ID A0A255GBD5_9ACTN Unreviewed; 302 AA.
AC A0A255GBD5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:OYO11716.1};
GN Name=mmsB {ECO:0000313|EMBL:OYO11716.1};
GN ORFNames=CGZ94_14995 {ECO:0000313|EMBL:OYO11716.1};
OS Enemella evansiae.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Enemella.
OX NCBI_TaxID=2016499 {ECO:0000313|EMBL:OYO11716.1, ECO:0000313|Proteomes:UP000215896};
RN [1] {ECO:0000313|EMBL:OYO11716.1, ECO:0000313|Proteomes:UP000215896}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NML 030167 {ECO:0000313|EMBL:OYO11716.1,
RC ECO:0000313|Proteomes:UP000215896};
RA Bernier A.-M., Bernard K., Domingo M.-C.;
RT "Draft whole genome sequences of clinical Proprionibacteriaceae strains.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Amino-acid degradation. {ECO:0000256|ARBA:ARBA00005023}.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYO11716.1}.
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DR EMBL; NMVO01000015; OYO11716.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A255GBD5; -.
DR OrthoDB; 3185659at2; -.
DR Proteomes; UP000215896; Unassembled WGS sequence.
DR GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0009083; P:branched-chain amino acid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR011548; HIBADH.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR01692; HIBADH; 1.
DR PANTHER; PTHR22981:SF7; 3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Branched-chain amino acid catabolism {ECO:0000256|ARBA:ARBA00022456};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000215896}.
FT DOMAIN 3..160
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 166..290
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 171
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 302 AA; 30998 MW; 6A923BDD438E5B6B CRC64;
MATIGWIGLG NMGNPMTANL VKAGHEVRGF DLNPEALRTA AANGVTPATS IADAVSGAEV
VFTMLPKGEH ARSAYAGADG VFANAAPGTL LIDSSTIDVE TAGELHQQAA DQGFRFVDAP
VSGGISGAAA GTLAFMIGGK EADVEAAKQF IDPMAGNMIA TGGPTTGQAA KICNNMMLFI
ELQACAEGAV LANKLGLDAQ VFWNIASVSS GNCWALRTWY PVPGVVETAA ANRNFDATFA
TSLAHKDAGL ALAGAKQVGV ELPAAQLAYD QLQKLMDDGY ADKDCSLVIR NIDPQAPGTE
NL
//
