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Database: UniProt
Entry: A0A255GLI8_9ACTN
LinkDB: A0A255GLI8_9ACTN
Original site: A0A255GLI8_9ACTN 
ID   A0A255GLI8_9ACTN        Unreviewed;       308 AA.
AC   A0A255GLI8;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   13-FEB-2019, entry version 6.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=CGZ94_04770 {ECO:0000313|EMBL:OYO16262.1};
OS   Propionibacteriaceae bacterium NML 030167.
OC   Bacteria; Actinobacteria; Propionibacteriales; Propionibacteriaceae.
OX   NCBI_TaxID=2016500 {ECO:0000313|EMBL:OYO16262.1, ECO:0000313|Proteomes:UP000215896};
RN   [1] {ECO:0000313|EMBL:OYO16262.1, ECO:0000313|Proteomes:UP000215896}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NML 030167 {ECO:0000313|EMBL:OYO16262.1,
RC   ECO:0000313|Proteomes:UP000215896};
RA   Bernier A.-M., Bernard K., Domingo M.-C.;
RT   "Draft whole genome sequences of clinical Proprionibacteriaceae
RT   strains.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OYO16262.1}.
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DR   EMBL; NMVO01000004; OYO16262.1; -; Genomic_DNA.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000215896; Unassembled WGS sequence.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000215896};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215896}.
FT   DOMAIN        6    185       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      200    277       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        178    178       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   308 AA;  33009 MW;  780D660C7BE7AADF CRC64;
     MSAEERYGYL GPANTFCHQA LLSIPDAPPD PVPYPSVLLA LEAVRAGEIA AALVPIENSV
     EGGVSATLDD LTYGRPLRIV SEVLLPVQFN LYARPGTKLS EVHRVVSHPH AIAQVRQWLT
     THLPDVQIVT EGSTAAGAVT VADPESGFDA TVCAAVAGEA NRLTALATEI ADNADAVTRF
     VLVTRPGPPP ERTSADKTTV VVFLNDDDSG SLMRMLEQFA SRGVNLSRIE SRPSRLVRGA
     YSFSIDAHGH LADERVAGAL KGIKRTSREV VFLGSYPRAD KVRPAVDRGH TDGDYRAANE
     WLAELTNP
//
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