ID A0A255DF07_9MYCO Unreviewed; 767 AA.
AC A0A255DF07;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=isocitrate lyase {ECO:0000256|ARBA:ARBA00012909};
DE EC=4.1.3.1 {ECO:0000256|ARBA:ARBA00012909};
DE AltName: Full=Isocitrase {ECO:0000256|ARBA:ARBA00031022};
DE AltName: Full=Isocitratase {ECO:0000256|ARBA:ARBA00031921};
GN ORFNames=CG716_17135 {ECO:0000313|EMBL:OYN77976.1};
OS Mycolicibacterium sphagni.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1786 {ECO:0000313|EMBL:OYN77976.1, ECO:0000313|Proteomes:UP000216063};
RN [1] {ECO:0000313|EMBL:OYN77976.1, ECO:0000313|Proteomes:UP000216063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33027 {ECO:0000313|EMBL:OYN77976.1,
RC ECO:0000313|Proteomes:UP000216063};
RA Tortoli E., Trovato A., Cirillo D.M.;
RT "The new phylogeny of genus Mycobacterium.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-threo-isocitrate = glyoxylate + succinate;
CC Xref=Rhea:RHEA:13245, ChEBI:CHEBI:15562, ChEBI:CHEBI:30031,
CC ChEBI:CHEBI:36655; EC=4.1.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00023531};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYN77976.1}.
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DR EMBL; NOZR01000014; OYN77976.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A255DF07; -.
DR OrthoDB; 8629576at2; -.
DR Proteomes; UP000216063; Unassembled WGS sequence.
DR GO; GO:0004451; F:isocitrate lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR CDD; cd00377; ICL_PEPM; 1.
DR Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 2.
DR InterPro; IPR039556; ICL/PEPM.
DR InterPro; IPR006254; Isocitrate_lyase.
DR InterPro; IPR018523; Isocitrate_lyase_ph_CS.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR PANTHER; PTHR21631:SF3; BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN; 1.
DR PANTHER; PTHR21631; ISOCITRATE LYASE/MALATE SYNTHASE; 1.
DR Pfam; PF00463; ICL; 2.
DR SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
DR PROSITE; PS00161; ISOCITRATE_LYASE; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:OYN77976.1}.
SQ SEQUENCE 767 AA; 85442 MW; 72F4F22053241F95 CRC64;
MSIIEADATT ESPFEREVAE TQRYIDSPRF EGITRLYTAR QVVEQRGTIP VDHTVAREAA
AAFYKRLREL FSAKKSITTF GPYSPGQAVT MKRMGIEGIY LGGWATSAKG STTEDPGPDL
ASYPLSQVPD EAAGLVRALL TADRNQQYLR LQMTPEQRAA TPAVDYRPFI VADADTGHGG
DPHVRNLIRR FVEAGVPGYH IEDQRPGTKK CGHQGGKVLV PSDEQLKRLN TARFQLDIMN
VPGIIVARTD AEAANLIDSR ADERDQPFLL GATNLKVPPY KSCFLAMVRS FYEAGVTELN
GHLLYALPDG EYAVADAWLR RQGIVDLVAE QAAAWRDGRE RSLDALFDKV ESKFVDAWQD
DAGLDTYADA VAELLKFREG EGETHEMNPA EWLAFANTAS LYAAREKARE LGVDAPWDPE
RAKTPEGYYQ VRGGIPYAIA KSLAAAPFAD ILWMETKTAD LADAREFAEA VHAVYPEKML
AYNLSPSFNW DTTGMSDEEM RAFPEELAKM GFVFNFMTYG GHQIDGVAAE EFATALRQDG
MLALARLQRK MRLVESPYRT PQTLVGGPRS DAALAASSGR TATTKSMGKG STQHQHLVQT
EVPKKLLEEW LALWSEHYQL GEKLRVTLRP RRAGGEVLEL GIWGTRDDGG EEELLANVLV
DPIKDRHGRS ILTVRDQNTF AEKLRQKRLM TLIHLWMVHR FKADAVYYVT PTEDNIYQAD
KMKAHGIFSD VHKDVGEIIV ADVNHDRIAE LLEPDQAALK RLIAKED
//
