 {ECO:0000313|EMBL:OWR04790.1,
RC ECO:0000313|Proteomes:UP000197446};
RX PubMed=17978231; DOI=10.1099/ijs.0.65149-0;
RA Gomila M., Bowien B., Falsen E., Moore E.R., Lalucat J.;
RT "Description of Pelomonas aquatica sp. nov. and Pelomonas puraquae sp.
RT nov., isolated from industrial and haemodialysis water.";
RL Int. J. Syst. Evol. Microbiol. 57:2629-2635(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWR04790.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NISI01000002; OWR04790.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A254NAN4; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000197446; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR025589; Toprim_C_rpt.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR Pfam; PF13342; Toprim_Crpt; 2.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:OWR04790.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000197446};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 3..143
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 865 AA; 95789 MW; 8F0BA25A2DB20684 CRC64;
MSKTLIIAEK PSVAQDIVRA LTPVAGKFDK HDDYFENDTY VVSSAVGHLV EIAAPEEYDV
KRGKWSFANL PVIPPHFDLN PIDKNKGRLN ALSKLIRRKD VTALINACDA GREGELIFRL
IEQYARPAKG PWNKPVKRLW LQSMTPAAIR EGFEKLRTDE QMMPLAEAAR CRSEADWLVG
INGTRAMTAF NSRDGGFFLT TVGRVQTPTL SIVVEREEKI RKHVARDYWE LRANFDAQAG
QYEGKWFDPA WKKNDDAERR ADRLWNAADA EAIAKAVLGQ PASVTEESKP STTSCGALYD
LTTLQREANS RFGFSAKTTL SIAQALYEKH KVLTYPRTDS RFLPEDYLAV AKQTAEMIAG
EDLPGPLQAL AAHARVALNN GYIKPTKKVF DNSKVSDHFA IIPTLQAPKS LTEVEAKLYD
LVVKRFLAVF FPPAEFLVTT RISKIEAAGK THHFQTNGKV LVKPGWLAVY GKDVDDEDAN
LVPVQPGEVV CTESVDVKAL QTKPPARYTE ATLLSAMEGA GKLIDDDELR EAMAEKGLGT
PATRAATIEG LISEKYMLRE GRELIPTAKA FQLMTLLRGL DVEDLTKPEL TGDWEHKLAE
MEKGRLKREQ FMAEIAAMTE KMVAKAKGYD RDTIPGDYAT LKTPCPKCGG IVKENYRRFT
CTGKAGDGVD ACGFSIGKIP GGRSFELHEV EQFLRDKKIG PLEGFRSKAG WPFTAELALV
YDDEIANWKL EFDFGEDAKK AENDGEPVDF SGQASLGACP KCQGHVYEHG ANYVCEHSVG
AHVTCDFKTG KVILTQPIEP AQVTKLLADG KTDLLENFVS NKTRRKFKAF LAYDKKEGKV
IFEFEPRAGK APPAKKAAAK KTAKA
//