ID A0A254Q4F0_9BURK Unreviewed; 498 AA.
AC A0A254Q4F0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN ORFNames=CBI30_09460 {ECO:0000313|EMBL:OWS70372.1};
OS Polynucleobacter aenigmaticus.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Polynucleobacter.
OX NCBI_TaxID=1743164 {ECO:0000313|EMBL:OWS70372.1, ECO:0000313|Proteomes:UP000198104};
RN [1] {ECO:0000313|EMBL:OWS70372.1, ECO:0000313|Proteomes:UP000198104}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MWH-K35W1 {ECO:0000313|EMBL:OWS70372.1,
RC ECO:0000313|Proteomes:UP000198104};
RA Hahn M.W.;
RT "Polynucleobacter sp. MWH-K35W1 isolated from the permanently anoxic
RT monimolimnion of a meromictic lake.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWS70372.1}.
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DR EMBL; NGUO01000015; OWS70372.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A254Q4F0; -.
DR OrthoDB; 9806359at2; -.
DR Proteomes; UP000198104; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd02213; cupin_PMI_typeII_C; 1.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR049577; GMPP_N.
DR InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; TIGR01479; GMP_PMI; 1.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Isomerase {ECO:0000313|EMBL:OWS70372.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:OWS70372.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OWS70372.1}.
FT DOMAIN 6..315
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 343..493
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 498 AA; 54711 MW; 9DA0D73DFB4F627D CRC64;
MTQVTPVILC GGSGTRLWPL SRSGFPKQFL VLSGDDSSQS LFQQAVERIN AISSSHIQVG
STLIVTNEDH RFLALDQLRD LKGIQATLLL EPSGRNTAPA LTLAAFQAKD GVGDQDGGSH
DPILVITPAD QTVKNSKAFT KALQDCIAVV DADHSKKTIA ILGITPAAPE TGYGYIKRSA
IKGTHGEYPV EQFVEKPDSK TAQAYLEDGN YLWNSGMFVL RASTWLAALK EFRPDIFGAT
ETAWVGKTMD RSGQTPFVRP DPEIFKTIPS ESIDYAVIEK CPGSQFRVNM VELNAGWNDL
GAWDAVWQVG KQDEQGNVTS GDILLANSKN SLVHASSRLV SAVGVENLII IETADAVMVA
DRKNSQDVKH IVNQLEAQKR EEKNLHRKVA RPWGWYDSVD EGERFKVKRI QVKPGASLSL
QMHHHRAEHW IVVKGTAEIT NGDQVITLTE NQSTYIPKGQ THRLANPGNT PLEIIEVQSG
SYLGEDDIVR FEDTYGRS
//