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Database: UniProt
Entry: A0A254SLX0_9BACT
LinkDB: A0A254SLX0_9BACT
Original site: A0A254SLX0_9BACT 
ID   A0A254SLX0_9BACT        Unreviewed;       394 AA.
AC   A0A254SLX0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   RecName: Full=Prephenate dehydrogenase {ECO:0000256|ARBA:ARBA00016891};
DE            EC=1.3.1.12 {ECO:0000256|ARBA:ARBA00012068};
GN   ORFNames=B7982_06080 {ECO:0000313|EMBL:OWV23991.1};
OS   Fibrobacter sp. UWB2.
OC   Bacteria; Fibrobacterota; Fibrobacteria; Fibrobacterales; Fibrobacteraceae;
OC   Fibrobacter.
OX   NCBI_TaxID=1964358 {ECO:0000313|EMBL:OWV23991.1, ECO:0000313|Proteomes:UP000197741};
RN   [1] {ECO:0000313|EMBL:OWV23991.1, ECO:0000313|Proteomes:UP000197741}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UWB2 {ECO:0000313|EMBL:OWV23991.1,
RC   ECO:0000313|Proteomes:UP000197741};
RA   Neumann A.P., Suen G.;
RT   "Draft genomes of novel Fibrobacter strains.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 +
CC         NADH; Xref=Rhea:RHEA:13869, ChEBI:CHEBI:16526, ChEBI:CHEBI:29934,
CC         ChEBI:CHEBI:36242, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001162};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC       hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.
CC       {ECO:0000256|ARBA:ARBA00005067}.
CC   -!- SIMILARITY: Belongs to the prephenate/arogenate dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00007964}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OWV23991.1}.
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DR   EMBL; MWQK01000002; OWV23991.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A254SLX0; -.
DR   OrthoDB; 9802008at2; -.
DR   UniPathway; UPA00122; UER00961.
DR   Proteomes; UP000197741; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.30.2130.10; VC0802-like; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR046825; PDH_C.
DR   InterPro; IPR046826; PDH_N.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF13740; ACT_6; 1.
DR   Pfam; PF20463; PDH_C; 1.
DR   Pfam; PF02153; PDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW   Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Tyrosine biosynthesis {ECO:0000256|ARBA:ARBA00022498}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..394
FT                   /note="Prephenate dehydrogenase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5013191374"
FT   DOMAIN          3..300
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51176"
FT   DOMAIN          324..394
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
SQ   SEQUENCE   394 AA;  43471 MW;  AD9F67614D5FDF3B CRC64;
     MVARITMVGF GLLASSIAAA IKQAKLPTKI RAVSSPATLK RARELELADE FFEYGETEKW
     AKDSDLILLC APILHILKMI DALGKVSWAG ANAGREILVS DIGSTKVEIC KAGVRLPAPF
     RFVGSHPMAG SEKRTCEYND PAIFENAYWF VCPPDGTPES VYAPLLEIIR FVGANPVVFP
     PEHHDRTMAW VSHMPQMLSS TLAGNLPERL LKHNYQHFAG RAFRDMTRIA ASGWGMWHDI
     AVTNRDETTR ALCEVRDGLD KTIAAMNGLN VVKDGKPASG DFENDEHSVV ADNSQALADI
     FKAGNDGRAS LFAPGRNNTN SFYEITVQLK DKPGALLSVM QPLAEEGINI RDIELMKVRE
     NVAGTLLLAF KTQEEAARAV KTLQYLEYEV KERR
//
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