ID A0A254TNY1_9BURK Unreviewed; 361 AA.
AC A0A254TNY1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=AYR66_25405 {ECO:0000313|EMBL:OWW22333.1};
OS Noviherbaspirillum denitrificans.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Noviherbaspirillum.
OX NCBI_TaxID=1968433 {ECO:0000313|EMBL:OWW22333.1, ECO:0000313|Proteomes:UP000197535};
RN [1] {ECO:0000313|EMBL:OWW22333.1, ECO:0000313|Proteomes:UP000197535}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSA40 {ECO:0000313|EMBL:OWW22333.1,
RC ECO:0000313|Proteomes:UP000197535};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWW22333.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LSTO01000001; OWW22333.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A254TNY1; -.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000197535; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:OWW22333.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000197535}.
FT DOMAIN 13..346
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 361 AA; 39472 MW; 3ED6E7BA8FDB891B CRC64;
MTEFVHTRIK NNIGFITLDR PKALNSLSLD MVRAITSALL AWRDDSAVQA VVIRSSSERA
FCAGGDIRFF YDAGRATPQG GSALLEDFFT EEYALNHLIH FYPKPYVALM DGIVMGGGMG
VAQGGETNRM RIVTDRTKMA MPEVNIGLFP DVGGGYFLSR VPGEIGTYLG VTGEVIGAAD
ALYAGLADVF VPASELPGLS ELLESADSSR LPQAIREFAA RFQSQVAAGL LAAERATIDR
HFAHDDVTSI VASLSRDDSA FARKTIDTMN KRSPLMMCVT LSQLRKGKTM SVAECLRMER
TMVRRSFENG EVLEGIRSVV IDKDNAPKWS PAQLEDVSKE MVEGFFEPAW PAHAHPLRTL
D
//
