ID A0A255DJW3_9MYCO Unreviewed; 439 AA.
AC A0A255DJW3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
GN ORFNames=CG716_12190 {ECO:0000313|EMBL:OYN79688.1};
OS Mycolicibacterium sphagni.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1786 {ECO:0000313|EMBL:OYN79688.1, ECO:0000313|Proteomes:UP000216063};
RN [1] {ECO:0000313|EMBL:OYN79688.1, ECO:0000313|Proteomes:UP000216063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33027 {ECO:0000313|EMBL:OYN79688.1,
RC ECO:0000313|Proteomes:UP000216063};
RA Tortoli E., Trovato A., Cirillo D.M.;
RT "The new phylogeny of genus Mycobacterium.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYN79688.1}.
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DR EMBL; NOZR01000008; OYN79688.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A255DJW3; -.
DR OrthoDB; 108135at2; -.
DR Proteomes; UP000216063; Unassembled WGS sequence.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:InterPro.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 1.10.8.620; ORF12 helical bundle domain-like; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR InterPro; IPR040846; ORF_12_N.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR Pfam; PF18042; ORF_12_N; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Hydrolase {ECO:0000313|EMBL:OYN79688.1}.
FT DOMAIN 36..119
FT /note="ORF 12 gene product N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18042"
FT DOMAIN 165..271
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
SQ SEQUENCE 439 AA; 47562 MW; 0380A54A5F1F3E3E CRC64;
MALATVIASA ATLATSCSPA PTPPANAGAG VRIDLNTPTG VRAKQVMDML NSDWPIGLDN
VKTLATTEMV DPVAHSMDSL WWDRPYTLAG VDIGANVATL HLLTSYGARQ DIDLRIGDDT
FVSRFAVTTE KPKIDSWQDV DTALSRTGAR YSWQVSKVND GRCEKVAGTN TSESLPLASI
FKTYVLYAVE SAITAGTLNW DDKLTITAEG KKLGTSGFDK LPPGSQITVR QAAGKMISTS
DNMATDLLIG RLGTHAIEEA LVAAGHHDPA SMTPFPTMRE LFAIGWGNPD VRQEWKTAAM
PQDRANLLQQ ADSRPYDPDP YRSHAPGSAY GAEWYGNAED ICRVHAGLQH NAVGRASQVK
DVMSETAGID LDPAEWPYIA AKAGNLPGDM TFSWYAVDRT GQAWVVSFQF NWPRFHSANA
GGWAMTIIKQ VFGLLPRYR
//
