ID A0A255G2T3_9ACTN Unreviewed; 1303 AA.
AC A0A255G2T3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Amino acid adenylation protein {ECO:0000313|EMBL:OYO08676.1};
GN ORFNames=CGZ94_19365 {ECO:0000313|EMBL:OYO08676.1};
OS Enemella evansiae.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Enemella.
OX NCBI_TaxID=2016499 {ECO:0000313|EMBL:OYO08676.1, ECO:0000313|Proteomes:UP000215896};
RN [1] {ECO:0000313|EMBL:OYO08676.1, ECO:0000313|Proteomes:UP000215896}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NML 030167 {ECO:0000313|EMBL:OYO08676.1,
RC ECO:0000313|Proteomes:UP000215896};
RA Bernier A.-M., Bernard K., Domingo M.-C.;
RT "Draft whole genome sequences of clinical Proprionibacteriaceae strains.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYO08676.1}.
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DR EMBL; NMVO01000018; OYO08676.1; -; Genomic_DNA.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000215896; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd05930; A_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR012728; NRPS_C.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR NCBIfam; TIGR02353; NRPS_term_dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 3.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000215896};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 611..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 831..859
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 871..894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1075..1099
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1105..1132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 501..575
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1032..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1280..1303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1303 AA; 137781 MW; 9F86A74B5AEED05A CRC64;
MREDEAVVAD PLLRADRAPE PRTLIDIITR TADTHPDEPA LDNGAEVLTY SEFLEAARTV
ADVLHANGVG SGDRVGIRLP SGTTDLYVAI LGAMLAGAAY VPVDFDDPDE RAQLVFGEAE
VTAIIGRDLT VSPTGDSPEP VTGPIEIGIE LDAWVIFTSG STGKPKGVAV PHRCAAAFVD
AERRLFLQAR PIGPGDRVMA GLSVAFDASC EEMWLAWAYG ACLVTAPRSL VKSGVDLGPW
LTKNRITIVS TVPTLVQMWP TEALDRVRLL ILGGEACPPE IGARLATTDR EVWNTYGPTE
ATVVACAARL TGEPPVRIGL PLDGWDLAVV DGEGNPVPDG GDGELIIGGV GLAHYLDPVK
DREKYAPMAS LGWDRAYRSG DLVRRDPRGL LFLGRADDQI KLNGRRIELG EIDSALLTLP
GVEGAAAAIR KSDTGNSLLV GYVTVTDGFD LKASTAALRE AMPAAMVPRL AVVDSLPTRT
SGKIDRDALP WPLPSTGSGQ GVFTETEAWI AELWQSILGT GPDSVSDDFF DLGGGSLTAA
QLVSRLRTRH PEVTVADVYA TPTLGALAAQ LADSDTGPGI RNEDVTPIGR RTQLVQVAAT
IAVRAVAGLR LLIWLGIAAL VVGLVTGGSV AWLPNPPWWV LLIGWLLLIS PWGRMGLAAL
AARALTAGIG PGSYPRGGRT HLRIWAAELV ADELGATNLA NAGWIRTYAR WLGCRIGAQV
DLHSLPPVTG HLRLGRGAAV ESEVDLRGHW IDGNTVHVGK MRVGPGARIG ARSTLLPGAD
VGPGAEVAPG SAIFGVVPAD EAWSGAPATR SGAARGPWSE RPKQNNLWAP AYNIASVAIA
LLPGIAILAG IAVAAPGLVR AGSIGAAAGW AYAWLIPASI VGYLVLMLLI LGVVRLLSLR
LHPGPHPVLG RQAWQAWGII RLLDEARGWL FGLYASTWTP TWLRALGARI GKDVEASTTL
MIPSLVQVGD GSFLADDTLI GGYELGGGWL RVERVKIGKR AFVGNSGMAA PGRKVPKQGL
VAVLSAAPRR TKAKKGSSWL GSPPQKLRRE TGAADESRTY APPARLKRLR ALVELCRIVP
AWVNIALHLA VVFALAAAWQ VSPWLAVLLG APVLVLAGLL AGTVTVAAKW LLVGRIRPSE
YPLWSSMVWR NELADTFTEV LALPWLIRGT SGTPVLTAFL RAMGARIGRG VWCETYWLPE
PDLIRIGAGA TIDPGCVVQT HLFHDRVLSM DTVTLGAGAT LGPNSVILPA AEIGAHATVG
PASLVMRGES IPEQTRWIGN PVGPWLTAQP GVPKDRSRKE PSR
//
